Enrichment Analysis

This analysis uses the R package: pathfindR: An R Package for Enrichment Analysis Utilizing Active Subnetworks.

citation: Ulgen E, Ozisik O, Sezerman OU. 2019. pathfindR: An R Package for Comprehensive Identification of Enriched Pathways in Omics Data Through Active Subnetworks. Front. Genet. https://doi.org/10.3389/fgene.2019.00858

The aim of PathfindR is to exploit interaction information to extract the most relevant pathways for enrichment analysis. This pathway analysis method identifies genes that are active in sub networks (known to be interconnected) of a given protein-protein interaction network (PIN). It then performs enrichment analysis for each active sub network. The identified pathways are then clustered for functionality to reduce the complexity of the analysis. The overall activity of each pathway is scored and activity per sample can be estimated.

PathfindR integrates information from differential expression/methylation, PIN via active subnetwork identification, and pathway/gene set annotation to identity the of the mechanisms driving a phenotype.

This differs from commonly used over representation analysis and functional class scoring methods, which consider the number of genes identified in a gene list and do not take into account interaction information. They typically also ignore fold changes of p-values.

Analysis Steps (Summarizing the paper and github repo)

Input and format the dataset

  • The input data is
    • gene symbols
      • e.g., Gene_symbol
      • if a gene symbol is not in the chosen protein-protein interaction network (PIN), it is converted to an alias symbol if there is an appropriate alias symbol in the PIN
    • change values (optional)
      • e.g., logFC
    • associated p-values
      • e.g., adjPval

Map the statistical significance of each gene onto a PIN

  • Input genes with associated p-values are mapped on to the PIN.
  • The mapped hits are used to search for active subnetworks.
    • An active subnetwork is a subnetwork in the PIN containing an optimal number of significant nodes that maximizes the overall significance of the subnetwork
    • Active subnetworks have genes/proteins in direct contact or in indirect contact via a non-input node
  • Three algorithms implemented in the pathfindR package for active subnetwork search (see paper for details):
    • Greedy algorithm (default - tends to result in multiple active subnetworks)
    • Simulated annealing algorithm (tends to choose the single highest scoring active subnetwork)
    • Genetic Algorithm (tends to choose the single highest scoring active subnetwork)

Filter the subnetwork

  • The identified active subnetworks are filtered by scores and numbers of significant genes.
    • has a score larger than the given quantile threshold (default is 0.80)
    • contains at least a specified number of input genes (default is 10).

Run the enrichment analyses on active subnetworks

  • Enrichment analysis is run on filtered lists of active subnetworks.
    • Enrichment is performed via one-sided hypergeometric testing
      • enrichment tests use only the genes in the PIN as background genes.
    • significantly enriched terms are identified using the genes the active subnetworks
      • enriched terms = pathways or gene sets
    • Enriched terms are discarded if they have an adjusted p-values (default-Bonferroni method) > a given threshold are discarded
    • The lowest lowest adjusted p-value for a term is kept (across all active subnetworks).
    • Enrichment is run for n iterations in parallel.
      • for each significantly enriched term, the lowest and the highest adjusted p-values, and the number of occurrences across iterations are reported.
  • Pathway clustering
    • Enrichment analysis usually recovers many related pathways.
      • pathways are clustered (describes in the paper)
        • hierarchical clustering (default)
        • fuzzy clustering method
  • Pathway scoring
    • a pathway score matrix is calculated for each sample.
    • Scores can be plotted as a heat map

Avalible PINs:

“Biogrid”, “STRING”, “GeneMania”, “IntAct”, “KEGG” and “mmu_STRING”, custom

###The available gene sets: “KEGG”, “Reactome”, “BioCarta”, “GO-All”, “GO-BP”, “GO-CC”, “GO-MF”, and “mmu_KEGG”, custom

Output columns

Fold Enrichment: Fold enrichment value for the enriched term (Calculated using ONLY the input genes). This is calculated as the proportion of pathway genes within all INPUT (not subnetwork) genes over the proportion pathway genes within the background genes. For example, if the proportion of pathway genes in the input is 0.5 and the proportion of pathway genes in the background is 0.25, the fold enrichment value is 2. The background genes in pathfindR is used as all the genes in the protein-protein interaction network.

occurence: the number of iterations that the given term was found to enriched over all iterations (as the active subnetwork search + enrichment processes are run for multiple (by default 10) iterations)

support: the median support (proportion of active subnetworks leading to enrichment within an iteration) over all iterations. This reflects how many subnetworks support the enrichment

lowest and highest p values: these are the lowest and highest adjusted-p values of enrichment observed over all iterations

Running PathfindR

Load libraries - silent loading

suppressPackageStartupMessages({
  
library(tibble)
library(plyr)
#library(RColorBrewer)
#library(pheatmap)
#library(ggfortify)
#library(DEqMS)
library(readxl)
library(tidyr)
library(dplyr)
#library(ggplot2)
#library(fgsea)
#library(RforProteomics)
#library(ggrepel)
library(pathfindR)

})

Set objects

This chunk is only important if… you have abundance data - and its human

# sample names - should match columns in file
Col_list <- c("m_n_vt2_10","m_n_vt2_14","m_n_vt2_16","m_n_vt2_18","m_n_vt2_23","m_t_vt2_02","m_t_vt2_05","m_t_vt2_06","m_t_vt2_28","m_t_vt2_29R","m_t_vt2_30","m_t_vt2_32","m_t_vt2_37","m_t_vt2_40")

# group identity for samples in Col_list
grp <- c("n","n","n","n","n", "t","t","t","t","t","t","t","t","t" )

# treatment group
cases <- c("m_t_vt2_02","m_t_vt2_05","m_t_vt2_06","m_t_vt2_28","m_t_vt2_29R","m_t_vt2_30","m_t_vt2_32","m_t_vt2_37","m_t_vt2_40")
#path to file
file <- "/Users/eguswa/Documents/R_markdown_with_expalinations/RNAseq/Bullhead_rnaseq/Just_memph/pathfindR/pathfinder_input.xlsx"


#path for output - will make directory in location of R project - or where specified
outdir <- "/Users/eguswa/Documents/R_markdown_with_expalinations/RNAseq/Bullhead_rnaseq/Just_memph/pathfindR/"



# protein interaction network to run on the pathfindR differentially expressed protein dataset using the Protein Interaction Network (pin) of your choice:
# "Biogrid", "STRING", "GeneMania", "IntAct", "KEGG", "mmu_STRING"

pin <- "KEGG"

gene_sets = "KEGG"

# adjustment methods for pathfindF() pathway enrichment - options:
# “holm”, “hochberg”, “hommel”, “bonferroni”, “BH”, “BY”, “fdr”, “none”"
# default is bonferroni
adj_method = "bonferroni"

# enrichment threshold options for  pathfindF() pathway enrichment: 
# adjusted-p value threshold used when filtering enrichment results (default = 0.05)
enrichment_threshold = 0.05

# several more options to play with

# number of terms to show in first enrichment plot - will add more options for later plots
top_terms <- 15

Load files and make dataframes.

The minimum requirement is that there is a column named Gene_Symbol and a column named P.value

#make outdir
dir.create(outdir, recursive = TRUE)
## Warning in dir.create(outdir, recursive = TRUE):
## '/Users/eguswa/Documents/R_markdown_with_expalinations/RNAseq/Bullhead_rnaseq/Just_memph/pathfindR'
## already exists
df.prot <- read_excel(file)

#if have abundance data

dat <- df.prot %>% arrange((P.val)) %>% group_by(Gene_Symbol) %>% slice_head() %>% ungroup() %>%  select(Gene_Symbol, all_of(Col_list))  %>% drop_na() %>% column_to_rownames("Gene_Symbol")


datPF <- df.prot  %>% select(Gene_Symbol, logFC, P.val) %>% arrange(P.val) %>%  group_by(Gene_Symbol) %>% slice_head() %>% drop_na() %>% ungroup()


datPF <- as.data.frame(datPF)

Convert the pathfindR Kegg gene database to a dataframe.

All PIN use Kegg gene database, b/c it is the default. The dataframe is used to add list of all genes in a pathway to the results table.

kegg <- plyr::ldply(pathfindR.data::kegg_genes, data.frame) %>% mutate(num_genes_in_path = 1) %>% dplyr::group_by(.data$.id) %>% dplyr::summarize(X..i.. = paste0(.data$X..i.., collapse = ", "), num_genes_in_path = sum(num_genes_in_path)) 
names(kegg)[1] <- "ID"
names(kegg)[2] <- "all_pathway_genes"

Run pathfindR

calculate percent of differentially expressed genes in a pathway and add to the results table adjustment methods “holm”, “hochberg”, “hommel”, “bonferroni”, “BH”, “BY”, “fdr”, “none””

output_df_pin <- run_pathfindR(datPF, pin_name_path = pin,
  adj_method = adj_method,
  enrichment_threshold = enrichment_threshold,
  iterations = 25, list_active_snw_genes=TRUE)
## ## Testing input
## The input looks OK
## ## Processing input. Converting gene symbols,
##           if necessary (and if human gene symbols provided)
## Number of genes provided in input: 10881
## Number of genes in input after p-value filtering: 10881
## pathfindR cannot handle p values < 1e-13. These were changed to 1e-13
## 
## Could not find any interactions for 9746 (89.57%) genes in the PIN
## Final number of genes in input: 1135
## ## Performing Active Subnetwork Search and Enrichment
## ## Processing the enrichment results over all iterations
## ## Annotating involved genes and visualizing enriched terms
## Plotting the enrichment bubble chart
## Found 168 enriched terms
## You may run:
## - cluster_enriched_terms() for clustering enriched terms
## - visualize_terms() for visualizing enriched term diagrams

output_df_pin <- left_join(output_df_pin, kegg)
## Joining with `by = join_by(ID)`
output_df_pin <- output_df_pin %>%
   mutate(num_up_reg_genes_in_path = 1+lengths(regmatches(Up_regulated, gregexpr(",",Up_regulated ))))  %>%
   mutate(num_down_reg_genes_in_path = 1+lengths(regmatches(Down_regulated, gregexpr(",",Down_regulated ))))  %>%
   mutate(percent_up_or_down_genes_pathway = ((num_up_reg_genes_in_path + num_down_reg_genes_in_path) / num_genes_in_path))

Visualize differentially expressed genes in Enriched pathways.

KEGG gives nice figures - might not reflect interactions as well as the others, other pins give networks of stuff - might be more concise

if (pin == "KEGG"){
  
  print(paste0("Visualizing ", pin))
  
  processed_df <- input_processing(
  input = datPF,
  pin_name_path = pin
  )

  visualize_terms(
  result_df=output_df_pin,
  input_processed=processed_df,
  hsa_KEGG = FALSE #TRUE if human
  )
  
  
  } else {
  
  print(paste0("Visualizing ", pin))
  
  visualize_terms(
  result_df=output_df_pin,
  input_processed=processed_df,
  hsa_KEGG=FALSE,
  pin_name_path=pin
  )
  
  }

  old_folder_name <- "term_visualizations" 
  new_folder_name <- paste0(outdir,"/", pin,"_term_visualizations")
  file.rename(old_folder_name, new_folder_name) 

Generate enrichment chart using the top_terms specified by user.

#

pdf(file = paste0(outdir,"/Enrichment_with_", pin, "_top_", top_terms, "_terms.pdf"))


enrichment_chart(
  result_df = output_df_pin,
  top_terms = top_terms
)
## Plotting the enrichment bubble chart
dev.off()
## quartz_off_screen 
##                 2
enrichment_chart(
  result_df = output_df_pin,
  top_terms = top_terms
)
## Plotting the enrichment bubble chart

Cluster enriched terms using defult method.

pdf(file=(paste0(outdir,"/Enrichment_cluster_", pin,".pdf")))

cluster_enriched_terms(output_df_pin, plot_dend = TRUE, plot_clusters_graph = TRUE)
## The maximum average silhouette width was 0.14 for k = 60
##           ID                                           Term_Description
## 1   hsa05012                                          Parkinson disease
## 2   hsa05020                                              Prion disease
## 8   hsa04932                          Non-alcoholic fatty liver disease
## 9   hsa04723                       Retrograde endocannabinoid signaling
## 12  hsa04714                                              Thermogenesis
## 14  hsa00190                                  Oxidative phosphorylation
## 18  hsa05415                                    Diabetic cardiomyopathy
## 21  hsa05208          Chemical carcinogenesis - reactive oxygen species
## 3   hsa04068                                     FoxO signaling pathway
## 4   hsa03050                                                 Proteasome
## 15  hsa05017                                     Spinocerebellar ataxia
## 5   hsa04110                                                 Cell cycle
## 7   hsa04114                                             Oocyte meiosis
## 11  hsa04914                    Progesterone-mediated oocyte maturation
## 24  hsa04120                             Ubiquitin mediated proteolysis
## 6   hsa04115                                      p53 signaling pathway
## 10  hsa00562                              Inositol phosphate metabolism
## 13  hsa04070                      Phosphatidylinositol signaling system
## 16  hsa00230                                          Purine metabolism
## 23  hsa00240                                      Pyrimidine metabolism
## 17  hsa04630                                 JAK-STAT signaling pathway
## 19  hsa04014                                      Ras signaling pathway
## 39  hsa04010                                     MAPK signaling pathway
## 58  hsa04015                                     Rap1 signaling pathway
## 20  hsa04211                               Longevity regulating pathway
## 25  hsa04931                                         Insulin resistance
## 27  hsa04152                                     AMPK signaling pathway
## 29  hsa04922                                 Glucagon signaling pathway
## 46  hsa04910                                  Insulin signaling pathway
## 47  hsa04213            Longevity regulating pathway - multiple species
## 61  hsa04936                                    Alcoholic liver disease
## 71  hsa04920                            Adipocytokine signaling pathway
## 22  hsa05166                    Human T-cell leukemia virus 1 infection
## 65  hsa05203                                       Viral carcinogenesis
## 26  hsa03320                                     PPAR signaling pathway
## 147 hsa00071                                     Fatty acid degradation
## 28  hsa05132                                       Salmonella infection
## 49  hsa05131                                                Shigellosis
## 57  hsa05135                                         Yersinia infection
## 74  hsa05130                      Pathogenic Escherichia coli infection
## 30  hsa04668                                      TNF signaling pathway
## 31  hsa05170                   Human immunodeficiency virus 1 infection
## 37  hsa05163                            Human cytomegalovirus infection
## 45  hsa04380                                 Osteoclast differentiation
## 52  hsa05417                                  Lipid and atherosclerosis
## 73  hsa05167            Kaposi sarcoma-associated herpesvirus infection
## 85  hsa04210                                                  Apoptosis
## 32  hsa04064                               NF-kappa B signaling pathway
## 33  hsa04728                                       Dopaminergic synapse
## 55  hsa04926                                  Relaxin signaling pathway
## 56  hsa04918                                  Thyroid hormone synthesis
## 60  hsa04261                     Adrenergic signaling in cardiomyocytes
## 64  hsa04935             Growth hormone synthesis, secretion and action
## 68  hsa04911                                          Insulin secretion
## 76  hsa04725                                        Cholinergic synapse
## 82  hsa04925                        Aldosterone synthesis and secretion
## 95  hsa04928        Parathyroid hormone synthesis, secretion and action
## 101 hsa04915                                 Estrogen signaling pathway
## 111 hsa04927                           Cortisol synthesis and secretion
## 121 hsa04929                                             GnRH secretion
## 133 hsa04022                                 cGMP-PKG signaling pathway
## 34  hsa05160                                                Hepatitis C
## 40  hsa05161                                                Hepatitis B
## 42  hsa05162                                                    Measles
## 43  hsa05169                               Epstein-Barr virus infection
## 53  hsa05222                                     Small cell lung cancer
## 135 hsa05164                                                Influenza A
## 35  hsa05142                                             Chagas disease
## 50  hsa05145                                              Toxoplasmosis
## 70  hsa04620                       Toll-like receptor signaling pathway
## 83  hsa05152                                               Tuberculosis
## 86  hsa05171                             Coronavirus disease - COVID-19
## 99  hsa05140                                              Leishmaniasis
## 112 hsa05133                                                  Pertussis
## 130 hsa04625                   C-type lectin receptor signaling pathway
## 36  hsa04919                          Thyroid hormone signaling pathway
## 160 hsa04613                    Neutrophil extracellular trap formation
## 38  hsa04722                             Neurotrophin signaling pathway
## 63  hsa04912                                     GnRH signaling pathway
## 98  hsa04750           Inflammatory mediator regulation of TRP channels
## 41  hsa04622                      RIG-I-like receptor signaling pathway
## 48  hsa04621                        NOD-like receptor signaling pathway
## 54  hsa04657                                    IL-17 signaling pathway
## 44  hsa00760                     Nicotinate and nicotinamide metabolism
## 51  hsa04071                             Sphingolipid signaling pathway
## 59  hsa04371                                   Apelin signaling pathway
## 127 hsa04921                                 Oxytocin signaling pathway
## 62  hsa05215                                            Prostate cancer
## 75  hsa04664                            Fc epsilon RI signaling pathway
## 79  hsa05212                                          Pancreatic cancer
## 81  hsa04917                                Prolactin signaling pathway
## 89  hsa05223                                 Non-small cell lung cancer
## 100 hsa04012                                     ErbB signaling pathway
## 102 hsa04370                                     VEGF signaling pathway
## 106 hsa05221                                     Acute myeloid leukemia
## 108 hsa05218                                                   Melanoma
## 113 hsa05220                                   Chronic myeloid leukemia
## 115 hsa05214                                                     Glioma
## 119 hsa05210                                          Colorectal cancer
## 128 hsa05231                               Choline metabolism in cancer
## 131 hsa05213                                         Endometrial cancer
## 134 hsa04662                          B cell receptor signaling pathway
## 140 hsa05211                                       Renal cell carcinoma
## 146 hsa04666                           Fc gamma R-mediated phagocytosis
## 166 hsa04650                  Natural killer cell mediated cytotoxicity
## 66  hsa04062                                Chemokine signaling pathway
## 67  hsa04933       AGE-RAGE signaling pathway in diabetic complications
## 69  hsa04810                           Regulation of actin cytoskeleton
## 155 hsa04510                                             Focal adhesion
## 72  hsa05205                                    Proteoglycans in cancer
## 91  hsa04916                                              Melanogenesis
## 107 hsa04550   Signaling pathways regulating pluripotency of stem cells
## 109 hsa05224                                              Breast cancer
## 110 hsa05226                                             Gastric cancer
## 120 hsa04934                                           Cushing syndrome
## 150 hsa04150                                     mTOR signaling pathway
## 154 hsa05225                                   Hepatocellular carcinoma
## 77  hsa04140                                         Autophagy - animal
## 78  hsa05207              Chemical carcinogenesis - receptor activation
## 80  hsa05230                        Central carbon metabolism in cancer
## 142 hsa04066                                    HIF-1 signaling pathway
## 163 hsa04973                      Carbohydrate digestion and absorption
## 84  hsa04137                                         Mitophagy - animal
## 87  hsa04218                                        Cellular senescence
## 88  hsa05235     PD-L1 expression and PD-1 checkpoint pathway in cancer
## 96  hsa04658                           Th1 and Th2 cell differentiation
## 103 hsa04660                          T cell receptor signaling pathway
## 132 hsa04659                                  Th17 cell differentiation
## 90  hsa04611                                        Platelet activation
## 92  hsa05030                                          Cocaine addiction
## 116 hsa05031                                      Amphetamine addiction
## 145 hsa05034                                                 Alcoholism
## 93  hsa04924                                            Renin secretion
## 97  hsa04713                                      Circadian entrainment
## 122 hsa04724                                      Glutamatergic synapse
## 124 hsa04720                                     Long-term potentiation
## 129 hsa04970                                         Salivary secretion
## 139 hsa04540                                               Gap junction
## 141 hsa04730                                       Long-term depression
## 149 hsa04726                                       Serotonergic synapse
## 151 hsa04971                                     Gastric acid secretion
## 157 hsa04270                         Vascular smooth muscle contraction
## 94  hsa04020                                  Calcium signaling pathway
## 104 hsa05418                     Fluid shear stress and atherosclerosis
## 105 hsa05219                                             Bladder cancer
## 159 hsa05216                                             Thyroid cancer
## 114 hsa04217                                                Necroptosis
## 117 hsa04215                               Apoptosis - multiple species
## 118 hsa04072                          Phospholipase D signaling pathway
## 123 hsa04530                                             Tight junction
## 125 hsa04350                                 TGF-beta signaling pathway
## 126 hsa04144                                                Endocytosis
## 136 hsa04260                                 Cardiac muscle contraction
## 137 hsa04360                                              Axon guidance
## 138 hsa05321                                 Inflammatory bowel disease
## 143 hsa04710                                           Circadian rhythm
## 156 hsa05410                                Hypertrophic cardiomyopathy
## 144 hsa05120 Epithelial cell signaling in Helicobacter pylori infection
## 152 hsa05110                                  Vibrio cholerae infection
## 148 hsa04310                                      Wnt signaling pathway
## 162 hsa04390                                    Hippo signaling pathway
## 153 hsa04024                                     cAMP signaling pathway
## 158 hsa04670                       Leukocyte transendothelial migration
## 161 hsa04923                      Regulation of lipolysis in adipocytes
## 164 hsa03010                                                   Ribosome
## 165 hsa04742                                         Taste transduction
## 167 hsa04640                                 Hematopoietic cell lineage
## 168 hsa05202                    Transcriptional misregulation in cancer
##     Fold_Enrichment occurrence    support     lowest_p    highest_p
## 1         1.8292876         25 0.12500000 1.130801e-55 2.597446e-26
## 2         1.6665847         25 0.23529412 5.761775e-48 4.500346e-27
## 8         1.8241527         25 0.35000000 1.337914e-25 7.455760e-20
## 9         1.2553495         25 0.17647059 1.286070e-24 1.223207e-20
## 12        1.6809404         25 0.15000000 4.176881e-24 8.291980e-18
## 14        1.8300966         25 0.11764706 2.844520e-23 7.028650e-11
## 18        1.3736390         25 0.11764706 1.471073e-19 4.726090e-13
## 21        1.4366965         25 0.18750000 8.861795e-19 2.653957e-12
## 3         1.5463775         25 0.25000000 4.487469e-40 1.171682e-08
## 4         3.0068451         25 0.05882353 1.226020e-33 2.979845e-28
## 15        1.5229475         25 0.06250000 6.013291e-22 4.943673e-18
## 5         2.3743592          1 0.05882353 2.364733e-31 2.364733e-31
## 7         1.3960352          4 0.05882353 1.946968e-26 4.755571e-02
## 11        1.5954688         21 0.06666667 3.846064e-24 3.941275e-04
## 24        1.8378185          1 0.05882353 4.385403e-17 4.385403e-17
## 6         1.8613803         25 0.06250000 1.360411e-27 1.979353e-23
## 10        1.7593869         25 0.11764706 1.633710e-24 5.021936e-19
## 13        1.2665062         25 0.11764706 5.318512e-24 3.863940e-19
## 16        1.0985195         25 0.05882353 8.085171e-22 7.283707e-17
## 23        1.4441744         25 0.05882353 4.279645e-17 3.045741e-10
## 17        0.9082639         25 0.05882353 1.120779e-19 4.485681e-14
## 19        1.0977371         25 0.26666667 1.553767e-19 5.812880e-06
## 39        0.9306902         25 0.41176471 6.369094e-11 3.068439e-08
## 58        0.9885800         25 0.25000000 2.433538e-09 1.034220e-05
## 20        1.3803495         25 0.31250000 2.260584e-19 4.734851e-16
## 25        1.2231928         25 0.25000000 2.531488e-16 3.063640e-13
## 27        1.5690975         25 0.27777778 2.024612e-15 1.781473e-12
## 29        1.3170144         25 0.31578947 1.760017e-13 4.305054e-11
## 46        1.3043249         25 0.18750000 3.466049e-10 1.984007e-08
## 47        1.0069762         25 0.16666667 4.921795e-10 3.654994e-07
## 61        1.3370478         25 0.35294118 5.751423e-09 8.264046e-07
## 71        1.3758028         25 0.23529412 3.803411e-08 1.303700e-04
## 22        1.4820469         25 0.33333333 3.521550e-18 1.411522e-06
## 65        1.1106579         25 0.20000000 1.268391e-08 1.343007e-03
## 26        0.8902254         24 0.05882353 7.774767e-16 1.373159e-13
## 147       1.4981842         22 0.05882353 4.566128e-03 6.364385e-03
## 28        1.4252410         25 0.18750000 1.396258e-13 1.607805e-05
## 49        1.1576878         25 0.26315789 5.626264e-10 4.152155e-07
## 57        1.4781550         25 0.31250000 2.304547e-09 3.360939e-05
## 74        1.0470264         25 0.12500000 2.188487e-07 2.600788e-02
## 30        1.5595349         25 0.47368421 2.510787e-13 1.254879e-10
## 31        1.1966016         25 0.41176471 6.246538e-13 8.924990e-07
## 37        0.9765986         25 0.52941176 3.560833e-11 1.990330e-07
## 45        1.1079645         25 0.31578947 2.661099e-10 4.978435e-06
## 52        1.0272712         25 0.35294118 1.033419e-09 4.432584e-07
## 73        0.9647992         25 0.45000000 2.078783e-07 4.066796e-04
## 85        1.2268188         25 0.21052632 2.401625e-06 9.892376e-04
## 32        1.3960352         25 0.15000000 1.577634e-12 1.816241e-08
## 33        0.9377947         25 0.41176471 1.914453e-12 3.581821e-10
## 55        0.8224704         25 0.40000000 1.990749e-09 3.307867e-07
## 56        1.0675564         25 0.17647059 2.007248e-09 9.442942e-08
## 60        0.7870266         25 0.23529412 3.994682e-09 7.993436e-07
## 64        0.9772247         25 0.40000000 1.250515e-08 3.695029e-07
## 68        0.7883493         25 0.16666667 2.296463e-08 1.793329e-05
## 76        0.8272801         25 0.31250000 1.005231e-06 3.955496e-04
## 82        0.6465847         25 0.22222222 1.438358e-06 3.898911e-05
## 95        0.8590986         25 0.26315789 8.375171e-06 1.966384e-04
## 101       0.6618241         25 0.31250000 1.701086e-05 3.319780e-03
## 111       0.9907347         25 0.17647059 6.827192e-05 1.797891e-04
## 121       1.0069762         24 0.10263158 2.111184e-04 4.822899e-02
## 133       0.8409851         25 0.23529412 7.542031e-04 1.375335e-02
## 34        1.1603410         25 0.23529412 2.898629e-12 2.154751e-09
## 40        1.2913326         25 0.41176471 6.529909e-11 9.323482e-08
## 42        1.3043249         25 0.33333333 1.244494e-10 4.724475e-08
## 43        1.4311115         25 0.40000000 2.334021e-10 2.252560e-07
## 53        1.6752423         25 0.22222222 1.491552e-09 1.919109e-07
## 135       0.9489390         25 0.11764706 7.715880e-04 1.363069e-02
## 35        1.1057705         25 0.36842105 1.158728e-11 1.568350e-07
## 50        1.0061515         25 0.29411765 5.688601e-10 1.273192e-06
## 70        1.0401831         25 0.29411765 3.656631e-08 1.967112e-05
## 83        0.8566580         25 0.17647059 1.770374e-06 9.244502e-04
## 86        1.0224483         25 0.25000000 3.312677e-06 2.302805e-04
## 99        0.7546136         25 0.17647059 1.343760e-05 3.486242e-04
## 112       0.9055364         25 0.18750000 7.357469e-05 9.331531e-03
## 130       1.0738733         25 0.35294118 4.621091e-04 3.468165e-03
## 36        1.1168282         24 0.05882353 2.771517e-11 2.121381e-09
## 160       0.6940740          5 0.05882353 1.972297e-02 3.795391e-02
## 38        0.9937878         25 0.41176471 3.705729e-11 1.092164e-04
## 63        0.8406234         25 0.21052632 7.268666e-09 3.909257e-06
## 98        0.9711550         25 0.25000000 9.836259e-06 1.060639e-04
## 41        1.3758028         25 0.23529412 9.422708e-11 1.971503e-07
## 48        0.9651602         25 0.22222222 5.336650e-10 3.265924e-07
## 54        1.3353381         25 0.22222222 1.869154e-09 2.042866e-06
## 44        1.1168282         25 0.05882353 2.366418e-10 8.281689e-10
## 51        1.5485433         25 0.35294118 8.113162e-10 2.646628e-07
## 59        1.0116197         25 0.35294118 3.275017e-09 2.477557e-06
## 127       0.6569578         25 0.17647059 3.536775e-04 1.695507e-03
## 62        1.0808015         25 0.22222222 5.989213e-09 1.414845e-05
## 75        1.1845148         24 0.13750000 9.034852e-07 3.602977e-02
## 79        1.3225597         25 0.31250000 1.138140e-06 8.640217e-05
## 81        1.1966016         25 0.41176471 1.377611e-06 1.305015e-03
## 89        0.9572813         25 0.12500000 4.550874e-06 4.535192e-02
## 100       0.9971680         25 0.15000000 1.650468e-05 7.287659e-03
## 102       1.1357575         18 0.10526316 1.856566e-05 3.171483e-02
## 106       1.1668354         25 0.17647059 3.266202e-05 7.364733e-04
## 108       0.9306902         25 0.11764706 5.414650e-05 3.420203e-03
## 113       1.1021331         25 0.25000000 7.898224e-05 2.993283e-03
## 115       0.8934626         24 0.10263158 7.977649e-05 3.023976e-02
## 119       0.8073457         22 0.08333333 1.466323e-04 3.817356e-02
## 128       0.7977344         11 0.05555556 3.941275e-04 8.406676e-03
## 131       0.6739480         24 0.06666667 6.272380e-04 3.435759e-02
## 134       1.0738733         19 0.05882353 7.612100e-04 4.626387e-02
## 140       0.7501085         20 0.06250000 1.292464e-03 4.480615e-02
## 146       1.0470264          2 0.05882353 2.036799e-03 1.252730e-02
## 166       0.6107654          3 0.05263158 3.036627e-02 3.734760e-02
## 66        0.9992673         22 0.10000000 1.274669e-08 2.928906e-02
## 67        1.2285110         25 0.50000000 1.415977e-08 6.974854e-06
## 69        0.9796739         24 0.12500000 3.332444e-08 3.470163e-02
## 155       0.8376211         15 0.05882353 9.639126e-03 2.784437e-02
## 72        0.9806296         25 0.15000000 1.949856e-07 6.751522e-05
## 91        0.7740393         25 0.11764706 7.549080e-06 3.090807e-04
## 107       1.1830807         25 0.13333333 4.314888e-05 7.202468e-04
## 109       1.2155953         25 0.15789474 6.156305e-05 3.117129e-03
## 110       0.9876712         18 0.06066176 6.156305e-05 4.097376e-02
## 120       1.2073818         25 0.31578947 1.498384e-04 3.259538e-03
## 150       1.3329885         21 0.06666667 5.681658e-03 4.637371e-02
## 154       1.2037669         12 0.06250000 8.782227e-03 4.098889e-02
## 77        1.6353556         25 0.31250000 1.012823e-06 1.621949e-05
## 78        0.9533899         25 0.17647059 1.065990e-06 7.674247e-05
## 80        0.9711550         21 0.06250000 1.242789e-06 4.287423e-02
## 142       0.8709211         25 0.06250000 1.556261e-03 2.564212e-02
## 163       1.0152984          7 0.05555556 2.520486e-02 3.169241e-02
## 84        1.8347892          6 0.05263158 1.896690e-06 3.443134e-06
## 87        1.3690152         25 0.29411765 3.351024e-06 1.947287e-03
## 88        1.1293768         25 0.25000000 3.880494e-06 4.729457e-04
## 96        1.1045554         25 0.11764706 8.849872e-06 2.696910e-03
## 103       1.1927291         25 0.29411765 2.105540e-05 5.288261e-04
## 132       0.7828235         25 0.11111111 6.618637e-04 2.819041e-02
## 90        1.2711866         25 0.11764706 5.516379e-06 1.275341e-02
## 92        0.7977344         25 0.23529412 7.724285e-06 3.318136e-04
## 116       0.6474366         25 0.17647059 8.104571e-05 4.008433e-03
## 145       0.6551227         25 0.10526316 1.898447e-03 2.816594e-02
## 93        1.0999066         25 0.05882353 8.229217e-06 4.057520e-04
## 97        0.6332531         25 0.12500000 9.211802e-06 3.904460e-03
## 122       0.3948383         23 0.06666667 2.184690e-04 4.411531e-02
## 124       0.7501085         25 0.13333333 2.540634e-04 6.035296e-03
## 129       0.6884557         25 0.05882353 4.242714e-04 1.370363e-02
## 139       0.7614738         24 0.05882353 1.280787e-03 3.368011e-02
## 141       0.6739480         25 0.11764706 1.410352e-03 3.288938e-03
## 149       0.6443240         21 0.10000000 4.896791e-03 4.786507e-02
## 151       0.4927183         20 0.05882353 6.169115e-03 1.117203e-02
## 157       0.5834177         18 0.05882353 1.730845e-02 2.889468e-02
## 94        0.8609909         25 0.11764706 8.339534e-06 8.110897e-04
## 104       1.2453840         25 0.37500000 2.939269e-05 3.090506e-04
## 105       0.9772247         25 0.05882353 3.185702e-05 4.400582e-02
## 159       0.7546136          9 0.05882353 1.971132e-02 4.983832e-02
## 114       0.9189093         25 0.05882353 7.956339e-05 1.249709e-03
## 117       1.4891043         25 0.06250000 8.174833e-05 7.566453e-03
## 118       0.7217597         19 0.06250000 8.231501e-05 3.460479e-02
## 123       1.0636459         25 0.16666667 2.298507e-04 2.422987e-03
## 125       1.2139437         24 0.05882353 2.953783e-04 7.422386e-03
## 126       0.9948757         22 0.05882353 3.004276e-04 1.096662e-02
## 136       0.7583401         17 0.05555556 7.862696e-04 1.689134e-02
## 137       0.8765803         18 0.05882353 9.554870e-04 2.111165e-02
## 138       0.6980176         17 0.05882353 1.028094e-03 4.363570e-02
## 143       1.8613803         25 0.21052632 1.574741e-03 3.575034e-03
## 156       0.7400669         12 0.05882353 1.040339e-02 2.284557e-02
## 144       0.8775079         24 0.10263158 1.607557e-03 4.535192e-02
## 152       0.6493187          5 0.05882353 6.558405e-03 1.386227e-02
## 148       1.1034530         20 0.05882353 4.698828e-03 1.066262e-02
## 162       1.0670333          8 0.05882353 2.384586e-02 4.976264e-02
## 153       0.6001647         16 0.05882353 8.041354e-03 4.682689e-02
## 158       0.5878043          6 0.05882353 1.745498e-02 4.539073e-02
## 161       0.8665046          1 0.05555556 2.166577e-02 2.166577e-02
## 164       2.7920705          6 0.05263158 2.791943e-02 3.265196e-02
## 165       0.7977344         20 0.05882353 3.027273e-02 4.847475e-02
## 167       0.9627829          1 0.05882353 3.663914e-02 3.663914e-02
## 168       0.8334539          3 0.06666667 3.955734e-02 4.638489e-02
##     non_Signif_Snw_Genes
## 1                   SOD1
## 2                   SOD1
## 8                       
## 9                 PRKACG
## 12                PRKACG
## 14                      
## 18                      
## 21                      
## 3                       
## 4                       
## 15                      
## 5                 ANAPC5
## 7                  MAPK1
## 11                  KRAS
## 24                ANAPC5
## 6                   TP53
## 10                 PLCB3
## 13                 PLCB3
## 16                 ENPP1
## 23                 ENPP1
## 17                 STAT1
## 19                  KRAS
## 39                  KRAS
## 58                  KRAS
## 20                  ATF2
## 25                      
## 27                      
## 29                PRKACG
## 46                      
## 47                      
## 61                      
## 71                      
## 22                   FOS
## 65                      
## 26                  RXRA
## 147                     
## 28                  RAC1
## 49                      
## 57                  RAC1
## 74                  RAC1
## 30                      
## 31                  RAC1
## 37                  ATF2
## 45                  RAC1
## 52                      
## 73                  KRAS
## 85                      
## 32                      
## 33                 PRKCB
## 55                      
## 56                 PRKCB
## 60                  ATF2
## 64                 PRKCB
## 68                 PRKCB
## 76                 PRKCB
## 82                 PRKCB
## 95                 PRKCB
## 101                 ATF2
## 111                     
## 121                 KRAS
## 133                PLCB3
## 34                 STAT1
## 40                  ATF2
## 42                   FOS
## 43                      
## 53                      
## 135                STAT1
## 35                      
## 50                      
## 70                  RAC1
## 83                      
## 86                   FOS
## 99                   FOS
## 112                  FOS
## 130                 KRAS
## 36                  RXRA
## 160                 RAC1
## 38                  KRAS
## 63                  KRAS
## 98                 PRKCB
## 41                      
## 48                      
## 54                      
## 44                 ENPP1
## 51                      
## 59                PRKACG
## 127               PRKACG
## 62                      
## 75                  KRAS
## 79                      
## 81                   FOS
## 89                 MAPK1
## 100                 KRAS
## 102                 KRAS
## 106                MAPK1
## 108                MAPK1
## 113                     
## 115                 KRAS
## 119                 KRAS
## 128                 KRAS
## 131                 KRAS
## 134                MAPK1
## 140                 KRAS
## 146                MAPK1
## 166                 KRAS
## 66                  KRAS
## 67                      
## 69                  RAC1
## 155                     
## 72                 MAPK1
## 91                 PLCB3
## 107                 KRAS
## 109                     
## 110                 EGFR
## 120                PLCB3
## 150                     
## 154                     
## 77                      
## 78                  ATF2
## 80                  KRAS
## 142                     
## 163                PLCB3
## 84                      
## 87                      
## 88                   FOS
## 96                   FOS
## 103                MAPK1
## 132                  FOS
## 90                 PLCB3
## 92                  ATF2
## 116                  FOS
## 145               PRKACG
## 93                 PLCB3
## 97                 PLCB3
## 122                PLCB3
## 124                PLCB3
## 129                PLCB3
## 139                PLCB3
## 141                PRKCB
## 149                 KRAS
## 151                PLCB3
## 157                     
## 94                 PLCB3
## 104                     
## 105                MAPK1
## 159                MAPK1
## 114                STAT1
## 117                     
## 118                PLCB3
## 123                     
## 125                MAPK1
## 126                 EGFR
## 136                     
## 137                 RAC1
## 138                     
## 143                     
## 156                     
## 144                 RAC1
## 152                     
## 148                PLCB3
## 162                     
## 153               PRKACG
## 158                 RAC1
## 161                GNAI3
## 164                     
## 165                PLCB3
## 167                     
## 168                     
##                                                                                                                                                                                                                                                                                                                                                                                     Up_regulated
## 1   ADORA2A, PSMA5, PSMA1, PSMA3, PSMB6, PSMB3, PSMB5, PSMB1, PSMB4, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD3, PSMD9, PSMD11, PSMD6, PSMD7, HSPA5, DDIT3, EIF2S1, SLC18A1, NDUFV1, NDUFA2, NDUFA5, NDUFA9, NDUFA12, NDUFB4, NDUFB5, NDUFB9, NDUFS3, NDUFS4, NDUFS6, NDUFS8, UQCRC1, UQCR10, COX6A1, COX6C, COX8A, ATP5PD, LRRK2, HTRA2, PARK7, BCL2L1, KLC2, TUBB3, TUBB4A, DUSP1, NFE2L2, MAPK9
## 2               STIP1, HSPA5, EIF2S1, DDIT3, PPP3CB, NDUFV1, NDUFA2, NDUFA5, NDUFA9, NDUFA12, NDUFB4, NDUFB5, NDUFB9, NDUFS3, NDUFS4, NDUFS6, NDUFS8, UQCRC1, UQCR10, COX6A1, COX6C, COX8A, ATP5PD, PSMA5, PSMA1, PSMA3, PSMB6, PSMB3, PSMB5, PSMB1, PSMB4, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD3, PSMD9, PSMD11, PSMD6, PSMD7, CAV1, PIK3CB, MAPK9, CREB5, EGR1, CSNK2B, KLC2, TUBB3, TUBB4A
## 8                                                                                                                                                       SOCS3, PIK3CB, GSK3A, ADIPOR1, PRKAA1, PRKAA2, PRKAG1, PRKAG3, MAPK9, TRAF2, EIF2S1, DDIT3, CASP7, NDUFV1, NDUFA2, NDUFA5, NDUFA9, NDUFA12, NDUFB4, NDUFB5, NDUFB9, NDUFS3, NDUFS4, NDUFS6, NDUFS8, UQCRC1, UQCR10, COX6A1, COX6C, COX8A
## 9                                                                                                                                                                                                                                                                                  KCNJ5, MAPK9, NDUFV1, NDUFA2, NDUFA5, NDUFA9, NDUFA12, NDUFB4, NDUFB5, NDUFB9, NDUFS3, NDUFS4, NDUFS6, NDUFS8
## 12                                                                                                                         CREB5, SMARCC2, SMARCD1, ACTL6A, DPF1, PRKAA1, PRKAA2, PRKAG1, PRKAG3, FGFR1, SOS2, MLST8, ACSL3, NDUFS3, NDUFS4, NDUFS6, NDUFS8, NDUFV1, NDUFA2, NDUFA5, NDUFA9, NDUFA12, NDUFB4, NDUFB5, NDUFB9, UQCRC1, UQCR10, COX6A1, COX6C, COX8A, ATP5PD, ATP5MF, ATP5MG, CPT2
## 14                                                                                                                                                                                                NDUFS3, NDUFS4, NDUFS6, NDUFS8, NDUFV1, NDUFA2, NDUFA5, NDUFA9, NDUFA12, NDUFB4, NDUFB5, NDUFB9, UQCRC1, UQCR10, COX6A1, COX6C, COX8A, ATP5PD, ATP5MF, ATP5MG, ATP6V1A, ATP6V1D, ATP6V0B, PPA1
## 18                                                                                                                                                                                                                            MAPK9, CPT2, PIK3CB, NDUFV1, NDUFA2, NDUFA5, NDUFA9, NDUFA12, NDUFB4, NDUFB5, NDUFB9, NDUFS3, NDUFS4, NDUFS6, NDUFS8, UQCRC1, UQCR10, COX6A1, COX6C, COX8A, ATP5PD
## 21                                                                                                                                                                           GSTT1, MGST3, NDUFV1, NDUFA2, NDUFA5, NDUFA9, NDUFA12, NDUFB4, NDUFB5, NDUFB9, NDUFS3, NDUFS4, NDUFS6, NDUFS8, UQCRC1, UQCR10, COX6A1, COX6C, COX8A, ATP5PD, SOD2, AKR1A1, NOX4, SOS2, MAPK9, PIK3CB, PRKD2, NFE2L2
## 3                                                                                                                                                                                                                          SMAD4, PRKAA1, PRKAA2, PRKAG1, PRKAG3, SKP2, SETD7, MAPK9, PIK3CB, FOXO1, FOXO6, IL10, SOS2, CDK2, CCNB1, CCND1, CCNG2, CDKN1A, PLK1, PLK4, SOD2, G6PC3, S1PR1, S1PR4
## 4                                                                                                                                                                                                                                                           PSMD3, PSMD9, PSMD11, PSMD6, PSMD7, PSMC1, PSMC5, PSMC6, PSMC3, PSMC4, PSME3, PSMA5, PSMA1, PSMA3, PSMB6, PSMB3, PSMB5, PSMB1, PSMB4
## 15                                                                                                                                                                                                       PSMA5, PSMA1, PSMA3, PSMB6, PSMB3, PSMB5, PSMB1, PSMB4, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD3, PSMD9, PSMD11, PSMD6, PSMD7, TRAF2, MAPK9, ATXN1L, TBPL1, NRBF2, WIPI2, WIPI1, PIK3CB
## 5                                                                                       CCND1, E2F1, E2F4, TFDP2, SMAD4, ZBTB17, CDKN2C, CDKN1A, CCNE1, CDK2, SKP1, SKP2, CCNA2, CDC45, CDC7, CDK1, CCNB1, PLK1, PKMYT1, ANAPC2, ANAPC4, ANAPC7, ANAPC10, ANAPC11, CDC26, ANAPC13, ANAPC15, PTTG1, ESPL1, BUB3, MAD2L1, MAD2L2, CHEK1, SFN, ORC1, ORC2, ORC3, ORC5, ORC6, MCM2, MCM4, MCM5, MCM7
## 7                                                                                                                                                                                                                  PKMYT1, CDK1, CDK2, PLK1, SKP1, ANAPC2, ANAPC4, ANAPC7, ANAPC10, ANAPC11, CDC26, ANAPC13, ANAPC15, FBXO43, PTTG1, ESPL1, CCNB1, MAD2L1, MAD2L2, CCNE1, PPP2CA, PPP2CB, PPP3CB
## 11                                                                                                                                                                                                                                                      PIK3CB, MAPK9, CDK2, CDK1, CCNA2, PKMYT1, CCNB1, PLK1, MAD2L1, MAD2L2, ANAPC2, ANAPC4, ANAPC7, ANAPC10, ANAPC11, CDC26, ANAPC13, ANAPC15
## 24                                                                                                                                                                                                                                                 UBE2D2, SMURF1, TRAF6, MAP3K1, BIRC2, SKP1, SKP2, ELOC, CUL4B, CUL5, SOCS3, ANAPC11, ANAPC2, ANAPC4, ANAPC7, ANAPC10, CDC26, ANAPC13, ANAPC15
## 6                                                                                                                                                                                                                                                                       CHEK1, CDKN1A, CCND1, CCNE1, CDK2, SFN, CCNB1, CDK1, GTSE1, TNFRSF10A, BCL2L1, EI24, SERPINE1, CD82, RRM2, STEAP3, CCNG2
## 10                                                                                                                                                                                                                                                                                             MTMR1, MTMR8, MTMR14, INPP5F, INPP5E, PIK3CB, PIK3CG, FIG4, IMPA2, ISYNA1, INPP1, INPP5K, ALDH6A1
## 13                                                                                                                                                                                                                                                                                                                            INPP5F, INPP5E, PIK3CB, MTMR1, MTMR8, MTMR14, PIP4P2, INPP1, IMPA2
## 16                                                                                                                                                                                                                                                                                                     NUDT5, PGM2, NT5DC4, IMPDH2, ENTPD4, RRM2, HDDC2, HDDC3, PDE1B, PDE6A, PDE10A, AK4, PDE8A
## 23                                                                                                                                                                                                                                                                                                                                                  ENTPD4, UCK1, NT5DC4, RRM2, HDDC2, TK1, UPB1
## 17                                                                                                                                                                                                                                                                                                                          IL10, STAT2, SOCS3, BCL2L1, PIM1, CCND1, CDKN1A, STAM2, SOS2, PIK3CB
## 19                                                                                                                                                                                                                                                        FGF2, FGF23, CSF1, EFNA3, EFNA5, FGFR1, FLT4, SOS2, RRAS2, RASA1, RASA2, RAC3, PAK4, PIK3CB, BCL2L1, RGL1, RGL2, MAPK9, PLA2G1B, RAB5A
## 39                                                                                                                                                                                                      PPP3CB, RASA1, RASA2, FGF2, FGF23, CSF1, EFNA3, EFNA5, FGFR1, FLT4, SOS2, RRAS2, MKNK1, RAC3, TRAF2, IRAK1, TRAF6, STK3, MAP3K1, MAP3K7, MAPK9, DDIT3, DUSP1, DUSP4, DUSP2, DUSP5, DUSP6
## 58                                                                                                                                                                                                                                                                                        F2R, ADORA2A, FGF2, FGF23, CSF1, EFNA3, EFNA5, FGFR1, FLT4, RAPGEF6, PRKD2, RAC3, TLN2, ITGA2B, PIK3CB
## 20                                                                                                                                                                                                                                                                                                                   PIK3CB, CREB5, FOXO1, SOD2, ADIPOR1, CAMKK2, PRKAA1, PRKAA2, PRKAG1, PRKAG3
## 25                                                                                                                                                                                                                                                                                                    PPP1R3B, PIK3CB, SOCS3, MAPK9, PRKAA1, PRKAA2, PRKAG1, PRKAG3, FOXO1, G6PC3, SLC2A2, CREB5
## 27                                                                                                                                                                                                                                 MAP3K7, CAMKK2, ADIPOR1, PRKAA1, PRKAA2, PRKAG1, PRKAG3, PFKFB3, FBP2, G6PC3, CREB5, CCND1, CCNA2, FOXO1, SCD5, PPP2CA, PPP2CB, PPP2R3C, RAB2A, RAB8A, PIK3CB
## 29                                                                                                                                                                                                                                                                                                              CREB5, PPP4C, PPP3CB, FOXO1, G6PC3, PRKAA1, PRKAA2, PRKAG1, PRKAG3, SLC2A2, FBP2
## 46                                                                                                                                                                                                                                                                                  PIK3CB, PPP1R3B, FLOT2, FLOT1, PRKAA1, PRKAA2, PRKAG1, PRKAG3, FOXO1, G6PC3, FBP2, SOS2, MKNK1, SOCS3, MAPK9
## 47                                                                                                                                                                                                                                                                                                                                           PIK3CB, FOXO1, SOD2, PRKAA1, PRKAA2, PRKAG1, PRKAG3
## 61                                                                                                                                                                                                                                                                   C5AR1, IRAK1, TRAF6, MAP3K7, SCD5, ADIPOR1, CAMKK2, PRKAA1, PRKAA2, PRKAG1, PRKAG3, FOXO1, FABP1, ALDH2, NOX4, CCND1, MAPK9
## 71                                                                                                                                                                                                                                                                                                            TRAF2, MAPK9, SOCS3, ACSL3, G6PC3, ADIPOR1, CAMKK2, PRKAA1, PRKAA2, PRKAG1, PRKAG3
## 22                                                                                                                                                     TLN2, XPO1, PPP3CB, MAD2L1, BUB3, ANAPC2, ANAPC4, ANAPC7, ANAPC10, ANAPC11, CDC26, ANAPC13, ANAPC15, PTTG1, ESPL1, CCND1, CDKN1A, CCNA2, CCNE1, CDK2, E2F1, CHEK1, PIK3CB, MAP3K1, MAPK9, BCL2L1, SMAD4, TBPL1, EGR1, EGR2, CREB5, CDKN2C
## 65                                                                                                                                                                                                                                                                           CREB5, PIK3CB, CCNE1, CDK2, EGR2, EGR3, CDKN1A, CDK1, TBPL1, CCND1, CCNA2, SKP2, TRAF2, PSMC1, HDAC10, RASA2, CHEK1
## 26                                                                                                                                                                                                                                                                                                                                                 FABP1, HMGCS1, SCD5, ACSL3, CPT2, PLIN4, AQP7
## 147                                                                                                                                                                                                                                                                                                                                              ACAT2, ACAT1, ECHS1, ACSL3, CPT2, CYP2U1, ALDH2
## 28                                                                                                                               RAB5A, RAB7B, DYNLL1, DYNLRB1, DCTN2, DCTN3, DCTN6, ACTR1B, ACTR10, TUBB3, TUBB4A, FYCO1, ARL8A, KLC2, RAB9B, STX10, ELMO2, CYFIP1, BRK1, ACTR3, ARPC1A, ARPC2, PIK3CB, PIK3CG, IRAK1, TRAF6, MAP3K7, CSE1L, KPNA3, MAPK9, SKP1, TRAF2, BIRC2, TNFRSF10A, CASP7
## 49                                                                                                                                                                                                                                    ELMO2, ACTR3, ARPC1A, ARPC2, TLN2, PIK3CB, FOXO1, FOXO6, GSK3A, BCL2L1, TRAF2, MAP3K7, TRAF6, MAPK9, UBE2D2, SKP1, MAP1LC3B, SEPTIN3, WIPI2, WIPI1, TECPR1
## 57                                                                                                                                                                                                                                                                                  FN1, ELMO2, RAC3, ACTR3, ARPC1A, ARPC2, WIPF3, GIT2, SKAP2, IRAK1, TRAF6, TRAF2, MAP3K7, MAPK9, PIK3CB, IL10
## 74                                                                                                                                                                                                                                                         CYFIP1, BRK1, ACTR3, ARPC1A, ARPC2, F2R, ARHGEF11, TUBB3, TUBB4A, WIPF3, IRAK1, TRAF6, TRAF2, MAP3K7, MAPK9, TNFRSF10A, CASP7, SEC24B
## 30                                                                                                                                                                                                                                                                                                          TRAF2, BIRC2, MAP3K7, MAPK9, CREB5, CASP10, CASP7, CSF1, SOCS3, JUNB, PIK3CB, DAB2IP
## 31                                                                                                                                                                                                                                                              SKP1, PIK3CB, PPP3CB, RAC3, PAK4, BCL2L1, IRAK1, TRAF6, MAP3K7, MAPK9, TRAF2, TAP1, AP1S2, ELOC, CUL5, CUL4B, CHEK1, CCNB1, CDK1
## 37                                                                                                                                                                                                                                                                                                                 PIK3CB, SOS2, RAC3, TRAF2, PPP3CB, ARHGEF11, CCND1, CREB5, TAP1, CDKN1A, E2F1
## 45                                                                                                                                                                                                                                                                                                              CSF1, PIK3CB, TNFRSF11A, TRAF2, TRAF6, MAP3K7, MAPK9, JUNB, PPP3CB, STAT2, SOCS3
## 52                                                                                                                                                                                                                                                               PIK3CB, BCL2L1, MAPK9, SOD2, CYP2A6, HSPD1, IRAK1, TRAF6, MAP3K7, HSPA5, DDIT3, EIF2S1, TRAF2, NFE2L2, PPP3CB, TNFRSF10A, CASP7
## 73                                                                                                                                                                                                                                                                                                        TLR3, STAT2, TRAF2, CDKN1A, E2F1, MAP1LC3B, PIK3CG, PIK3CB, MAPK9, PPP3CB, FGF2, CCND1
## 85                                                                                                                                                                                                                                                                      TNFRSF10A, CASP10, CASP7, HTRA2, SPTAN1, LMNB2, PARP2, PARP3, TRAF2, EIF2S1, DDIT3, BIRC2, BCL2L1, DAB2IP, MAPK9, PIK3CB
## 32                                                                                                                                                                                                                                                                                                                                 IRAK1, TRAF6, TRAF2, BIRC2, TNFRSF11A, MAP3K7, BCL2L1, CSNK2B
## 33                                                                                                                                                                                                                                                                                                                  SLC18A1, PPP3CB, CREB5, MAPK9, KCNJ5, PPP2CA, PPP2CB, PPP2R3C, GSK3A, LRTOMT
## 55                                                                                                                                                                                                                                                                                                                                                                    CREB5, PIK3CB, MAPK9, SOS2
## 56                                                                                                                                                                                                                                                                                                                                                                      PAX8, CREB5, HSPA5, LRP2
## 60                                                                                                                                                                                                                                                                                                                          SLC8A3, PPP2CA, PPP2CB, PPP2R3C, MYH6, AGTR2, PPP1R1A, CREB5, PIK3CG
## 64                                                                                                                                                                                                                                                                                                                                               CREB5, SOS2, PIK3CB, JUNB, SOCS3, MAP3K1, MAPK9
## 68                                                                                                                                                                                                                                                                                                                                                                          SLC2A2, KCNN1, CREB5
## 76                                                                                                                                                                                                                                                                                                                                                   KCNJ4, CHRM4, PIK3CG, CHRNA7, CREB5, PIK3CB
## 82                                                                                                                                                                                                                                                                                                                                                                           PRKD2, CREB5, KCNJ5
## 95                                                                                                                                                                                                                                                                                                                                            FGF23, FGFR1, EGR1, CREB5, CDKN1A, ARHGEF11, MMP25
## 101                                                                                                                                                                                                                                                                                                                                                                   CREB5, SOS2, PIK3CB, KCNJ5
## 111                                                                                                                                                                                                                                                                                                                                                                                 PDE8A, CREB5
## 121                                                                                                                                                                                                                                                                                                                                                                  KCNJ5, KCNN1, PIK3CB, GNRH2
## 133                                                                                                                                                                                                                                                                                                                                   ADRA2A, ADRA2B, PPP3CB, MYH6, SLC8A3, CNGB1, PIK3CG, CREB5
## 34                                                                                                                                                                                                                                                                      TLR3, TRAF6, EIF2AK1, EIF2S1, SOCS3, STAT2, RSAD2, PPP2CA, PPP2CB, SOS2, PIK3CB, CDKN1A, CDK2, E2F1, TRAF2, PSME3, CCND1
## 40                                                                                                                                                                                                                                                            CDKN1A, MAPK9, EGR2, EGR3, MAP3K1, PIK3CB, CASP10, CCNA2, CDK2, CCNE1, E2F1, STAT2, SOS2, SMAD4, CREB5, IRAK1, TRAF6, MAP3K7, TLR3
## 42                                                                                                                                                                                                                                                                                        IRAK1, TRAF6, CSNK2B, MAP3K7, MAPK9, STAT2, EIF2AK1, RAB9B, EIF2S1, BCL2L1, CCND1, CCNE1, CDK2, PIK3CB
## 43                                                                                                                                                                                                           IRAK1, TRAF6, MAP3K7, STAT2, ISG15, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD3, PSMD11, PSMD6, PSMD7, TAP1, HES1, CDKN1A, PIK3CB, MAPK9, TRAF2, SKP2, CCND1, CCNA2, CCNE1, CDK2, E2F1
## 53                                                                                                                                                                                                                                                                   CDKN1A, ZBTB17, CCND1, CKS1B, CKS2, SKP2, CDK2, CCNE1, E2F1, LAMA4, LAMB3, FN1, ITGA2B, PIK3CB, BIRC2, BCL2L1, TRAF2, TRAF6
## 135                                                                                                                                                                                                                                                                                                                           DNAJC3, EIF2S1, TLR3, SOCS3, STAT2, PIK3CB, TNFRSF10A, RSAD2, XPO1
## 35                                                                                                                                                                                                                                                                                                                                   IRAK1, TRAF6, MAPK9, PPP2CA, PPP2CB, IL10, PIK3CB, SERPINE1
## 50                                                                                                                                                                                                                                                                                                                        IRAK1, TRAF6, MAP3K7, MAPK9, BCL2L1, BIRC2, LAMA4, LAMB3, PIK3CG, IL10
## 70                                                                                                                                                                                                                                                                                                                                                     TLR3, PIK3CB, IRAK1, TRAF6, MAP3K7, MAPK9
## 83                                                                                                                                                                                                                                                                                                 CASP10, IL10, HSPA9, HSPD1, IRAK1, TRAF6, MAPK9, PLA2R1, SPHK2, RAB5A, ATP6V0B, LAMP1, PPP3CB
## 86                                                                                                                                                                                                                                                                                                                           PIK3CB, IRAK1, TRAF6, MAP3K7, MAPK9, TLR3, ISG15, STAT2, C5AR1, C1S
## 99                                                                                                                                                                                                                                                                                                                                                          IRAK1, TRAF6, MAP3K7, IL10, MARCKSL1
## 112                                                                                                                                                                                                                                                                                                                                                        CASP7, C1S, IRAK1, TRAF6, MAPK9, IL10
## 130                                                                                                                                                                                                                                                                                                                                        RRAS2, PPP3CB, IL10, EGR2, EGR3, MAPK9, STAT2, PIK3CB
## 36                                                                                                                                                                                                                                                                                                                                          MED4, MED16, MED24, MED1, CCND1, MYH6, PIK3CB, FOXO1
## 160                                                                                                                                                                                                                                                                                                                         MAP3K7, PIK3CB, C5AR1, ITGA2B, GP1BA, H2AX, MACROH2A2, H2AZ1, HDAC10
## 38                                                                                                                                                                                                                                                                                                                                                     SOS2, PIK3CB, MAP3K1, MAPK9, TRAF6, IRAK1
## 63                                                                                                                                                                                                                                                                                                                                                              GNRH2, MAP3K1, MAPK9, SOS2, EGR1
## 98                                                                                                                                                                                                                                                                                                                                                                    HTR2B, HRH1, MAPK9, PIK3CB
## 41                                                                                                                                                                                                                                                                                                                               CASP10, TRAF2, MAP3K7, TRAF6, MAP3K1, MAPK9, ISG15, SIKE1, PIN1
## 48                                                                                                                                                                                                                                                                                                                           MAP3K7, MAPK9, MAP1LC3B, BIRC2, TRAF2, TRAF6, BCL2L1, GPRC6A, STAT2
## 54                                                                                                                                                                                                                                                                                                                                       TRAF6, MAP3K7, MAPK9, MAPK4, MAPK6, MAPK15, TRAF2, LCN2
## 44                                                                                                                                                                                                                                                                                                                                                                   NT5DC4, SIRT2, SIRT4, SIRT7
## 51                                                                                                                                                                                                                                                                                          DEGS1, SMPD1, ASAH2, TRAF2, MAPK9, PPP2CA, PPP2CB, PPP2R3C, PIK3CB, SPHK2, S1PR1, RAC3, S1PR3, S1PR4
## 59                                                                                                                                                                                                                                                                                    SLC8A3, RRAS2, PIK3CG, EGR1, CCND1, MAP1LC3B, PRKAA1, PRKAA2, PRKAG1, PRKAG3, SPHK2, SMAD4, CCN2, SERPINE1
## 127                                                                                                                                                                                                                                                                                                          CCND1, KCNJ4, PPP3CB, CAMKK2, PRKAA1, PRKAA2, PRKAG1, PRKAG3, PIK3CG, KCNJ5, CDKN1A
## 62                                                                                                                                                                                                                                                                                                                    GSTP1, CDK2, CCNE1, E2F1, FGFR1, PIK3CB, FOXO1, CDKN1A, CREB5, CCND1, SOS2
## 75                                                                                                                                                                                                                                                                                                                                                                     PIK3CB, RAC3, MAPK9, SOS2
## 79                                                                                                                                                                                                                                                                                                                         PIK3CB, RAC3, BCL2L1, MAPK9, CCND1, E2F1, CDKN1A, SMAD4, BRCA2, RAD51
## 81                                                                                                                                                                                                                                                                                                                                          PIK3CB, SOS2, MAPK9, CCND1, SOCS3, TNFRSF11A, SLC2A2
## 89                                                                                                                                                                                                                                                                                                                                                             CCND1, E2F1, PIK3CB, SOS2, CDKN1A
## 100                                                                                                                                                                                                                                                                                                                                                            PAK4, MAPK9, SOS2, PIK3CB, CDKN1A
## 102                                                                                                                                                                                                                                                                                                                                                                  SPHK2, PPP3CB, PIK3CB, RAC3
## 106                                                                                                                                                                                                                                                                                                                                                      PIK3CB, SOS2, PIM1, CCNA2, DUSP6, CCND1
## 108                                                                                                                                                                                                                                                                                                                                              FGF2, FGF23, FGFR1, CCND1, PIK3CB, CDKN1A, E2F1
## 113                                                                                                                                                                                                                                                                                                                                             PIK3CB, BCL2L1, SOS2, CDKN1A, CCND1, E2F1, SMAD4
## 115                                                                                                                                                                                                                                                                                                                                                            SOS2, PIK3CB, CDKN1A, CCND1, E2F1
## 119                                                                                                                                                                                                                                                                                                                                              CCND1, PIK3CB, RAC3, MAPK9, SMAD4, CDKN1A, SOS2
## 128                                                                                                                                                                                                                                                                                                                                                            SOS2, MAPK9, PIK3CB, RAC3, LYPLA1
## 131                                                                                                                                                                                                                                                                                                                                                                  PIK3CB, SOS2, CCND1, CDKN1A
## 134                                                                                                                                                                                                                                                                                                                                                             RAC3, PPP3CB, SOS2, PIK3CB, CD22
## 140                                                                                                                                                                                                                                                                                                                                                             ELOC, PIK3CB, SOS2, PAK4, CDKN1A
## 146                                                                                                                                                                                                                                                                                                                                                PIK3CB, MARCKSL1, SPHK2, ACTR3, ARPC1A, ARPC2
## 166                                                                                                                                                                                                                                                                                                                                                        RAC3, PIK3CB, SOS2, PPP3CB, TNFRSF10A
## 66                                                                                                                                                                                                                                                                                                                                                CCR9, STAT2, SOS2, PIK3CB, PIK3CG, GSK3A, RAC3
## 67                                                                                                                                                                                                                                                                                                                           SMAD4, FN1, NOX4, SERPINE1, MAPK9, PIK3CB, FOXO1, PIM1, CCND1, EGR1
## 69                                                                                                                                                                                                                                                                F2R, FGF2, FGF23, FGFR1, FN1, ITGA2B, CHRM4, SOS2, RRAS2, PIK3CB, RAC3, PAK4, GIT1, CYFIP1, BRK1, ACTR3, ARPC1A, ARPC2, IQGAP3
## 155                                                                                                                                                                                                                                                                                           COL9A3, LAMA4, LAMB3, FN1, ITGA2B, FLT4, TLN2, PIK3CB, RAC3, PAK4, MAPK9, CAV1, SOS2, CCND1, BIRC2
## 72                                                                                                                                                                                                                                                                                       RRAS2, CCND1, PIK3CB, CAV1, CDKN1A, TIMP3, SDC1, FN1, FZD2, FZD8, SDC4, FGF2, FGFR1, SOS2, WNT5A, WNT11
## 91                                                                                                                                                                                                                                                                                                                                                                MC1R, WNT5A, WNT11, FZD2, FZD8
## 107                                                                                                                                                                                                                                                                                                                     KLF4, PIK3CB, SMAD1, SMAD5, SMAD4, WNT5A, WNT11, FZD2, FZD8, FGF2, FGFR1
## 109                                                                                                                                                                                                                                                                                     CCND1, FGF2, FGF23, FGFR1, SOS2, PIK3CB, DLL3, HES1, FLT4, CDKN1A, WNT5A, WNT11, FZD2, FZD8, E2F1, BRCA2
## 110                                                                                                                                                                                                                                                                                           CDX2, CDKN1A, WNT5A, WNT11, FZD2, FZD8, CCND1, SOS2, PIK3CB, CDK2, CCNE1, E2F1, SMAD4, FGF2, FGF23
## 120                                                                                                                                                                                                                                                                                   CREB5, MEN1, ASH2L, RBBP5, WDR5, CDKN2C, CCND1, E2F1, CDK2, CCNE1, CDKN1A, PDE8A, WNT5A, WNT11, FZD2, FZD8
## 150                                                                                                                                                                                                                                           ATP6V1A, ATP6V1D, LAMTOR2, LAMTOR5, FNIP2, CASTOR2, SEH1L, SEC13, NPRL2, SKP2, MLST8, TTI1, PRKAA1, PRKAA2, WNT5A, WNT11, FZD2, FZD8, SOS2, PIK3CB
## 154                                                                                                                                                                                                                                       SOS2, PIK3CB, BCL2L1, E2F1, CDKN1A, CCND1, SMAD4, WNT5A, WNT11, FZD2, FZD8, NFE2L2, GSTT1, MGST3, GSTP1, TXNRD3, ACTL6A, SMARCD1, DPF1, SMARCC2, ARID2
## 77                                                                                                                                                                                                         PIK3CB, RRAS2, MLST8, PPP2CA, PPP2CB, WIPI2, WIPI1, RAB8A, PRKAA1, PRKAA2, MAPK9, BCL2L1, NRBF2, TRAF6, CAMKK2, MAP3K7, EIF2S1, MTMR14, RAB33B, MAP1LC3B, ATG4B, LAMP1, RAB7B, SNAP29
## 78                                                                                                                                                                                                                                                                                                       CHRNA7, E2F1, CCND1, PIK3CB, FGF2, CREB5, SOS2, KLF4, DLL3, PTGES3, KPNA3, GSTT1, MGST3
## 80                                                                                                                                                                                                                                                                                                                                                                   SLC2A2, PDK1, FGFR1, PIK3CB
## 142                                                                                                                                                                                                                                                                                                                                          MKNK1, PIK3CB, ELOC, SERPINE1, PDK1, PFKFB3, CDKN1A
## 163                                                                                                                                                                                                                                                                                                                                                                        SLC2A2, G6PC3, PIK3CB
## 84                                                                                                                                                                                                                                                                                                                             MAPK9, NBR1, MAP1LC3B, BCL2L1, CSNK2B, FUNDC1, E2F1, RRAS2, RAB7B
## 87                                                                                                                                                                                                                                      CCND1, E2F1, E2F4, PIK3CB, FOXO1, CDKN1A, CDK2, CCNE1, RRAS2, CCNA2, LIN37, RBBP4, CDK1, CCNB1, RAD50, RAD9A, RAD9B, RAD1, HUS1, CHEK1, SERPINE1, PPP3CB
## 88                                                                                                                                                                                                                                                                                                                                                                 PIK3CB, TRAF6, CSNK2B, PPP3CB
## 96                                                                                                                                                                                                                                                                                                                                                                           DLL3, PPP3CB, MAPK9
## 103                                                                                                                                                                                                                                                                                                                                              PAK4, PPP3CB, SOS2, MAP3K7, MAPK9, PIK3CB, IL10
## 132                                                                                                                                                                                                                                                                                                                                                                         SMAD4, PPP3CB, MAPK9
## 90                                                                                                                                                                                                                                                                                                                                    F2R, TLN2, ITGA2B, PIK3CG, PIK3CB, GP5, GP1BA, GP9, SNAP23
## 92                                                                                                                                                                                                                                                                                                                                                                          SLC18A1, CREB5, CDK5
## 116                                                                                                                                                                                                                                                                                                                                                                       SLC18A1, CREB5, PPP3CB
## 145                                                                                                                                                                                                                                                                                                                        SLC18A1, HDAC10, H2AX, MACROH2A2, H2AZ1, ADORA2A, CREB5, SOS2, CAMKK2
## 93                                                                                                                                                                                                                                                                                                                                                                                 PDE1B, PPP3CB
## 97                                                                                                                                                                                                                                                                                                                                                                                   KCNJ5, PER1
## 122                                                                                                                                                                                                                                                                                                                                                                                       PPP3CB
## 124                                                                                                                                                                                                                                                                                                                                                                              PPP1R1A, PPP3CB
## 129                                                                                                                                                                                                                                                                                                                                                                                             
## 139                                                                                                                                                                                                                                                                                                                                                             SOS2, TUBB3, TUBB4A, CDK1, HTR2B
## 141                                                                                                                                                                                                                                                                                                                                                                               PPP2CA, PPP2CB
## 149                                                                                                                                                                                                                                                                                                                                                                 SLC18A1, HTR2B, DUSP1, KCNJ5
## 151                                                                                                                                                                                                                                                                                                                                                                                         HRH2
## 157                                                                                                                                                                                                                                                                                                                                                            PLA2G1B, ARHGEF11, ADORA2A, RAMP3
## 94                                                                                                                                                                                                                                                                                 SLC8A3, ADORA2A, HRH2, ORAI2, CHRNA7, F2R, HRH1, HTR2B, FGF2, FGF23, FGFR1, FLT4, TPCN1, SPHK2, PPP3CB, PDE1B
## 104                                                                                                                                                                                                                                                                             CAV1, SDC1, SDC4, NFE2L2, GSTT1, MGST3, GSTP1, PRKAA1, PRKAA2, PIK3CB, ITGA2B, DUSP1, MAP3K7, MAPK9, RAC3, SUMO3
## 105                                                                                                                                                                                                                                                                                                                                                                          CDKN1A, CCND1, E2F1
## 159                                                                                                                                                                                                                                                                                                                                                                   NCOA4, PAX8, CDKN1A, CCND1
## 114                                                                                                                                                                                                                                                                                                            TRAF2, BIRC2, MAPK9, SMPD1, VPS4A, TNFRSF10A, STAT2, TLR3, H2AX, MACROH2A2, H2AZ1
## 117                                                                                                                                                                                                                                                                                                                                                           CASP7, BCL2L1, HTRA2, BIRC2, MAPK9
## 118                                                                                                                                                                                                                                                                                                                                      SOS2, RRAS2, PIK3CB, AGPAT2, AGPAT3, SPHK2, F2R, PIK3CG
## 123                                                                                                                                                                                                                                                     AMOTL1, AMOTL2, LLGL1, PPP2CA, PPP2CB, MAP3K1, MAPK9, CCND1, ACTR3, ARPC1A, ARPC2, PRKAA1, PRKAA2, PRKAG1, PRKAG3, RAB8A, RAB8B, RAPGEF6
## 125                                                                                                                                                                                                                                                                                                    GREM1, BMP7, AMHR2, SMAD1, SMAD5, SMAD4, SMURF1, E2F4, TGIF2, PITX2, SKP1, PPP2CA, PPP2CB
## 126                                                                                                                                                                                                                                                         AP2A1, AP2S1, SH3GLB2, EPS15, TRAF6, RNF41, SMURF1, ACTR3, ARPC1A, ARPC2, WIPF3, STAM2, VPS4A, CAV1, RAB5A, RUFY1, RAB8A, GIT1, GIT2
## 136                                                                                                                                                                                                                                                                                                                                           MYH6, UQCRC1, UQCR10, COX6A1, COX6C, COX8A, SLC8A3
## 137                                                                                                                                                                                                                                                                                            PPP3CB, RAC3, PAK4, LRIG2, EFNA3, EFNA5, RASA1, SEMA3G, DPYSL5, CDK5, SEMA4F, WNT5A, PIK3CB, BMP7
## 138                                                                                                                                                                                                                                                                                                                                                                                         IL10
## 143                                                                                                                                                                                                                                                                                                                    BHLHE40, BHLHE41, PER1, CRY2, NPAS2, PRKAA1, PRKAA2, PRKAG1, PRKAG3, SKP1
## 156                                                                                                                                                                                                                                                                                                                                         ITGA2B, MYH6, PRKAA1, PRKAA2, PRKAG1, PRKAG3, SLC8A3
## 144                                                                                                                                                                                                                                                                                                                                                       MAPK9, GIT1, ATP6V1A, ATP6V1D, ATP6V0B
## 152                                                                                                                                                                                                                                                                                                                                                                    ATP6V1A, ATP6V1D, ATP6V0B
## 148                                                                                                                                                                                                                                                                                          WNT5A, WNT11, FZD2, FZD8, CSNK2B, RUVBL1, SMAD4, MAP3K7, CCND1, SKP1, PRICKLE1, RAC3, MAPK9, PPP3CB
## 162                                                                                                                                                                                                                                                                        LIMD1, STK3, PPP2CA, PPP2CB, LATS2, LLGL1, CCN2, SMAD4, SERPINE1, BMP7, SMAD1, WNT5A, WNT11, FZD2, FZD8, CCND1, BIRC2
## 153                                                                                                                                                                                                                                                                                                                        ADORA2A, CNGB1, RRAS2, MAPK9, RAC3, PIK3CB, CREB5, F2R, FXYD1, PDE10A
## 158                                                                                                                                                                                                                                                                                                                                                                                 PIK3CB, THY1
## 161                                                                                                                                                                                                                                                                                                                                                                                 AQP7, PIK3CB
## 164                                                                                                                                                                                                                                                                                                                                                                                             
## 165                                                                                                                                                                                                                                                                                                                                                                                TAS1R1, PDE1B
## 167                                                                                                                                                                                                                                                                                                                                                          CSF1, CD22, ITGA2B, GP9, GP1BA, GP5
## 168                                                                                                                                                                                                                                                                                                   CCNA2, DUSP6, SMAD1, CDKN2C, BIRC2, BCL2L1, NSD2, PAX8, CDKN1A, ZBTB17, MEN1, DDIT3, FOXO1
##                                                                                                                                                                                                               Down_regulated
## 1                            UBA52, RPS27A, ADRM1, CALML4, ITPR3, ATF4, NDUFA3, NDUFA6, NDUFA8, NDUFA11, NDUFA13, NDUFB2, NDUFB3, NDUFB6, NDUFS2, COX4I2, COX5B, COX7A2L, ATP5F1A, ATP5MC3, ATP5PF, PINK1, APAF1, MFN2, KLC4
## 2              ATF4, ITPR3, APAF1, NDUFA3, NDUFA6, NDUFA8, NDUFA11, NDUFA13, NDUFB2, NDUFB3, NDUFB6, NDUFS2, COX4I2, COX5B, COX7A2L, ATP5F1A, ATP5MC3, ATP5PF, ADRM1, NOTCH1, CAV2, PIK3CD, RAC2, MAPK13, CREB3, ATF6B, KLC4
## 8                                                                     TNFRSF1A, NFKB1, PIK3CD, AKT2, ADIPOR2, MAPK13, ATF4, NDUFA3, NDUFA6, NDUFA8, NDUFA11, NDUFA13, NDUFB2, NDUFB3, NDUFB6, NDUFS2, COX4I2, COX5B, COX7A2L
## 9                                                                                                           GNAQ, PLCB2, ITPR3, GNB3, GNG3, MAPK13, NDUFA3, NDUFA6, NDUFA8, NDUFA11, NDUFA13, NDUFB2, NDUFB3, NDUFB6, NDUFS2
## 12                 ADRB3, CREB3, KDM1A, SMARCA2, SMARCE1, MAPK13, PRKG2, RPS6KA1, RPS6KB1, NDUFS2, NDUFA3, NDUFA6, NDUFA8, NDUFA11, NDUFA13, NDUFB2, NDUFB3, NDUFB6, COX4I2, COX5B, COX7A2L, ATP5F1A, ATP5MC3, ATP5PF, CPT1C
## 14                                                                                                NDUFS2, NDUFA3, NDUFA6, NDUFA8, NDUFA11, NDUFA13, NDUFB2, NDUFB3, NDUFB6, COX4I2, COX5B, COX7A2L, ATP5F1A, ATP5MC3, ATP5PF
## 18                            RAC2, NFKB1, MAPK13, COL1A2, PIK3CD, AKT2, GYS2, GYS1, NDUFA3, NDUFA6, NDUFA8, NDUFA11, NDUFA13, NDUFB2, NDUFB3, NDUFB6, NDUFS2, COX4I2, COX5B, COX7A2L, ATP5F1A, ATP5MC3, ATP5PF, G6PD, PLCB2
## 21                  GSTA4, GSTT1, NDUFA3, NDUFA6, NDUFA8, NDUFA11, NDUFA13, NDUFB2, NDUFB3, NDUFB6, NDUFS2, COX4I2, COX5B, COX7A2L, ATP5F1A, ATP5MC3, ATP5PF, CYP1A1, EPHX2, NOX1, MAP2K1, MAPK13, PIK3CD, AKT2, NFKB1, ABL2
## 3                                                                                                                                  PIK3CD, AKT2, SGK3, MAP2K1, MAPK13, TNFSF10, BCL6, BNIP3, GABARAPL1, PCK2, FBXO25, FBXO32
## 4                                                                                                                                                                                                               ADRM1, PSME1
## 15                                                                                                                                                       GNAQ, PLCB2, ITPR3, ADRM1, KAT5, RB1CC1, BECN1, ATG2A, PIK3CD, AKT2
## 5                                                                                                                                                CCND3, CDK4, HDAC2, CDC27, ANAPC16, SMC3, STAG1, BUB1, FZR1, CDC14B, CDC25A
## 7                                                                                                                                                         MAP2K1, RPS6KA1, MAPK13, CDC27, ANAPC16, SMC3, BUB1, ITPR3, CALML4
## 11                                                                                                                                                 PIK3CD, MAPK13, MAP2K1, RPS6KA1, CDC25A, AKT2, BUB1, FZR1, CDC27, ANAPC16
## 24                                                                                                                                                                         UBA52, RPS27A, RCHY1, PIAS2, FZR1, CDC27, ANAPC16
## 6                                                                                                                                                                             CCND3, CDK4, PIDD1, APAF1, SESN1, SESN2, RCHY1
## 10                                                                                                                                                  MTMR2, MTMR4, PI4KA, PIK3CD, INPP5D, PIK3C2B, PLCB2, PLCG2, MINPP1, TPI1
## 13                                                                                                                           PI4KA, PIK3CD, INPP5D, MTMR2, MTMR4, PIP4P1, PIK3C2B, PLCB2, PLCG2, IP6K1, BPNT2, ITPR3, CALML4
## 16                                                                                                                                               PRPS2, NME6, NME3, ENTPD3, ENTPD8, ENTPD6, NUDT16, PDE1A, PDE5A, PDE6G, AK8
## 23                                                                                                                                                                     CAD, NME6, NME3, ENTPD3, ENTPD8, ENTPD6, CTPS1, CTPS2
## 17                                                                                                   IL21R, CLCF1, IL6ST, IL11RA, IL31RA, IL20RA, IL20RB, IL12B, JAK3, TYK2, STAT4, STAT5B, IRF9, CCND3, PIAS2, PIK3CD, AKT2
## 19                                           FGF3, NTF3, NTF4, EFNA4, FGFR3, FLT3, SHC1, PLCG2, RASGRP2, ZAP70, GNB3, GNG3, CALML4, RASAL3, RAC2, PAK3, PIK3CD, AKT2, NFKB1, TBK1, RALBP1, SHOC2, MAP2K1, PLA2G6, ETS2, ABL2
## 39                                                             CACNA1I, RASGRP2, FGF3, NTF3, NTF4, EFNA4, FGFR3, FLT3, MAP2K1, RPS6KA1, ATF4, ELK4, TNFRSF1A, RAC2, TAB2, MAP3K3, MAP3K6, MAP2K6, MAPK13, HSPB1, AKT2, NFKB1
## 58                                                                CALML4, F2RL3, P2RY1, LPAR1, LPAR3, GNAQ, PLCB2, RASGRP2, FGF3, EFNA4, FGFR3, MAGI1, LCP2, RAC2, PFN2, ARAP3, CTNND1, MAP2K1, MAP2K6, MAPK13, PIK3CD, AKT2
## 20                                                                                                                                 PIK3CD, AKT2, CREB3, ATF4, ATF6B, RB1CC1, RPS6KB1, EIF4EBP1, ADIPOR2, NFKB1, SESN1, SESN2
## 25                                                                                                                                         RPS6KA1, PPP1R3E, PIK3CD, AKT2, RPS6KB1, GYS2, GYS1, TNFRSF1A, NFKB1, PCK2, CREB3
## 27                                                                                                                           CAB39, ADIPOR2, PCK2, CREB3, EEF2K, GYS2, GYS1, CPT1C, PPP2R2A, PIK3CD, AKT2, RPS6KB1, EIF4EBP1
## 29                                                                                                                             AKT2, ATF4, CREB3, PPP4R3A, GNAQ, PLCB2, ITPR3, PCK2, CPT1C, GYS2, GYS1, PHKA2, PHKG2, CALML4
## 46                                                                                                   PIK3CD, AKT2, GYS2, GYS1, PPP1R3E, PHKG2, PHKA2, CALML4, EXOC7, TRIP10, HK1, HK2, PCK2, RPS6KB1, EIF4EBP1, SHC1, MAP2K1
## 47                                                                                                                                                                                              PIK3CD, AKT2, RPS6KB1, HDAC2
## 61                                                                                                TAB2, NFKB1, IL12B, TRAF3, TBK1, IL17RC, TNFRSF1A, RIPK1, TAB3, TRA2B, ADIPOR2, ADH5, ALDH7A1, CPT1C, AKT2, MAP2K6, MAPK13
## 71                                                                                                                                                                               TNFRSF1A, NFKB1, AKT2, PCK2, ADIPOR2, CPT1C
## 22                                                       KAT5, MAP2K1, CD4, JAK3, STAT5B, CDC27, ANAPC16, CDK4, CCND3, PIK3CD, AKT2, TNFRSF1A, CD3D, CD3E, MAP3K3, NFKB1, ELK4, ETS2, CREB3, ATF4, ATF6B, KAT2B, KAT2A, POLB
## 65                                                                                          ATF4, CREB3, ATF6B, STAT5B, PIK3CD, NFKB1, CCND3, TRAF3, TRAF5, JAK3, HDAC2, HDAC3, HDAC6, IRF9, KAT2B, KAT2A, CDK4, POLB, IL6ST
## 26                                                                                                                                                                                               ACAA1, CPT1C, ANGPTL4, PCK2
## 147                                                                                                                                                                                              ACAA1, CPT1C, ADH5, ALDH7A1
## 28                            DYNC2LI1, DYNLRB2, KLC4, M6PR, PFN2, EXOC7, FHOD1, NCKAP1L, ARPC3, PAK3, PIK3CD, PIK3C2B, TLR2, TAB2, TAB3, NFKB1, NOD1, RIPK2, MAP2K1, MAP2K6, MAPK13, FBXO22, TNFRSF1A, RIPK1, TNFSF10, AKT2
## 49  HCLS1, ARPC3, ROCK1, PFN2, PIK3CD, AKT2, RPS6KB1, PLCB2, PLCG2, ITPR3, HK1, HK2, BNIP3, TNFRSF1A, TRAF5, RIPK1, TAB2, TAB3, NFKB1, MALT1, BCL10, NOD1, RIPK2, TBK1, MAPK13, CBX3, BECN1, CALCOCO2, UBA52, RPS27A, TECPR1
## 57                                                                              RAC2, ARPC3, GNAQ, ARHGEF1, ARHGEF28, ROCK1, RPS6KA1, LIMK1, TAB2, NFKB1, MAP2K1, MAP2K6, MAPK13, TBK1, PIK3CD, AKT2, CD4, CD8A, ZAP70, LCP2
## 74                                                                                     NCKAP1L, ARPC3, ARHGEF1, MYO1F, MYO5C, LPAR1, ROCK1, HCLS1, TNFRSF1A, RIPK1, TAB2, TAB3, NFKB1, MAPK13, TNFSF10, PAK3, CLDN19, CLDN11
## 30                                                                                      TNFRSF1A, BAG4, TRAF5, RIPK1, TAB2, TAB3, MAP2K6, MAPK13, NFKB1, MAP2K1, CREB3, ATF4, ATF6B, PGAM5, NOD2, VCAM1, TRAF3, PIK3CD, AKT2
## 31                                         CD4, PIK3CD, AKT2, RPS6KB1, NFKB1, MAP2K1, GNAQ, PLCG2, ITPR3, CALML4, GNB3, GNG3, RAC2, PAK3, LIMK1, TLR2, TAB2, MAPK13, TBK1, TNFRSF1A, RIPK1, TRAF5, MAP2K6, CD3E, CD3D, AP1S1
## 37                PIK3CD, AKT2, EIF4EBP1, RPS6KB1, NFKB1, MAP2K1, RAC2, TBK1, TNFRSF1A, RIPK1, TRAF5, GNB3, GNG3, GNAQ, PLCB2, ITPR3, CALML4, CCL4, ARHGEF1, ROCK1, PTGER1, PTGER4, MAP2K6, MAPK13, ATF4, CREB3, ATF6B, CDK4
## 45                                                                                                                         PIK3CD, AKT2, TNFRSF1A, TAB2, NFKB1, MAP2K1, MAP2K6, MAPK13, FOSL2, NOX1, LCP2, PLCG2, TYK2, IRF9
## 52                                                           ARHGEF1, PIK3CD, AKT2, POU2F3, CYP1A1, NOX1, MAP2K6, MAPK13, NFKB1, VCAM1, TLR2, TAB2, TRAF3, TBK1, IL12B, ERO1A, ATF4, PLCB2, CALML4, TNFSF10, TNFRSF1A, APAF1
## 73                                                                       TRAF3, TBK1, TYK2, IRF9, MAPK13, MAP2K6, TNFRSF1A, NFKB1, CDK4, UBA52, RPS27A, BECN1, GNB3, GNG3, MAP2K1, PIK3CD, AKT2, PLCG2, ITPR3, CALML4, IL6ST
## 85                                                                                                                            TNFSF10, TNFRSF1A, APAF1, PARP4, AIFM1, ITPR3, ATF4, RIPK1, NFKB1, PIDD1, PIK3CD, AKT2, MAP2K1
## 32                                                                                                 ZAP70, PLCG2, CARD14, BCL10, MALT1, TNFRSF1A, RIPK1, TRAF5, TRAF3, TAB2, TAB3, TNFSF13B, PIDD1, NFKB1, CCL4, VCAM1, CCL13
## 33                                                                                                                                         GNAQ, PLCB2, ITPR3, CALML4, ATF4, CREB3, ATF6B, MAPK13, GNB3, GNG3, PPP2R2A, AKT2
## 55                                                                                                                   GNB3, GNG3, ATF4, CREB3, ATF6B, NFKB1, PIK3CD, MAP2K1, AKT2, COL1A2, COL4A6, RXFP3, PLCB2, MAPK13, SHC1
## 56                                                                                                                                                                  GNAQ, PLCB2, TTF1, ATF4, CREB3, ATF6B, ITPR3, GPX3, GPX8
## 60                                                                                                                                  ADRB1, ADRB2, CALML4, PPP2R2A, TPM1, MYH6, GNAQ, PLCB2, ATF4, CREB3, ATF6B, MAPK13, AKT2
## 64                                                                                                                         ATF4, CREB3, ATF6B, GNAQ, PLCB2, ITPR3, PLCG2, SHC1, MAP2K1, STAT5B, PIK3CD, AKT2, MAP2K6, MAPK13
## 68                                                                                                                                                               KCNMB2, ATF4, CREB3, ATF6B, PDX1, GNAQ, PLCB2, ITPR3, VAMP2
## 76                                                                                                                                                         GNAQ, PLCB2, ITPR3, GNB3, GNG3, MAP2K1, ATF4, CREB3, PIK3CD, AKT2
## 82                                                                                                                                                                   GNAQ, PLCB2, ITPR3, ATF4, CREB3, ATF6B, CACNA1I, CALML4
## 95                                                                                                                                                            GNAQ, PLCB2, ITPR3, GATA3, MAP2K1, CREB3, ATF4, ATF6B, ARHGEF1
## 101                                                                                                                                        NCOA1, ATF4, CREB3, ATF6B, SHC1, MAP2K1, PIK3CD, AKT2, GNAQ, PLCB2, ITPR3, CALML4
## 111                                                                                                                                                          NR5A1, ATF4, CREB3, ATF6B, CYP11B1, GNAQ, PLCB2, ITPR3, CACNA1I
## 121                                                                                                                                                                        GNAQ, PLCB2, ITPR3, CACNA1I, MAP2K1, PIK3CD, AKT2
## 133                                                                                           GNAQ, MYH6, PRKG2, KCNMB2, GTF2IRD1, PLCB2, ITPR3, ROCK1, CALML4, PDE5A, AKT2, ADRB1, ADRB2, ADRB3, ATF4, CREB3, ATF6B, MAP2K1
## 34                                                                                                               CLDN19, CLDN11, TRAF3, TBK1, RIPK1, NFKB1, TYK2, IRF9, PPP2R2A, MAP2K1, PIK3CD, AKT2, CDK4, TNFRSF1A, APAF1
## 40                                                                                                PIK3CD, AKT2, NFKB1, APAF1, JAK3, TYK2, STAT4, STAT5B, CREB3, ATF4, ATF6B, MAP2K1, TLR2, TAB2, MAP2K6, MAPK13, TRAF3, TBK1
## 42                                                                                                      TRAF3, TBK1, NFKB1, TLR2, TAB2, IL12B, TYK2, IRF9, RCHY1, APAF1, CCND3, CDK4, CD3D, CD3E, PIK3CD, AKT2, JAK3, STAT5B
## 43                                                   TLR2, TAB2, NFKB1, TRAF3, TBK1, TYK2, IRF9, APAF1, CD3E, CD3D, ADRM1, HDAC2, CIR1, TRAF5, PIK3CD, AKT2, RIPK1, MAP2K6, MAPK13, ENTPD3, ENTPD8, JAK3, PLCG2, CCND3, CDK4
## 53                                                                                                                                                             APAF1, CDK4, COL4A6, ITGA2, PIK3CD, AKT2, NFKB1, TRAF3, TRAF5
## 135                                                                                               PRSS3, NLRX1, NFKB1, CALCOCO2, TRAF3, TBK1, IL12B, TYK2, IRF9, PIK3CD, AKT2, CCND3, CDK4, TNFSF10, TNFRSF1A, APAF1, MAP2K1
## 35                                                                                                                                      TLR2, MAPK13, NFKB1, IL12B, PPP2R2A, TNFRSF1A, GNAQ, PLCB2, PIK3CD, AKT2, CD3D, CD3E
## 50                                                                                                                                                     TAB2, MAP2K6, MAPK13, NFKB1, IL12B, TLR2, TNFRSF1A, AKT2, ALOX5, TYK2
## 70                                                                                                                                  TLR2, PIK3CD, AKT2, TAB2, NFKB1, MAP2K1, MAP2K6, MAPK13, IL12B, CCL4, RIPK1, TBK1, TRAF3
## 83                                                                                                                         TNFRSF1A, APAF1, AKT2, CD74, MALT1, BCL10, NOD2, RIPK2, TLR2, NFKB1, MAPK13, IL12B, CALML4, LAMP2
## 86                                                                                                            MAS1, NFKB1, IL12B, TNFRSF1A, IL6ST, TYK2, RPS27A, UBA52, PIK3CD, PLCG2, MAPK13, TLR2, TAB2, TRAF3, TBK1, IRF9
## 99                                                                                                                                                                                          TLR2, TAB2, NFKB1, IL12B, MAPK13
## 112                                                                                                                                                                                 CALML4, NFKB1, MAPK13, IL12B, IRF8, NOD1
## 130                                                                                                                                      IL12B, PLCG2, ITPR3, CALML4, BCL10, MALT1, NFKB1, MAPK13, IRF9, IL17D, PIK3CD, AKT2
## 36                                                                                                          MAP2K1, HDAC2, HDAC3, KAT2B, KAT2A, NCOA1, MED13, MYH6, NOTCH1, NOTCH2, NOTCH3, BMP4, PLCB2, PLCG2, PIK3CD, AKT2
## 160                                                                                                                            MAP2K1, RAC2, PLCB2, PLCG2, PIK3CD, AKT2, NFKB1, TLR2, MAPK13, MACROH2A1, HDAC2, HDAC3, HDAC6
## 38                                                                                                                 NTF4, NTF3, MAP2K1, RPS6KA1, ATF4, MAP3K3, MAPK13, SHC1, PIK3CD, AKT2, NFKB1, PLCG2, CALML4, PRDM4, RIPK2
## 63                                                                                                                                                          ATF4, GNAQ, PLCB2, ITPR3, CALML4, MAP3K3, MAP2K6, MAPK13, MAP2K1
## 98                                                                                                                                   GNAQ, PLA2G6, PLCB2, ITPR3, CALML4, MAP2K6, MAPK13, PLCG2, PIK3CD, PTGER4, TRPV4, F2RL1
## 41                                                                                                                                                                     TRAF3, AZI2, TBK1, RIPK1, NFKB1, MAPK13, IL12B, NLRX1
## 48                                                                                          NOD1, RIPK2, NFKB1, NOD2, TAB2, TAB3, MAPK13, GABARAPL1, TRAF5, TRAF3, TBK1, NLRX1, PLCB2, ITPR3, DHX33, MFN2, RIPK1, TYK2, IRF9
## 54                                                                                                                        TRAF3IP2, NFKB1, CCL11, IL17RC, TRAF3, TBK1, TAB2, TAB3, MAPK13, USP25, TRAF5, IL17C, IL17B, IL17D
## 44                                                                                                                                                                                              NADSYN1, SIRT2, SIRT5, NADK2
## 51                                                                                 SPTLC1, DEGS2, SGMS2, TNFRSF1A, ACER1, MAPK13, AKT2, PPP2R2A, PIK3CD, PLCB2, SGPP2, ABCC1, SGPL1, S1PR2, MAP2K1, RAC2, GNAQ, ROCK1, NFKB1
## 59                                                                                                                                              GNB3, GNG3, GNAQ, PLCB2, ITPR3, CALML4, MAP2K1, RPS6KB1, AKT2, NOTCH3, BECN1
## 127                                                                                                                                                                         GNAQ, MAP2K1, PLCB2, EEF2K, ITPR3, CALML4, ROCK1
## 62                                                                                                                                                                          PIK3CD, AKT2, ATF4, CREB3, NFKB1, MAP2K1, SRD5A2
## 75                                                                                                                                                    INPP5D, PLCG2, PIK3CD, AKT2, RAC2, MAP2K6, MAPK13, LCP2, MAP2K1, ALOX5
## 79                                                                                                                                                                  PIK3CD, RAC2, NFKB1, AKT2, MAP2K1, RALBP1, RPS6KB1, CDK4
## 81                                                                                                                                                                   SHC1, PIK3CD, AKT2, MAP2K1, MAPK13, STAT5B, NFKB1, CSN2
## 89                                                                                                                                                                           CDK4, PIK3CD, AKT2, MAP2K1, PLCG2, JAK3, STAT5B
## 100                                                                                                                                                 PLCG2, STAT5B, ABL2, PAK3, SHC1, MAP2K1, PIK3CD, AKT2, RPS6KB1, EIF4EBP1
## 102                                                                                                                                                                 SH2D2A, PLCG2, MAP2K1, MAPK13, HSPB1, PIK3CD, RAC2, AKT2
## 106                                                                                                                                                             FLT3, PIK3CD, AKT2, NFKB1, EIF4EBP1, RPS6KB1, MAP2K1, STAT5B
## 108                                                                                                                                                                                         FGF3, MAP2K1, CDK4, PIK3CD, AKT2
## 113                                                                                                                                                                   PIK3CD, AKT2, NFKB1, MAP2K1, SHC1, STAT5B, CDK4, HDAC2
## 115                                                                                                                                                                          PLCG2, CALML4, SHC1, MAP2K1, PIK3CD, AKT2, CDK4
## 119                                                                                                                                                                                      PIK3CD, AKT2, MAP2K1, RAC2, RPS6KB1
## 128                                                                                                                                                      MAP2K1, PIK3CD, AKT2, RPS6KB1, EIF4EBP1, RAC2, CHPT1, PLPP3, GPCPD1
## 131                                                                                                                                                                                                     PIK3CD, AKT2, MAP2K1
## 134                                                                                                                                                  RAC2, PLCG2, MAP2K1, BCL10, MALT1, NFKB1, PIK3CD, AKT2, INPP5D, PIK3AP1
## 140                                                                                                                                                                                               PIK3CD, AKT2, MAP2K1, PAK3
## 146                                                                                                                                   PIK3CD, AKT2, RPS6KB1, PLCG2, MAP2K1, PLA2G6, PLPP3, ARPC3, RAC2, LIMK1, ASAP3, INPP5D
## 166                                                                                                                                                          RAC2, MAP2K1, ZAP70, LCP2, PLCG2, PIK3CD, SHC1, SH2D1B, TNFSF10
## 66                                     CXCL14, CCL4, CCL8, CCL11, CCL13, CCL15, CCL23, CCL28, CXCR6, CCR6, CCR7, JAK3, STAT5B, SHC1, MAP2K1, PIK3CD, AKT2, NFKB1, RAC2, ROCK1, GNB3, GNG3, GNAQ, PLCB2, PLCG2, RASGRP2, GRK3
## 67                                                                                                                                      COL1A2, COL4A6, NOX1, PLCB2, PLCG2, VCAM1, MAPK13, NFKB1, PIK3CD, AKT2, STAT5B, CDK4
## 69                                                                         LPAR1, FGF3, FGFR3, ITGA2, ITGB4, ITGB7, PIK3CD, MAP2K1, AKT2, ARHGEF1, RAC2, PAK3, ROCK1, LIMK1, NCKAP1L, ABI2, ARPC3, PFN2, SSH1, SSH3, SPATA13
## 155                                                                                                                  COL1A2, COL4A6, COL6A2, ITGA2, ITGB4, ITGB7, ROCK1, AKT2, PIK3CD, RAC2, PAK3, CAV2, SHC1, MAP2K1, CCND3
## 72                                                                           HCLS1, MAP2K1, ARHGEF1, ROCK1, PIK3CD, AKT2, ITPR3, RPS6KB1, CAV2, TLR2, IL12B, TFAP4, COL1A2, ITGA2, FZD5, FZD10, PLCG2, WNT9A, WNT10B, MAPK13
## 91                                                                                                                                                            CREB3, WNT9A, WNT10B, FZD5, FZD10, GNAQ, MAP2K1, PLCB2, CALML4
## 107                                                                                                                            IL6ST, JAK3, SOX2, MAP2K1, PIK3CD, AKT2, BMP4, ID4, MAPK13, WNT9A, WNT10B, FZD5, FZD10, FGFR3
## 109                                                                                                  NCOA1, FGF3, SHC1, MAP2K1, PIK3CD, AKT2, RPS6KB1, DLL3, NOTCH1, NOTCH2, NOTCH3, WNT9A, WNT10B, FZD5, FZD10, FRAT2, CDK4
## 110                                                                                                                                             WNT9A, WNT10B, FZD5, FZD10, FRAT2, SHC1, MAP2K1, PIK3CD, AKT2, RPS6KB1, FGF3
## 120                                                                                                          ATF4, CREB3, ATF6B, CDK4, MAP2K1, USP8, NR5A1, CYP11B1, GNAQ, PLCB2, ITPR3, CACNA1I, WNT9A, WNT10B, FZD5, FZD10
## 150                                                                                       FNIP1, SESN2, CASTOR1, WDR24, EIF4EBP1, RPS6KB1, CAB39, WNT9A, WNT10B, FZD5, FZD10, TNFRSF1A, MAP2K1, RPS6KA1, PIK3CD, AKT2, PRR5L
## 154                                                                                                      PLCG2, SHC1, MAP2K1, PIK3CD, AKT2, RPS6KB1, CDK4, WNT9A, WNT10B, FZD5, FZD10, FRAT2, GSTA4, GSTT1, SMARCE1, SMARCA2
## 77                                                                                            PIK3CD, AKT2, MAP2K1, BNIP3, RPS6KB1, IGBP1, RB1CC1, ATG2A, SUPT20H, TBK1, BECN1, DAPK2, MTMR4, GABARAPL1, ATG4A, LAMP2, VAMP8
## 78                                            CDC25A, PIK3CD, AKT2, NFKB1, MAP2K1, ADRB1, ADRB2, ADRB3, ATF4, CREB3, ATF6B, RPS6KA1, CCND3, EIF4EBP1, RPS6KB1, STAT5B, BCL6, NOTCH2, FGF3, DLL3, CYP1A1, EPHX2, GSTA4, GSTT1
## 80                                                                                                                                                                         FGFR3, FLT3, MAP2K1, G6PD, HK1, HK2, PIK3CD, AKT2
## 142                                                                                                                                                    NFKB1, MAP2K1, PIK3CD, AKT2, EIF4EBP1, RPS6KB1, PLCG2, HK1, HK2, PGK1
## 163                                                                                                                                                                                            HK1, HK2, PIK3CD, AKT2, PLCB2
## 84                                                                                                               ATF4, PINK1, UBA52, RPS27A, MFN2, RHOT2, USP8, CALCOCO2, NBR1, TBK1, GABARAPL1, BECN1, PGAM5, BNIP3, BNIP3L
## 87                                                                                                 CDK4, CCND3, PIK3CD, AKT2, LIN9, MAP2K1, MAP2K6, MAPK13, CDC25A, TRAF3IP2, NFKB1, EIF4EBP1, ZFP36L2, TRPV4, CALML4, ITPR3
## 88                                                                                                                         MAP2K1, PIK3CD, AKT2, RPS6KB1, NFKB1, TLR2, BATF3, CD4, CD3E, CD3D, ZAP70, MAP3K3, MAP2K6, MAPK13
## 96                                                                                                              DLL3, NOTCH3, NFKB1, IL12B, TYK2, STAT4, CD4, CD3E, CD3D, ZAP70, MAPK13, JAK3, STAT5B, GATA3, NOTCH1, NOTCH2
## 103                                                                                                                        CD3D, CD3E, CD4, CD8A, ZAP70, LCP2, PAK3, MAPK13, MAP2K1, BCL10, MALT1, NFKB1, PIK3CD, AKT2, CDK4
## 132                                                                                                                                           MAPK13, IL21R, JAK3, IL6ST, TYK2, CD4, CD3E, CD3D, ZAP70, NFKB1, GATA3, STAT5B
## 90                                                                                  TBXA2R, F2RL3, ARHGEF1, ROCK1, ITPR3, P2RY1, GNAQ, PLCB2, RASGRP2, COL1A2, ITGA2, PIK3CD, LCP2, PLCG2, AKT2, PRKG2, MAPK13, PTGS1, VAMP8
## 92                                                                                                                                                                                                 ATF4, CREB3, ATF6B, NFKB1
## 116                                                                                                                                                                                        CALML4, ATF4, CREB3, ATF6B, HDAC2
## 145                                                                                                                                     HDAC2, HDAC3, HDAC6, MACROH2A1, GNB3, GNG3, ATF4, CREB3, ATF6B, SHC1, MAP2K1, CALML4
## 93                                                                                                                                               ADRB1, ADRB2, ADRB3, PTGER4, PDE1A, EDN3, GNAQ, PLCB2, ITPR3, CALML4, PRKG2
## 97                                                                                                                                                              CALML4, ITPR3, GNB3, GNG3, CACNA1I, PRKG2, GNAQ, PLCB2, PER3
## 122                                                                                                                                                                                     GNAQ, PLCB2, ITPR3, GNB3, GNG3, GRK3
## 124                                                                                                                                                                        CALML4, ATF4, MAP2K1, RPS6KA1, ITPR3, GNAQ, PLCB2
## 129                                                                                                                                                            ADRB1, ADRB2, ADRB3, VAMP2, GNAQ, PLCB2, ITPR3, CALML4, PRKG2
## 139                                                                                                                                                                          LPAR1, MAP2K1, ADRB1, GNAQ, PLCB2, ITPR3, PRKG2
## 141                                                                                                                                                                                        PRKG2, MAP2K1, GNAQ, PLCB2, ITPR3
## 149                                                                                                                                                                     GNAQ, PLCB2, ITPR3, ALOX5, PTGS1, GNB3, GNG3, MAP2K1
## 151                                                                                                                                                                                       GNAQ, PLCB2, ITPR3, CALML4, KCNJ10
## 157                                                                                                                                                 EDN3, GNAQ, PLA2G6, KCNMB2, CALML4, PLCB2, ITPR3, MAP2K1, ARHGEF1, ROCK1
## 94                                                                                 ADRB1, ADRB2, ADRB3, CACNA1I, CASQ1, CYSLTR1, LTB4R2, PTGER1, TBXA2R, GNAQ, FGF3, FGFR3, PLCB2, PLCG2, ITPR3, CALML4, PHKG2, PHKA2, PDE1A
## 104                                                                                                         CAV2, CALML4, TRPV4, GSTA4, GSTT1, PIK3CD, AKT2, TNFRSF1A, NFKB1, MAP2K6, MAPK13, VCAM1, BMP4, NOX1, RAC2, SUMO1
## 105                                                                                                                                                                                               FGFR3, MAP2K1, DAPK2, CDK4
## 159                                                                                                                                                                                                                   MAP2K1
## 114                                                                                                         TNFRSF1A, TRAF5, RIPK1, SPATA2, PGAM5, CHMP2A, TNFSF10, JAK3, TYK2, STAT4, STAT5B, IRF9, USP21, AIFM1, MACROH2A1
## 117                                                                                                                                                                                                   TNFRSF1A, APAF1, BECN1
## 118                                                                                                                                            SHC1, PIK3CD, AKT2, PLCG2, AGPAT4, AGPAT5, MAP2K1, PLPP3, LPAR1, LPAR3, PLCB2
## 123                                                                                                                          CRB3, CLDN19, CLDN11, F11R, MPP4, TJP3, LLGL2, PPP2R2A, CDK4, HCLS1, ARPC3, ROCK1, IGSF5, MAGI1
## 125                                                                                                                                                                           NBL1, BMP4, BMP5, ZFYVE16, ID4, ROCK1, RPS6KB1
## 126                                                                                                                                         AP2A2, ZFYVE16, FGFR3, EPN1, GRK3, ARPC3, USP8, CHMP2A, CAV2, EHD3, ASAP3, ARAP3
## 136                                                                                                                                                                                       TPM1, MYH6, COX4I2, COX5B, COX7A2L
## 137                                                                                                                                 NTN1, PLCG2, RAC2, PAK3, ROCK1, EFNA4, SEMA3B, LIMK1, DPYSL2, PLXNB1, PIK3CD, SSH1, SSH3
## 138                                                                                                                                                                            TLR2, NFKB1, NOD2, IL12B, STAT4, IL21R, GATA3
## 143                                                                                                                                                                                                                     PER3
## 156                                                                                                                                                                                          ITGA2, ITGB4, ITGB7, TPM1, MYH6
## 144                                                                                                                                                                                  PLCG2, F11R, IGSF5, MAPK13, NFKB1, NOD1
## 152                                                                                                                                                                                                             ERO1A, PLCG2
## 148                                                                                      WNT9A, WNT10B, WIF1, DKK2, DKK4, SERPINF1, LGR4, LGR6, RNF43, FZD5, FZD10, FRAT2, NKD2, CTNNBIP1, SOX17, CCND3, VANGL2, RAC2, PLCB2
## 162                                                                                                                                 FRMD6, RASSF6, PPP2R2A, LLGL2, BMP4, BMP5, WNT9A, WNT10B, FZD5, FZD10, NKD2, CCND3, SOX2
## 153                                                                                                                                GPHA2, ADRB1, ADRB2, EDN3, CALML4, RAC2, ARAP3, PIK3CD, AKT2, MAP2K1, CREB3, NFKB1, ROCK1
## 158                                                                                                                                            F11R, CLDN19, CLDN11, VCAM1, PIK3CD, CTNND1, MAPK13, PLCG2, THY1, ROCK1, RAC2
## 161                                                                                                                                                                          ADRB1, ADRB2, ADRB3, PRKG2, PIK3CD, AKT2, PTGS1
## 164                                                                                                                                                                                                            RPS27A, UBA52
## 165                                                                                                                                                                                         GNB3, PLCB2, ITPR3, P2RY1, PDE1A
## 167                                                                                                                                                                    CD34, FLT3, CD2, CD4, CD8A, CD3D, CD3E, IL11RA, ITGA2
## 168                                                                                                                                                                             HDAC2, CCNT1, FLT3, BCL6, ITGB7, ELK4, NFKB1
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       all_pathway_genes
## 1                                                                                                                                                        ADORA2A, GNAL, GNAS, DRD2, GNAI1, GNAI3, GNAI2, ADCY5, PRKACA, PRKACB, PRKACG, DRD1, UBA1, UBA7, UBA52, RPS27A, UBB, UBC, UBE2L3, UBE2L6, UBE2J2, UBE2J1, UBE2G2, UBE2G1, PRKN, SNCA, GPR37, SEPTIN5, SNCAIP, PSMA6, PSMA2, PSMA4, PSMA7, PSMA8, PSMA5, PSMA1, PSMA3, PSMB6, PSMB7, PSMB3, PSMB2, PSMB5, PSMB1, PSMB4, PSMC2, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD2, PSMD1, PSMD3, PSMD9, PSMD12, PSMD11, PSMD6, PSMD7, PSMD13, PSMD4, PSMD14, PSMD8, ADRM1, SEM1, UCHL1, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, MAPT, RYR3, ITPR1, ITPR2, ITPR3, PLCG1, HSPA5, ATF6, DDIT3, ERN1, XBP1, EIF2AK3, EIF2S1, ATF4, TH, MAOB, MAOA, SLC6A3, SLC18A1, SLC18A2, SLC11A2, SLC39A2, SLC39A3, SLC39A1, SLC39A4, SLC39A5, SLC39A6, SLC39A7, SLC39A8, SLC39A9, SLC39A10, SLC39A11, SLC39A12, SLC39A13, SLC39A14, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFV1, NDUFV2, NDUFV3, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFA11, NDUFA12, NDUFA13, NDUFB1, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFB11, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFC1, NDUFC2, NDUFC2-KCTD14, SDHA, SDHB, SDHC, SDHD, UQCRFS1, CYTB, CYC1, UQCRC1, UQCRC2, UQCRH, UQCRHL, UQCRB, UQCRQ, UQCR10, UQCR11, COX3, COX1, COX2, COX4I2, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8C, COX8A, ATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP6, ATP5PB, ATP5MC1, ATP5MC2, ATP5MC3, ATP5PD, ATP5PO, ATP5PF, ATP8, PINK1, MCU, LRRK2, HTRA2, TRAP1, VDAC1, VDAC2, VDAC3, SLC25A4, SLC25A5, SLC25A6, SLC25A31, PPIF, CYCS, APAF1, CASP9, CASP3, PARK7, BCL2L1, BAX, MFN1, MFN2, KIF5A, KIF5B, KIF5C, KLC3, KLC1, KLC2, KLC4, TUBA1B, TUBA4A, TUBA3C, TUBA1A, TUBA1C, TUBA8, TUBA3E, TUBA3D, TUBAL3, TUBB6, TUBB, TUBB1, TUBB2A, TUBB3, TUBB4A, TUBB8, TUBB2B, TUBB4B, TP53, DUSP1, NFE2L2, TXN, TXN2, DAXX, MAP3K5, MAPK8, MAPK10, MAPK9, SOD1, KEAP1
## 2                                                                                                                                      PRNP, NCAM1, NCAM2, LAMC1, SOD1, STIP1, PRKACA, PRKACB, PRKACG, BAX, FYN, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S, HSPA5, EIF2AK3, EIF2S1, ATF4, DDIT3, RYR1, RYR2, RYR3, ITPR1, ITPR2, ITPR3, CASP12, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, BAD, VDAC1, VDAC2, VDAC3, SLC25A4, SLC25A5, SLC25A6, SLC25A31, PPIF, APAF1, CYCS, CASP9, CASP3, MCU, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFV1, NDUFV2, NDUFV3, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFA11, NDUFA12, NDUFA13, NDUFB1, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFB11, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFC1, NDUFC2, NDUFC2-KCTD14, SDHA, SDHB, SDHC, SDHD, UQCRFS1, CYTB, CYC1, UQCRC1, UQCRC2, UQCRH, UQCRHL, UQCRB, UQCRQ, UQCR10, UQCR11, COX3, COX1, COX2, COX4I2, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8C, COX8A, ATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP6, ATP5PB, ATP5MC1, ATP5MC2, ATP5MC3, ATP5PD, ATP5PO, ATP5PF, ATP8, PSMA6, PSMA2, PSMA4, PSMA7, PSMA8, PSMA5, PSMA1, PSMA3, PSMB6, PSMB7, PSMB3, PSMB2, PSMB5, PSMB1, PSMB4, PSMC2, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD2, PSMD1, PSMD3, PSMD9, PSMD12, PSMD11, PSMD6, PSMD7, PSMD13, PSMD4, PSMD14, PSMD8, ADRM1, SEM1, C5, C6, C7, C8A, C8B, C8G, C9, C1QA, C1QB, C1QC, HSPA8, HSPA1A, HSPA2, HSPA1L, HSPA1B, HSPA6, NOTCH1, CAV1, CAV2, CAV3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PRKCD, CYBB, CYBA, NCF4, NCF1, NCF2, RAC1, RAC2, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, MAPK1, MAPK3, CREB1, ATF2, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, EGR1, CCL5, IL1A, IL1B, IL6, TNF, GSK3B, CSNK2A1, CSNK2A2, CSNK2A3, CSNK2B, KIF5A, KIF5B, KIF5C, KLC3, KLC1, KLC2, KLC4, TUBA1B, TUBA4A, TUBA3C, TUBA1A, TUBA1C, TUBA8, TUBA3E, TUBA3D, TUBAL3, TUBB6, TUBB, TUBB1, TUBB2A, TUBB3, TUBB4A, TUBB8, TUBB2B, TUBB4B
## 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            IL6, IL6R, SOCS3, TNF, TNFRSF1A, NFKB1, RELA, INS, INSR, IRS1, IRS2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, GSK3A, GSK3B, NR1H3, RXRA, SREBF1, MLX, MLXIP, MLXIPL, PKLR, LEP, LEPR, ADIPOQ, ADIPOR1, ADIPOR2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, MAPK11, MAPK12, MAPK13, MAPK14, PPARA, PPARG, CDC42, RAC1, MAP3K11, MAPK8, MAPK10, MAPK9, ITCH, ERN1, TRAF2, MAP3K5, FOS, JUN, IL1A, IL1B, IKBKB, XBP1, CEBPA, CYP2E1, FASLG, CXCL8, TGFB1, EIF2AK3, EIF2S1, ATF4, DDIT3, BCL2L11, BAX, FAS, CASP8, BID, CYCS, CASP3, CASP7, NDUFV1, NDUFV2, NDUFV3, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFA11, NDUFA12, NDUFA13, NDUFB1, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFB11, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFC1, NDUFC2, NDUFC2-KCTD14, SDHA, SDHB, SDHC, SDHD, UQCRFS1, CYTB, CYC1, UQCRC1, UQCRC2, UQCRH, UQCRHL, UQCRB, UQCRQ, UQCR10, UQCR11, COX3, COX1, COX2, COX4I2, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8C, COX8A
## 9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     SLC17A6, SLC17A8, SLC17A7, GRIA1, GRIA2, GRIA3, GRIA4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRM1, GRM5, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, NAPEPLD, PRKCA, PRKCB, PRKCG, DAGLA, DAGLB, PTGS2, ABHD6, FAAH, CNR1, GNAI1, GNAI3, GNAI2, GNAO1, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, KCNJ3, KCNJ6, KCNJ9, KCNJ5, CACNA1A, CACNA1B, MAPK1, MAPK3, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, MGLL, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFV1, NDUFV2, NDUFV3, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFA11, NDUFA12, NDUFA13, NDUFB1, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFB11, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFC1, NDUFC2, NDUFC2-KCTD14, SLC32A1, RIMS1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB3, GABRB2, GABRG1, GABRG2, GABRG3, GABRD, GABRE, GABRQ, GABRP, GABRR1, GABRR2, GABRR3
## 12                                                                                                                                                                                                                                                                                                                                                                                                 ADRB3, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADCY10, PRKACA, PRKACB, PRKACG, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, PRDM16, ZNF516, KDM1A, UCP1, KDM3A, KDM3B, SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCD2, SMARCD3, SMARCE1, ACTG1, ACTB, ACTL6A, ACTL6B, ARID1B, ARID1A, DPF1, DPF3, PPARG, MAP3K5, MAP2K3, MAPK11, MAPK12, MAPK13, MAPK14, PPARGC1A, ATF2, SIRT6, FGF21, PLIN1, LIPE, PNPLA2, MGLL, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, GCG, BMP8B, BMP8A, CNR1, NPPA, NPPB, NPR1, PRKG1, PRKG2, KLB, FGFR1, FRS2, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, TSC1, TSC2, RHEB, RPTOR, MTOR, MLST8, AKT1S1, RPS6KB1, RPS6KB2, RPS6, ACSL6, ACSL4, ACSL1, ACSL5, ACSL3, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFA11, NDUFA12, NDUFA13, NDUFB1, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFB11, NDUFC1, NDUFC2, NDUFC2-KCTD14, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFAF6, NDUFAF7, NDUFAF8, SDHA, SDHB, SDHC, SDHD, UQCRFS1, CYTB, CYC1, UQCRC1, UQCRC2, UQCRH, UQCRHL, UQCRB, UQCRQ, UQCR10, UQCR11, COX1, COX2, COX3, COX4I2, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8C, COX8A, COX10, COX11, COX14, COX15, COX16, COX17, COX18, COX19, COX20, COA1, COA3, COA4, COA5, COA6, COA7, ATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP5PO, ATP6, ATP5PB, ATP5MC1, ATP5MC2, ATP5MC3, ATP5PD, ATP5ME, ATP5MF, ATP5PF, ATP8, ATP5MG, CPT2, SLC25A29, SLC25A20, CPT1A, CPT1B, CPT1C
## 14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFA11, NDUFA12, NDUFA13, NDUFB1, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFB11, NDUFC1, NDUFC2, NDUFC2-KCTD14, SDHA, SDHB, SDHC, SDHD, UQCRFS1, CYTB, CYC1, UQCRC1, UQCRC2, UQCRH, UQCRHL, UQCRB, UQCRQ, UQCR10, UQCR11, COX10, COX3, COX1, COX2, COX4I2, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8C, COX8A, COX11, COX15, COX17, CYCS, ATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP5PO, ATP6, ATP5PB, ATP5MC1, ATP5MC2, ATP5MC3, ATP5PD, ATP5ME, ATP5MF, ATP5MG, ATP5PF, ATP8, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C2, ATP6V1C1, ATP6V1D, ATP6V1E2, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G3, ATP6V1G2, ATP6V1H, TCIRG1, ATP6V0A2, ATP6V0A4, ATP6V0A1, ATP6V0C, ATP6V0B, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V0E2, ATP6AP1, ATP4A, ATP4B, ATP12A, PPA2, PPA1, LHPP
## 18                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               SLC2A1, SLC2A4, GFPT2, GFPT1, CAMK2A, CAMK2D, CAMK2B, CAMK2G, TNNI3, RYR2, PLN, ATP2A1, ATP2A3, ATP2A2, SP1, AGT, REN, CMA1, PRKCB, AGER, CYBB, NCF1, CYBA, NCF2, NCF4, RAC1, RAC2, AGTR1, NFKB1, RELA, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, MMP2, MMP9, COL1A1, COL1A2, COL3A1, TGFB1, TGFB2, TGFB3, CD36, PPARA, CPT1B, PDK2, PDK3, PDK4, PRKCA, PRKCD, PTPA, PPP1CA, PPP1CB, PPP1CC, CTSD, PRKCZ, CPT2, INS, INSR, IRS1, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PTEN, AKT1, AKT2, AKT3, MTOR, GSK3B, GYS2, GYS1, TBC1D4, MPC1L, MPC1, MPC2, PDHA2, PDHA1, PDHB, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFV1, NDUFV2, NDUFV3, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFA11, NDUFA12, NDUFA13, NDUFB1, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFB11, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFC1, NDUFC2, NDUFC2-KCTD14, SDHA, SDHB, SDHC, SDHD, UQCRFS1, CYTB, CYC1, UQCRC1, UQCRC2, UQCRH, UQCRHL, UQCRB, UQCRQ, UQCR10, UQCR11, COX3, COX1, COX2, COX4I2, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8C, COX8A, ATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP6, ATP5PB, ATP5MC1, ATP5MC2, ATP5MC3, ATP5PD, ATP5PO, ATP5PF, ATP8, VDAC1, VDAC2, VDAC3, SLC25A4, SLC25A5, SLC25A6, SLC25A31, PPIF, PRKCG, NOS3, GAPDH, PARP1, G6PD, GSR, TGFBR1, TGFBR2, SMAD2, SMAD3, PLCB1, PLCB2, PLCB3, PLCB4, ACE
## 21                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             AS3MT, GSTA5, GSTA2, GSTA4, GSTO2, GSTM4, GSTT2, GSTT1, GSTM3, MGST1, MGST3, GSTM1, GSTM5, MGST2, GSTA1, GSTM2, GSTA3, GSTO1, GSTT2B, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFV1, NDUFV2, NDUFV3, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFA10, NDUFAB1, NDUFA11, NDUFA12, NDUFA13, NDUFB1, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFB11, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFC1, NDUFC2, NDUFC2-KCTD14, SDHA, SDHB, SDHC, SDHD, UQCRFS1, CYTB, CYC1, UQCRC1, UQCRC2, UQCRH, UQCRHL, UQCRB, UQCRQ, UQCR10, UQCR11, COX3, COX1, COX2, COX4I2, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8C, COX8A, ATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP6, ATP5PB, ATP5MC1, ATP5MC2, ATP5MC3, ATP5PD, ATP5PO, ATP5PF, ATP8, SOD2, VDAC1, VDAC2, VDAC3, SLC25A4, SLC25A5, SLC25A6, SLC25A31, PPIF, SOD1, CAT, SLC26A1, SLC26A2, SLC26A6, SLC26A9, CYP1A2, CYP2E1, CYP2F1, CYP1A1, CYP1B1, EPHX1, EPHX2, EPHX3, EPHX4, AKR1A1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, NQO1, CBR1, AHR, LPO, NOX4, CYBA, NOX1, NCF1, NCF2, EGF, EGFR, HGF, MET, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, MAP3K5, MAP2K4, MAP2K7, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14, JUN, FOS, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, RAC1, PDPK1, AKT1, AKT2, AKT3, FOXO3, BAD, PTPN1, PTEN, CHUK, IKBKB, IKBKG, NFKBIA, RELA, NFKB1, PRKCD, PTPRJ, ACP1, PTPN11, SRC, ABL1, ABL2, PRKD1, PRKD3, PRKD2, PTK2, PLD1, PLD2, MAP3K14, HIF1A, ARNT, VEGFA, KEAP1, NFE2L2, HMOX1
## 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD4, SMAD3, STK11, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, NLK, SKP2, MDM2, SETD7, CREBBP, EP300, SIRT1, USP7, SLC2A4, MAPK8, MAPK10, MAPK9, STK4, IGF1, IGF1R, INS, INSR, IRS1, IRS2, IRS4, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PDPK1, CHUK, IKBKB, PTEN, AKT1, AKT2, AKT3, SGK1, SGK2, SGK3, C8orf44-SGK3, FOXO1, FOXO3, FOXO4, FOXO6, GRM1, HOMER1, HOMER2, HOMER3, AGAP2, CSNK1E, TPTEP2-CSNK1E, IL6, IL10, STAT3, EGF, EGFR, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, BRAF, RAF1, ARAF, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK11, MAPK12, MAPK13, MAPK14, CDK2, PRMT1, FOXG1, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCNG2, CDKN2B, CDKN2D, CDKN1A, CDKN1B, RBL2, PLK1, PLK2, PLK3, PLK4, GADD45A, GADD45B, GADD45G, FASLG, BCL2L11, TNFSF10, BCL6, BNIP3, ATG12, GABARAP, GABARAPL1, GABARAPL2, CAT, SOD2, ATM, PCK1, PCK2, G6PC1, G6PC2, G6PC3, IL7R, KLF2, S1PR1, S1PR4, RAG1, RAG2, FBXO25, FBXO32
## 4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   PSMD3, PSMD9, PSMD12, PSMD11, PSMD6, PSMD7, PSMD13, PSMD14, PSMD8, SEM1, PSMD4, PSMD2, PSMD1, ADRM1, PSMC2, PSMC1, PSMC5, PSMC6, PSMC3, PSMC4, PSME1, PSME2, PSME3, PSME4, PSMA6, PSMA2, PSMA4, PSMA7, PSMA8, PSMA5, PSMA1, PSMA3, PSMB6, PSMB7, PSMB3, PSMB2, PSMB5, PSMB1, PSMB4, PSMB9, PSMB10, PSMB8, PSMB11, IFNG, PSMF1, POMP
## 15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  TRPC3, GRM1, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, PRKCB, PRKCG, GRIA1, GRIA2, GRIA3, CACNA1A, ITPR1, ITPR2, ITPR3, ATXN2L, ATXN2, ATXN3, ATXN3L, RYR1, PDYN, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, MCU, VDAC1, VDAC2, VDAC3, SLC25A4, SLC25A5, SLC25A6, SLC25A31, PPIF, CYCS, AFG3L2, OMA1, OPA1, FGF14, SPTBN2, PSMA6, PSMA2, PSMA4, PSMA7, PSMA8, PSMA5, PSMA1, PSMA3, PSMB6, PSMB7, PSMB3, PSMB2, PSMB5, PSMB1, PSMB4, PSMC2, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD2, PSMD1, PSMD3, PSMD9, PSMD12, PSMD11, PSMD6, PSMD7, PSMD13, PSMD4, PSMD14, PSMD8, ADRM1, SEM1, ERN1, TRAF2, MAP3K5, MAPK8, MAPK10, MAPK9, ATXN1L, ATXN1, KAT5, RORA, ATP2A1, ATP2A3, ATP2A2, SLC1A6, CIC, PUM2, PUM1, TBPL2, TBPL1, TBP, RBPJL, RBPJ, SP1, GTF2B, NFYA, XBP1, MYOD1, MTOR, ULK1, ULK2, ATG101, ATG13, RB1CC1, AMBRA1, BECN1, BECN2, PIK3R4, ATG14, NRBF2, PIK3C3, ATG2A, ATG2B, WIPI2, WIPI1, KCNC3, KCND3, RELN, VLDLR, DAB1, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, TWNK, ATXN8OS, ATXN10, BEAN1, NOP56
## 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               CCND1, CCND2, CCND3, CDK4, CDK6, RB1, RBL1, RBL2, ABL1, HDAC1, HDAC2, E2F1, E2F2, E2F3, E2F4, E2F5, TFDP1, TFDP2, GSK3B, TGFB1, TGFB2, TGFB3, SMAD2, SMAD3, SMAD4, MYC, ZBTB17, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CDKN1B, CDKN1C, CDKN1A, CCNE1, CCNE2, CDK2, SKP1, CUL1, RBX1, SKP2, CCNA2, CCNA1, CDC6, CDC45, CDC7, DBF4, DBF4B, CDK1, CCNB1, CCNB2, CCNB3, CDC25B, CDC25C, YWHAZ, YWHAB, YWHAQ, YWHAE, YWHAH, YWHAG, PLK1, WEE1, WEE2, PKMYT1, CCNH, CDK7, ANAPC1, ANAPC2, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, ANAPC10, ANAPC11, CDC26, ANAPC13, ANAPC15, ANAPC16, CDC20, PTTG1, PTTG2, ESPL1, SMC1A, SMC1B, SMC3, STAG2, STAG1, RAD21, TTK, BUB1, BUB3, BUB1B, MAD1L1, MAD2L1, MAD2L2, FZR1, CDC14B, CDC14A, ATR, ATM, TP53, CHEK1, CHEK2, CREBBP, EP300, PRKDC, MDM2, GADD45A, GADD45B, GADD45G, PCNA, SFN, CDC25A, ORC1, ORC2, ORC3, ORC4, ORC5, ORC6, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7
## 7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  INS, IGF1, IGF1R, PGR, AR, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, AURKA, CPEB1, CPEB2, CPEB3, CPEB4, MOS, MAP2K1, MAPK1, MAPK3, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, PKMYT1, YWHAZ, YWHAB, YWHAQ, YWHAE, YWHAH, YWHAG, SPDYA, SPDYC, SPDYE2B, SPDYE18, SPDYE11, SPDYE16, SPDYE17, SPDYE1, SPDYE4, SPDYE3, SPDYE2, SPDYE5, SPDYE6, SPDYE15, CDK1, CDK2, MAPK11, MAPK12, MAPK13, MAPK14, PPP1CA, PPP1CB, PPP1CC, SLK, PLK1, CDC25C, CCNB2, RBX1, CUL1, SKP1, BTRC, FBXW11, FBXO5, ANAPC1, ANAPC2, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, ANAPC10, ANAPC11, CDC26, ANAPC13, ANAPC15, ANAPC16, CDC20, FBXO43, PTTG1, PTTG2, ESPL1, REC8, STAG3, SMC1A, SMC1B, SMC3, CCNB1, BUB1, MAD2L1, MAD2L2, MAD1L1, CCNE1, CCNE2, SGO1, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, PPP2R5A, PPP2R1B, PPP2R1A, PPP2CA, PPP2CB, PLCZ1, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, CAMK2A, CAMK2D, CAMK2B, CAMK2G
## 11                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           PGR, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14, GNAI1, GNAI3, GNAI2, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, AURKA, CPEB1, CPEB2, CPEB3, CPEB4, SPDYA, SPDYC, SPDYE2B, SPDYE18, SPDYE11, SPDYE16, SPDYE17, SPDYE1, SPDYE4, SPDYE3, SPDYE2, SPDYE5, SPDYE6, SPDYE15, CDK2, CDK1, CCNA2, CCNA1, MOS, HSP90AA1, HSP90AB1, MAP2K1, MAPK1, MAPK3, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, PKMYT1, CCNB1, CCNB2, CCNB3, STK10, PLK1, CDC25A, CDC25B, CDC25C, INS, IGF1, IGF1R, AKT1, AKT2, AKT3, PDE3B, KRAS, ARAF, BRAF, RAF1, BUB1, MAD1L1, MAD2L1, MAD2L2, FZR1, ANAPC1, ANAPC2, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, ANAPC10, ANAPC11, CDC26, ANAPC13, ANAPC15, ANAPC16, KIF22
## 24                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               UBB, UBC, UBA52, RPS27A, UBA1, SAE1, UBA2, UBA3, UBA7, UBA6, UBE2A, UBE2B, UBE2C, UBE2D4, UBE2D1, UBE2D2, UBE2D3, UBE2E3, UBE2E1, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2NL, UBE2N, UBE2O, UBE2Q1, UBE2Q2, UBE2QL1, UBE2R2, CDC34, UBE2S, UBE2U, UBE2W, UBE2Z, UBE2K, BIRC6, UBE3A, UBE3B, UBE3C, SMURF1, SMURF2, ITCH, WWP1, WWP2, TRIP12, NEDD4, NEDD4L, HUWE1, UBR5, HERC1, HERC2, HERC3, HERC4, UBE4A, UBE4B, STUB1, PPIL2, PRPF19, UBOX5, MDM2, CBL, CBLB, CBLC, PRKN, SIAH1, PML, TRAF6, MAP3K1, COP1, RCHY1, BIRC2, BIRC3, XIAP, BIRC7, PIAS1, PIAS2, PIAS3, PIAS4, SYVN1, NHLRC1, AIRE, MGRN1, BRCA1, FANCL, MID1, TRIM32, TRIM37, RBX1, CUL1, SKP1, BTRC, FBXW11, SKP2, FBXW7, FBXO2, FBXO4, CUL2, ELOC, ELOB, VHL, CUL3, KEAP1, KLHL9, KLHL13, RHOBTB2, RHOBTB1, CUL4B, CUL4A, DDB1, DDB2, ERCC8, DET1, RNF7, CUL5, SOCS1, SOCS3, CUL7, FBXW8, ANAPC11, ANAPC2, CDC20, FZR1, ANAPC1, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, ANAPC10, CDC26, ANAPC13, ANAPC15, ANAPC16
## 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          ATM, CHEK2, ATR, CHEK1, GORAB, CDKN2A, MDM2, MDM4, TP53, CDKN1A, CCND1, CCND2, CCND3, CDK4, CDK6, CCNE1, CCNE2, CDK2, SFN, RPRM, CCNB1, CCNB2, CDK1, GADD45A, GADD45B, GADD45G, GTSE1, FAS, PIDD1, TNFRSF10A, TNFRSF10B, CASP8, BID, BAX, PMAIP1, BBC3, TP53AIP1, SIVA1, BCL2L1, BCL2, TP53I3, EI24, SHISA5, PERP, ZMAT3, SIAH1, CYCS, APAF1, CASP9, CASP3, AIFM2, IGFBP3, IGF1, SERPINE1, ADGRB1, CD82, THBS1, SERPINB5, DDB2, RRM2B, RRM2, SESN1, SESN3, SESN2, PTEN, TSC2, STEAP3, COP1, RCHY1, CCNG1, CCNG2, PPM1D, TP73
## 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   PIK3C3, MTM1, MTMR1, MTMR2, MTMR3, MTMR4, MTMR8, MTMR6, MTMR7, MTMR14, PI4KA, PI4KB, PI4K2A, PI4K2B, SACM1L, INPP5F, PIP5K1C, PIP5K1A, PIP5K1B, PIP5KL1, OCRL, INPP5B, INPP5E, SYNJ1, SYNJ2, PIK3CA, PIK3CD, PIK3CB, PIK3CG, PTEN, INPP5D, INPPL1, PIK3C2G, PIK3C2A, PIK3C2B, INPP4A, INPP4B, PIKFYVE, FIG4, PIP4K2C, PIP4K2A, PIP4K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLCH1, PLCH2, IMPA2, IMPA1, CDIPT, ISYNA1, INPP1, INPP5A, INPP5K, INPP5J, MINPP1, ITPKB, ITPKA, ITPKC, ITPK1, IPMK, IPPK, MIOX, ALDH6A1, TPI1
## 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                PI4KA, PI4KB, PI4K2A, PI4K2B, SACM1L, INPP5F, PIP5K1C, PIP5K1A, PIP5K1B, OCRL, INPP5B, INPP5E, SYNJ1, SYNJ2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PTEN, INPP5D, INPPL1, INPP4A, INPP4B, PIKFYVE, MTM1, MTMR1, MTMR2, MTMR3, MTMR4, MTMR8, MTMR6, MTMR7, MTMR14, PIP4K2C, PIP4K2A, PIP4K2B, PIP4P1, PIP4P2, PIK3C3, PIK3C2G, PIK3C2A, PIK3C2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, IPMK, ITPKB, ITPKA, ITPKC, INPP5A, ITPK1, IPPK, IP6K1, IP6K2, IP6K3, PPIP5K1, PPIP5K2, INPP1, IMPA2, IMPA1, BPNT2, DGKZ, DGKD, DGKI, DGKA, DGKE, DGKB, DGKH, DGKG, DGKQ, DGKK, CDS1, CDS2, CDIPT, ITPR1, ITPR2, ITPR3, PRKCA, PRKCB, PRKCG, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4
## 16                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         NUDT9, ADPRM, NUDT5, PGM1, PGM2, PRPS1L1, PRPS2, PRPS1, PPAT, GART, PFAS, PAICS, ADSL, ATIC, APRT, NT5C2, NT5C1A, NT5C1B, NT5C, NT5M, NT5C1B-RDH14, NT5DC4, NT5E, PNP, LACC1, HPRT1, IMPDH1, IMPDH2, NME6, NME7, NME2, NME4, NME1, NME3, NME1-NME2, AK9, ENTPD3, ENTPD8, ENTPD1, CANT1, ENTPD4, ENTPD5, ENTPD6, NUDT16, ITPA, XDH, NUDT2, GMPS, GMPR, GMPR2, GDA, GUK1, RRM1, RRM2B, RRM2, HDDC2, DGUOK, DCK, HDDC3, PRUNE1, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADCY10, GUCY1A2, GUCY1A1, GUCY1B1, GUCY2C, GUCY2D, GUCY2F, NPR1, NPR2, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE5A, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, PDE9A, PDE10A, PDE11A, ADSS1, ADSS2, AMPD2, AMPD3, AMPD1, ADK, ADA, ADA2, AK7, AK4, AK5, AK2, AK1, AK8, AK6, AK3, ENTPD2, NTPCR, ENPP1, ENPP3, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8B, PDE8A, FHIT, ENPP4, PAPSS2, PAPSS1, URAD, ALLC
## 23                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              CAD, DHODH, UMPS, CMPK1, CMPK2, NME6, NME7, NME2, NME4, NME1, NME3, NME1-NME2, AK9, ENTPD3, ENTPD8, ENTPD1, CANT1, ENTPD4, ENTPD5, ENTPD6, ENPP1, ENPP3, ASMTL, NUDT2, CTPS1, CTPS2, UCK1, UCK2, UCKL1, NT5C2, NT5C1A, NT5C1B, NT5C, NT5M, NT5C1B-RDH14, NT5DC4, NT5E, UPP2, UPP1, NT5C3A, NT5C3B, CDA, RRM1, RRM2B, RRM2, DCTPP1, HDDC2, DCK, DCTD, DTYMK, DUT, TYMP, TK2, TK1, TYMS, DPYD, DPYS, UPB1
## 17                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         IL2, IL4, IL7, IL9, IL15, IL21, TSLP, IL2RA, IL2RB, IL2RG, IL4R, IL7R, IL9R, IL15RA, IL21R, CRLF2, IL3, IL5, CSF2, IL3RA, IL5RA, CSF2RA, CSF2RB, IL6, IL11, IL13, IL27, IL31, OSM, LIF, CNTF, CTF1, CLCF1, IL6R, IL6ST, IL11RA, IL13RA1, IL13RA2, IL27RA, IL31RA, OSMR, LIFR, CNTFR, IL10, IL19, IL22, IL20, IL24, IL26, IL10RA, IL10RB, IL20RA, IL20RB, IL22RA1, IL22RA2, IL12A, IL12B, IL23A, IL12RB1, IL12RB2, IL23R, EPO, GH1, GH2, CSH1, CSH2, PRL, THPO, CSF3, LEP, EPOR, GHR, PRLR, MPL, CSF3R, LEPR, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNE, IFNK, IFNL1, IFNL2, IFNL3, IFNW1, IFNAR1, IFNAR2, IFNLR1, IFNG, IFNGR1, IFNGR2, EGF, PDGFA, PDGFB, EGFR, PDGFRA, PDGFRB, JAK1, JAK2, JAK3, TYK2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, IRF9, CISH, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOCS6, BCL2, MCL1, BCL2L1, PIM1, MYC, CCND1, CCND2, CCND3, CDKN1A, AOX1, GFAP, STAM2, STAM, PTPN2, PTPN6, CREBBP, EP300, PIAS1, PIAS2, PIAS3, PIAS4, FHL1, PTPN11, GRB2, SOS1, SOS2, HRAS, RAF1, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MTOR
## 19                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    EGF, TGFA, FGF1, FGF2, FGF3, FGF4, FGF17, FGF6, FGF7, FGF8, FGF9, FGF10, FGF16, FGF5, FGF18, FGF20, FGF22, FGF19, FGF21, FGF23, NGF, BDNF, NTF3, NTF4, INS, IGF1, IGF2, PDGFA, PDGFB, PDGFC, PDGFD, CSF1, KITLG, FLT3LG, VEGFA, VEGFB, PGF, VEGFC, VEGFD, HGF, ANGPT1, ANGPT2, ANGPT4, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EGFR, FGFR1, FGFR2, FGFR3, FGFR4, NGFR, NTRK1, NTRK2, INSR, IGF1R, PDGFRA, PDGFRB, CSF1R, KIT, FLT3, FLT1, FLT4, KDR, MET, TEK, EPHA2, GRB2, GAB1, GAB2, SHC1, SHC2, SHC3, SHC4, PTPN11, SOS1, SOS2, PLCG1, PLCG2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, ZAP70, LAT, HTR7, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, PRKACA, PRKACB, PRKACG, RASGRF1, RASGRF2, GRIN1, GRIN2A, GRIN2B, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, HRAS, KRAS, NRAS, MRAS, RRAS, RRAS2, NF1, RASA1, RASA2, RASA3, RASA4, RASA4B, SYNGAP1, RASAL1, RASAL2, RASAL3, RASSF1, RASSF5, STK4, TIAM1, RAC1, RAC2, RAC3, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, BUB1B-PAK6, RHOA, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, IKBKG, CHUK, IKBKB, NFKB1, RELA, BAD, BCL2L1, FOXO4, FASLG, RALGAPA1, RALGAPA2, RALGAPB, RALGDS, RGL1, RGL2, RALA, RALB, PLD1, PLD2, EXOC2, TBK1, REL, MAPK8, MAPK10, MAPK9, RALBP1, CDC42, AFDN, SHOC2, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PLA1A, PLA2G10, PLA2G2D, PLA2G2E, PLA2G3, PLA2G2F, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G5, PLA2G2A, PLA2G2C, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PLA2G6, PLAAT3, PLAAT2, ELK1, ETS1, ETS2, BRAP, KSR1, KSR2, RAPGEF5, RAP1A, RAP1B, PLCE1, PRKCA, PRKCB, PRKCG, RIN1, ABL1, ABL2, RAB5A, RAB5B, RAB5C, ARF6
## 39  CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB, PRKCG, GNA12, GNG12, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RAPGEF2, NF1, RASA1, RASA2, RAP1A, RAP1B, EGF, TGFA, EREG, AREG, FGF1, FGF2, FGF3, FGF4, FGF17, FGF6, FGF7, FGF8, FGF9, FGF10, FGF16, FGF5, FGF18, FGF20, FGF22, FGF19, FGF21, FGF23, NGF, BDNF, NTF3, NTF4, INS, IGF1, IGF2, PDGFA, PDGFB, PDGFC, PDGFD, CSF1, KITLG, FLT3LG, VEGFA, VEGFB, PGF, VEGFC, VEGFD, HGF, ANGPT1, ANGPT2, ANGPT4, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EGFR, ERBB2, ERBB3, ERBB4, FGFR1, FGFR2, FGFR3, FGFR4, NGFR, NTRK1, NTRK2, INSR, IGF1R, PDGFRA, PDGFRB, CSF1R, KIT, FLT3, FLT1, FLT4, KDR, MET, TEK, EPHA2, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RRAS, RRAS2, MRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, LAMTOR3, MAPK1, MAPK3, MKNK1, MKNK2, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, ATF4, ELK1, ELK4, MYC, SRF, FOS, MAPT, STMN1, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, TNF, IL1A, IL1B, TGFB1, TGFB2, TGFB3, TNFRSF1A, IL1R1, IL1RAP, TGFBR1, TGFBR2, FASLG, FAS, CD14, RAC1, RAC2, RAC3, CDC42, TRADD, CASP3, TRAF2, DAXX, MYD88, IRAK1, IRAK4, TRAF6, GADD45A, GADD45B, GADD45G, TAB1, TAB2, ECSIT, MAP4K3, MAP4K4, MAP4K1, PAK1, PAK2, STK4, STK3, MAP4K2, MAP3K8, MAP3K1, MAP3K11, MAP3K2, MAP3K3, MAP3K13, MAP3K12, MAP3K20, MAP3K6, MAP3K5, MAP3K7, MAP3K4, TAOK2, TAOK3, TAOK1, MAP2K4, MAP2K7, MAP2K3, MAP2K6, MAPK8IP1, MAPK8IP2, MAPK8IP3, FLNA, FLNC, FLNB, CRK, CRKL, ARRB1, ARRB2, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK5, MAPKAPK2, MAPKAPK3, RPS6KA5, RPS6KA4, CDC25B, NFATC1, NFATC3, JUN, JUND, ATF2, TP53, DDIT3, MAX, MEF2C, HSPB1, AKT1, AKT2, AKT3, PPM1A, PTPRR, PTPN5, PTPN7, DUSP1, DUSP4, DUSP2, DUSP7, DUSP8, DUSP5, DUSP16, DUSP6, DUSP9, DUSP10, DUSP3, PPP5C, PPM1B, HSPA8, HSPA1A, HSPA2, HSPA1L, HSPA1B, HSPA6, MECOM, MAP2K5, MAPK7, NR4A1, MAP3K14, CHUK, IKBKB, IKBKG, NLK, NFKB1, NFKB2, RELA, RELB
## 58                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              RAP1A, RAP1B, MRAS, RAPGEF5, DOCK4, GRIN1, GRIN2A, GRIN2B, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, F2R, F2RL3, P2RY1, FPR1, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, ADORA2A, ADORA2B, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, RAPGEF3, RAPGEF4, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, RASGRP3, RASGRP2, EGF, FGF1, FGF2, FGF3, FGF4, FGF17, FGF6, FGF7, FGF8, FGF9, FGF10, FGF16, FGF5, FGF18, FGF20, FGF22, FGF19, FGF21, FGF23, NGF, INS, IGF1, PDGFA, PDGFB, PDGFC, PDGFD, CSF1, KITLG, VEGFA, VEGFB, PGF, VEGFC, VEGFD, HGF, ANGPT1, ANGPT2, ANGPT4, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EGFR, FGFR1, FGFR2, FGFR3, FGFR4, NGFR, INSR, IGF1R, PDGFRA, PDGFRB, CSF1R, KIT, FLT1, FLT4, KDR, MET, TEK, EPHA2, CRK, CRKL, RAPGEF1, BCAR1, CDH1, CTNNB1, MAGI1, MAGI2, MAGI3, RAPGEF2, RAPGEF6, LAT, FYB1, LCP2, SKAP1, PLCG1, PRKCA, PRKCB, PRKCG, PRKD1, PRKD3, PRKD2, DRD2, CNR1, GNAI1, GNAI3, GNAI2, GNAO1, RAP1GAP, SIPA1L1, SIPA1, SIPA1L2, SIPA1L3, ID1, THBS1, RALGDS, RALA, RALB, RAC1, RAC2, RAC3, APBB1IP, TLN1, TLN2, ITGA2B, ITGB3, PFN3, PFN1, PFN2, PFN4, VASP, ENAH, EVL, ACTG1, ACTB, ARAP3, RHOA, SRC, FARP2, CDC42, VAV3, VAV1, VAV2, TIAM1, PARD3, PARD6A, PARD6G, PARD6B, PRKCZ, PRKCI, AFDN, CTNND1, KRIT1, RGS14, RASSF5, ITGAL, ITGAM, ITGB2, ITGB1, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, PLCE1, HRAS, KRAS, NRAS, RRAS
## 20                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         INS, INSR, IGF1, IGF1R, IRS1, IRS2, IRS4, HRAS, KRAS, NRAS, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, CREB1, ATF2, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, ATF4, CREB5, ATF6B, EHMT2, EHMT1, FOXO1, FOXO3, SOD2, CAT, ATG5, KL, TSC1, TSC2, RHEB, MTOR, RPTOR, AKT1S1, ULK1, ATG13, RB1CC1, ATG101, RPS6KB1, RPS6KB2, EIF4EBP1, EIF4E, EIF4E2, EIF4E1B, ADIPOQ, ADIPOR1, ADIPOR2, APPL1, CAMKK2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, SIRT1, BAX, TP53, NFKB1, RELA, PPARG, PPARGC1A, STK11, SESN1, SESN3, SESN2, CAMK4
## 25                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        INS, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3C, PPP1R3D, PPP1R3B, PPP1R3E, INSR, IRS1, PTPN1, PTPN11, PTPRF, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MTOR, RPS6KB1, RPS6KB2, PRKCB, IL6, STAT3, SOCS3, GSK3B, GYS2, GYS1, TNF, TNFRSF1A, MAPK8, MAPK10, MAPK9, IKBKB, NFKBIA, NFKB1, RELA, NOS3, PRKCZ, TBC1D4, SLC2A4, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, ACACB, CPT1B, AGT, SLC27A1, SLC27A4, SLC27A2, SLC27A3, SLC27A5, SLC27A6, CD36, PRKCQ, PRKCD, PTPA, SREBF1, IRS2, TRIB3, PYGL, PYGM, PYGB, FOXO1, PCK1, PCK2, G6PC1, G6PC2, G6PC3, SLC2A2, NR1H3, NR1H2, PPARGC1B, MLX, MLXIP, MLXIPL, CPT1A, PRKCE, PPARGC1A, PPARA, PDPK1, PTEN, OGA, OGT, SLC2A1, GFPT2, GFPT1, CRTC2, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5
## 27                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         MAP3K7, STK11, CAB39, CAB39L, STRADA, STRADB, LEP, LEPR, CAMKK2, ADRA1A, ADIPOQ, ADIPOR1, ADIPOR2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, PFKFB1, PFKFB2, PFKFB3, PFKFB4, FBP1, FBP2, PFKM, PFKP, PFKL, HNF4A, G6PC1, G6PC2, G6PC3, PCK1, PCK2, CRTC2, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, PPARGC1A, ELAVL1, CCND1, CCNA2, CCNA1, EEF2K, EEF2, FOXO1, FOXO3, SIRT1, SLC2A4, GYS2, GYS1, LIPE, HMGCR, SREBF1, FASN, ACACA, SCD, SCD5, ACACB, MLYCD, CPT1A, CPT1B, CPT1C, CIDEA, PPP2CA, PPP2CB, PPP2R1B, PPP2R1A, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, PPP2R3B, PPP2R3C, PPP2R3A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, PPP2R5A, TBC1D1, RAB2A, RAB8A, RAB10, RAB11B, RAB14, CFTR, CD36, IGF1, IGF1R, INS, INSR, IRS1, IRS2, IRS4, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PDPK1, AKT1, AKT2, AKT3, TSC2, TSC1, RHEB, MTOR, RPTOR, AKT1S1, RPS6KB1, RPS6KB2, EIF4EBP1, PPARG, ULK1
## 29                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             AKT1, AKT2, AKT3, PDE3B, GCG, GCGR, GNAS, ADCY2, PRKACA, PRKACB, PRKACG, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, PPP4R3A, PPP4R3B, PPP4R3C, PPP4C, CRTC2, SIK2, CREBBP, EP300, PPARGC1A, SIK, SIK1, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, CAMK2A, CAMK2D, CAMK2B, CAMK2G, FOXO1, SIRT1, PPARA, PRMT1, G6PC1, G6PC2, G6PC3, PCK1, PCK2, CPT1A, CPT1B, CPT1C, GYS2, GYS1, PHKB, PHKA2, PHKA1, PHKG1, PHKG2, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PYGL, PYGM, PYGB, PFKFB1, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, ACACA, ACACB, SLC2A1, SLC2A2, GCK, FBP1, FBP2, PFKM, PFKP, PFKL, PGAM1, PGAM2, PGAM4, PKM, PDHA2, PDHA1, PDHB, LDHAL6A, LDHAL6B, LDHA, LDHB, LDHC
## 46                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               INS, INSR, IRS1, IRS2, IRS4, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, PDPK1, AKT1, AKT2, AKT3, GSK3B, GYS2, GYS1, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3C, PPP1R3D, PPP1R3B, PPP1R3E, PPP1R3F, PHKG1, PHKG2, PHKB, PHKA2, PHKA1, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PYGL, PYGM, PYGB, PDE3B, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR2A, PRKAR2B, PRKAR1B, LIPE, PRKCZ, PRKCI, SLC2A4, FLOT2, FLOT1, SH2B2, SORBS1, CBL, CBLB, CRK, CRKL, RAPGEF1, RHOQ, EXOC7, TRIP10, SREBF1, ACACA, ACACB, FASN, PKLR, HK3, HK1, HK2, HKDC1, GCK, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, FOXO1, PPARGC1A, G6PC1, G6PC2, G6PC3, FBP1, FBP2, PCK1, PCK2, MTOR, RPTOR, RPS6KB1, RPS6KB2, RPS6, EIF4EBP1, EIF4E, EIF4E2, EIF4E1B, TSC1, TSC2, RHEB, BAD, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, ELK1, SOCS1, SOCS2, SOCS3, SOCS4, PTPN1, PTPRF, MAPK8, MAPK10, MAPK9, IKBKB, INPPL1, INPP5A
## 47                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              INS, INSR, IGF1, IGF1R, IRS1, IRS2, IRS4, HRAS, KRAS, NRAS, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, FOXO1, FOXO3, SOD2, CAT, ATG5, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, MTOR, RPTOR, AKT1S1, RPS6KB1, RPS6KB2, SIRT1, SOD1, EIF4EBP2, HSPA8, HSPA1A, HSPA2, HSPA1L, HSPA1B, HSPA6, CRYAB, HDAC1, HDAC2, FOXA2, CLPB
## 61                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              C1QA, C1QB, C1QC, C2, C4A, C4B, C3, C3AR1, C5, C5AR1, LBP, CD14, LY96, TLR4, TIRAP, MYD88, IRAK4, IRAK1, TRAF6, TAB1, TAB2, MAP3K7, CHUK, IKBKB, IKBKG, NFKBIA, RELA, NFKB1, TNF, IL1B, IL6, IL12A, IL12B, CXCL8, TICAM1, TRAF3, IKBKE, TBK1, IRF3, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IL17A, IL17RA, IL17RC, CXCL1, CXCL2, CXCL3, FASLG, FAS, FADD, TNFRSF1A, TRADD, CASP8, CASP3, RIPK1, TAB3, SREBF1, FASN, ACACA, SCD, SCD5, LPIN1, LPIN3, LPIN2, MIR217, SIRT1, TRA2A, TRA2B, ADIPOQ, ADIPOR1, ADIPOR2, CAMKK2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, FOXO1, FOXO3, PPARGC1A, PPARA, CPT1A, ACADVL, ACADM, ACOX3, ACOX1, FABP1, ADH1A, ADH1B, ADH1C, ADH7, ADH4, ADH5, ADH6, ALDH2, ALDH3A2, ALDH1B1, ALDH7A1, ALDH9A1, CYP2E1, ACACB, MLYCD, CPT1B, CPT1C, NOX4, AKT1, AKT2, AKT3, GSK3B, CTNNB1, TCF7, TCF7L1, TCF7L2, LEF1, CCND1, MAP3K5, MAP2K4, MAP2K7, MAPK8, MAPK10, MAPK9, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, MAP3K14
## 71                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              TNF, TNFRSF1A, TRADD, TNFRSF1B, TRAF2, MTOR, MAPK8, MAPK10, MAPK9, CHUK, IKBKB, IKBKG, NFKBIA, NFKBIB, NFKBIE, NFKB1, RELA, SOCS3, IRS1, IRS2, IRS4, AKT1, AKT2, AKT3, CD36, ACSL6, ACSL4, ACSL1, ACSL5, ACSL3, ACSBG1, ACSBG2, PRKCQ, LEP, LEPR, JAK2, STAT3, POMC, AGRP, NPY, PPARGC1A, PCK1, PCK2, G6PC1, G6PC2, G6PC3, PTPN11, PPARA, RXRA, RXRB, RXRG, ADIPOQ, ADIPOR1, ADIPOR2, STK11, CAMKK2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, ACACB, CPT1A, CPT1B, CPT1C, SLC2A1, SLC2A4
## 22                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      SLC2A1, NRP1, MYC, TRRAP, KAT5, CCND2, ITGAL, ITGB2, ICAM1, HRAS, KRAS, NRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, CD4, TLN1, TLN2, RANBP3, RAN, XPO1, CALR, CANX, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, NFATC4, IL2RB, IL2RG, JAK1, JAK3, STAT5A, STAT5B, IL2, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G, HLA-E, B2M, FDPS, VDAC1, SLC25A4, SLC25A5, SLC25A6, SLC25A31, VDAC2, VDAC3, TSPO, VAC14, RANBP1, MAD1L1, MAD2L1, BUB1B, BUB3, ANAPC1, ANAPC2, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, ANAPC10, ANAPC11, CDC26, ANAPC13, ANAPC15, ANAPC16, CDC20, PTTG1, PTTG2, ESPL1, CCNB2, CDKN2B, CDKN2A, CDK4, CCND1, CCND3, CDKN1A, CCNA2, CCNA1, CCNE1, CCNE2, CDK2, RB1, E2F1, E2F2, E2F3, ATM, ATR, CHEK1, CHEK2, TP53, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, AKT1, AKT2, AKT3, DLG1, PTEN, TNF, TNFRSF1A, MAP3K1, MAP2K4, MAPK8, MAPK10, MAPK9, JUN, MMP7, IL1R1, IL1R2, CD3D, CD3E, CD3G, MAP3K3, CHUK, IKBKB, IKBKG, NFKBIA, NFKB1, RELA, GPS2, LTBR, CD40, TNFRSF13C, MAP3K14, RELB, NFKB2, ZFP36, IL2RA, IL15, IL15RA, IL6, CSF2, LTA, BCL2L1, XIAP, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD2, SMAD3, SMAD4, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, NFYB, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, SRF, ELK4, ELK1, SPI1, ETS1, ETS2, TBPL2, TBPL1, TBP, FOS, EGR1, FOSL1, EGR2, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, ATF2, ATF4, CREB5, ATF6B, CRTC1, CRTC2, CRTC3, CREBBP, EP300, KAT2B, KAT2A, TCF3, POLB, LCK, BAX, CDKN2C, TERT, MSX1, MSX2
## 65                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  SRC, HRAS, KRAS, NRAS, MAPK1, MAPK3, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, DDB1, YWHAZ, YWHAB, YWHAQ, YWHAE, YWHAH, YWHAG, JAK1, STAT3, STAT5A, STAT5B, CASP3, HPN, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, RELA, REL, NFKB2, NFKB1, TP53, CCNE1, CCNE2, CDK2, EGR2, EGR3, VDAC3, LTBR, SP100, HNRNPK, CDKN1A, DDX3X, EIF2AK2, PRKACA, PRKACB, PRKACG, H2BC15, H2BC9, H2BC14, H2BW1, H2BC1, H2BC18, H2BC17, H2BC3, H2BC8, H2BC13, H2BC4, H2BC5, H2BC6, H2BC10, H2BC21, H2BC11, H2BC12, H2BC26, H2BC7, H2BW2, H2BK1, H2BC12L, H4C16, H4C15, H4C9, H4C4, H4C6, H4C12, H4C11, H4C3, H4C8, H4C2, H4C5, H4C13, H4C14, H4C1, H4C7, BAX, GRB2, TRADD, CDK1, TBPL2, TBPL1, TBP, USP7, MDM2, RBPJL, RBPJ, SNW1, GTF2H1, GTF2H2, GTF2H2C_2, GTF2H2C, GTF2H3, GTF2H4, GTF2E1, GTF2E2, SND1, CREBBP, EP300, GTF2B, CCND1, CCND2, CCND3, CDK6, CCNA2, CCNA1, SKP2, MRPS18B, TRAF1, TRAF2, TRAF3, TRAF5, JAK3, LYN, SYK, ATP6V0D1, ATP6V0D2, UBE3A, DLG1, SCRIB, PXN, BAK1, IRF3, PSMC1, RB1, RBL1, RBL2, CDKN1B, UBR4, JUN, CHD4, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, HDAC10, HDAC11, PKM, IRF9, DNAJA3, KAT2B, KAT2A, GTF2A1L, GTF2A1, GTF2A2, SRF, IKBKG, NFKBIA, RASA2, CDC42, RAC1, RHOA, GSN, SCIN, ACTN1, ACTN4, CDK4, CDKN2A, CDKN2B, CHEK1, CDC20, MAD1L1, VAC14, RANBP1, POLB, IRF7, IL6ST, CCR5, CCR8, CCR3, CCR4, MAPKAPK2, CASP8, BAD, PMAIP1, C3, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G, HLA-E
## 26                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    CD36, SLC27A1, SLC27A4, SLC27A2, SLC27A5, SLC27A6, FABP1, FABP2, FABP3, FABP4, FABP5, FABP6, FABP7, PPARA, RXRA, RXRB, RXRG, PPARD, PPARG, HMGCS1, HMGCS2, APOA1, APOA2, APOC3, APOA5, PLTP, ME3, ME1, FADS2, SCD, SCD5, CYP7A1, CYP8B1, NR1H3, CYP27A1, DBI, LPL, ACSL6, ACSL4, ACSL1, ACSL5, ACSL3, ACSBG1, ACSBG2, OLR1, EHHADH, ACAA1, SCP2, ACOX3, ACOX1, ACOX2, CPT1A, CPT1B, CPT1C, CPT2, ACADL, ACADM, ANGPTL4, SORBS1, PLIN1, PLIN2, PLIN4, PLIN5, ADIPOQ, MMP1, UCP1, ILK, PDPK1, UBC, PCK1, PCK2, GK2, GK, AQP7, AQP7B
## 147                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    ACAT2, ACAT1, ACAA1, ACAA2, HADHB, HADH, HADHA, EHHADH, ECHS1, ACOX3, ACOX1, ACADS, ACADM, ACADL, ACADSB, ACADVL, GCDH, ACSL6, ACSL4, ACSL1, ACSL5, ACSL3, ACSBG1, ACSBG2, CPT1A, CPT1B, CPT1C, CPT2, ECI1, ECI2, CYP2U1, ADH1A, ADH1B, ADH1C, ADH7, ADH4, ADH5, ADH6, ALDH2, ALDH3A2, ALDH1B1, ALDH7A1, ALDH9A1
## 28                                                                                                                                                                                                                                                                                                                                                                           PODXL, PTPRC, RAB5A, RAB5B, RAB5C, PIK3C3, RAB7A, RAB7B, PLEKHM1, VPS11, VPS16, VPS18, VPS33A, VPS39, VPS41, RILP, DYNC1H1, DYNC2H1, DYNC1I1, DYNC1I2, DYNC1LI2, DYNC1LI1, DYNC2LI1, DYNLL1, DYNLL2, DYNLRB1, DYNLRB2, DYNLT1, DYNLT3, DCTN1, DCTN2, DCTN3, DCTN4, DCTN5, DCTN6, ACTR1A, ACTR1B, ACTR10, TUBA1B, TUBA4A, TUBA3C, TUBA1A, TUBA1C, TUBA8, TUBA3E, TUBA3D, TUBAL3, TUBB6, TUBB, TUBB1, TUBB2A, TUBB3, TUBB4A, TUBB8, TUBB2B, TUBB4B, FYCO1, ARL8A, ARL8B, PLEKHM2, KIF5A, KIF5B, KIF5C, KLC3, KLC1, KLC2, KLC4, ACBD3, RHOA, M6PR, RAB9A, RAB9B, GCC2, STX10, PFN3, PFN1, PFN2, PFN4, FLNA, FLNC, FLNB, EXOC7, EXOC5, EXOC4, EXOC2, RALA, ACTG1, ACTB, S100A10, ANXA2, AHNAK, AHNAK2, RHOJ, ARHGEF26, RHOG, ELMO1, ELMO2, ROCK2, MYL2, MYL5, MYL7, MYL9, MYL10, MYL12B, MYL12A, MYL11, FHOD1, CDC42, RAC1, NCKAP1, NCKAP1L, CYFIP1, CYFIP2, ABI1, BRK1, WASF3, ACTR2, ACTR3B, ACTR3C, ACTR3, ARPC1B, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, PAK1, PAK3, MYO6, PIK3CA, PIK3CD, PIK3CB, PIK3CG, PIK3C2G, PIK3C2A, PIK3C2B, CYTH3, CYTH4, CYTH2, CYTH1, ARF6, ARF1, SNX18, SNX33, SNX9, WASL, DNM2, TLR6, TLR2, TIRAP, MYD88, CD14, TLR4, LY96, TLR5, TLR9, IRAK1, IRAK4, TRAF6, MAP3K7, TAB1, TAB2, TAB3, IKBKG, CHUK, IKBKB, NFKBIA, NFKB1, RELA, NOD1, HSP90AA1, HSP90AB1, HSP90B1, RIPK2, CSE1L, KPNA1, KPNA3, KPNA4, RPS3, HRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, MAP2K4, MAP2K7, MAPK8, MAPK10, MAPK9, FOS, JUN, TNF, IL1B, IL6, CXCL8, CTNNB1, TCF7, TCF7L1, TCF7L2, LEF1, MYC, PKN1, FBXO22, SKP1, TNFRSF1A, TRAF2, TRADD, BIRC2, BIRC3, RIPK1, GAPDH, TNFSF10, TNFRSF10A, TNFRSF10B, FADD, CASP8, RIPK3, BAX, BAK1, CYCS, BCL2, CASP3, CASP7, RHOB, RHOH, RRAS, AKT1, AKT2, AKT3, MLKL, TXN, TXN2, NLRP3, NAIP, NLRC4, PYCARD, CASP1, IL18, CASP4, CASP5, GSDMD
## 49                                                                                                                                                                                                                                                                                                                                                                                                                        CD44, ITGA5, ITGB1, SRC, PTK2, CRK, CRKL, BCAR1, CTTN, HCLS1, PXN, ELMO1, ELMO2, DOCK1, RAC1, WASF1, WASF2, ACTR2, ACTR3B, ACTR3C, ACTR3, ARPC1B, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, ACTG1, ACTB, RHOA, DIAPH1, ROCK1, ROCK2, MYL2, MYL5, MYL7, MYL9, MYL10, MYL12B, MYL12A, MYL11, ACTN1, ACTN4, ILK, TLN1, TLN2, VCL, CDC42, WASL, PFN3, PFN1, PFN2, PFN4, EGFR, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, CYTH3, CYTH4, CYTH2, CYTH1, ARF6, ARF1, AKT1, AKT2, AKT3, FOXO1, FOXO3, FOXO4, FOXO6, GSK3A, GSK3B, RPS6KB1, RPS6KB2, MDM2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, ITPR1, ITPR2, ITPR3, CAST, CAPN1, CAPN2, CAPNS1, ATM, TP53, BCL2L1, BCL2, HK3, HK1, HK2, HKDC1, VDAC1, BAX, CYCS, BNIP3, PPID, CASP4, IL1B, IL18, TNF, TNFRSF1A, TRADD, TRAF2, TRAF5, RIPK1, MAP3K7, TAB1, TAB2, TAB3, IKBKG, CHUK, IKBKB, NFKBIA, NFKBIB, NFKB1, RELA, CXCL8, TIFA, IL1R1, CD14, TLR4, TLR5, TRAF6, PRKCD, PRKCE, PRKCQ, MALT1, BCL10, NOD1, ARHGEF2, RIPK2, MAPK8, MAPK10, MAPK9, JUN, UBE2V1, UBE2V2, UBE2NL, UBE2N, RBCK1, RNF31, SHARPIN, TNIP1, UBE2D4, UBE2D1, UBE2D2, UBE2D3, RBX1, CUL1, SKP1, BTRC, FBXW11, CGAS, STING1, MYD88, TBK1, IRF3, IFNB1, U2AF1, U2AF1L5, U2AF1L4, CCL5, CSF2, MAPK1, MAPK3, MAPK11, MAPK12, MAPK13, MAPK14, RPS6KA5, H3-5, H3-3B, H3C4, H3C3, H3C1, H3-3A, H3-4, H3C14, H3C15, H3C13, H3C6, H3C11, H3C8, H3C12, H3C10, H3C2, H3C7, CBX3, BECN1, BECN2, ATG14, PIK3R4, PIK3C3, RRAGA, RRAGB, RRAGC, RRAGD, MTOR, RPTOR, AKT1S1, ATG16L1, ATG5, ATG12, MAP1LC3C, MAP1LC3B, MAP1LC3A, MAP1LC3B2, C3, SQSTM1, CALCOCO2, UBA52, RPS27A, UBB, UBC, SEPTIN2, SEPTIN9, SEPTIN12, SEPTIN3, SEPTIN6, SEPTIN11, SEPTIN8, SEPTIN7, WIPI2, WIPI1, TECPR1, FNBP1, FNBP1L, GLMN, NLRP3, NAIP, NLRC4, PYCARD, CASP1
## 57                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 FN1, ITGA4, ITGA5, ITGB1, RHOG, SRC, PTK2, PTK2B, CRK, CRKL, BCAR1, ELMO1, ELMO2, DOCK1, IGH, FCGR2A, RAC1, RAC2, RAC3, PIP5K1C, PIP5K1A, PIP5K1B, ARF6, WASL, ACTR2, ACTR3B, ACTR3C, ACTR3, ARPC1B, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, ACTG1, ACTB, WIPF2, WIPF1, WIPF3, BAIAP2, WASF2, PXN, GIT2, ARHGEF7, CDC42, WAS, GNAQ, ARHGEF12, ARHGEF1, ARHGEF28, RHOA, ROCK1, ROCK2, FYB1, SKAP2, NLRP3, NLRC4, PKN1, PKN2, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, MEFV, LIMK1, PYCARD, CASP1, IL18, IL1B, TLR4, MYD88, IRAK4, IRAK1, TRAF6, TRAF2, TAB1, TAB2, MAP3K7, IKBKG, CHUK, IKBKB, NFKBIA, NFKB1, RELA, MAP2K1, MAP2K2, MAPK1, MAPK3, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, MAP2K4, MAP2K7, MAPK8, MAPK10, MAPK9, FOS, JUN, TICAM1, TBK1, IRF3, TNF, IL6, CXCL8, IFNB1, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, GSK3B, CCL2, CD4, CD8A, CD8B, CD8B2, LCK, ZAP70, LAT, LCP2, VAV3, VAV1, VAV2, PLCG1, NFATC1, NFATC2, NFATC3, IL2, IL10
## 74                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                IGH, SRC, FCGR2A, RAC1, CYTH3, CYTH4, CYTH2, CYTH1, ARF6, ARF1, NCKAP1, NCKAP1L, CYFIP1, CYFIP2, ABI1, BRK1, WASF1, WASF2, WASF3, ACTR2, ACTR3B, ACTR3C, ACTR3, ARPC1B, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, ACTG1, ACTB, ARHGEF1, RHOA, CDC42, MYO1H, MYO1B, MYO1F, MYO1A, MYO1C, MYO1D, MYO1E, MYO1G, MYO5A, MYO5B, MYO5C, MYO6, MYO10, MYH9, MYH10, MYH11, MYH14, WASL, NHERF1, EZR, F2, LPAR1, LPAR2, LPAR4, LPAR5, F2R, GNA12, GNA13, ARHGEF11, ARHGEF12, TUBA1B, TUBA4A, TUBA3C, TUBA1A, TUBA1C, TUBA8, TUBA3E, TUBA3D, TUBAL3, TUBB6, TUBB, TUBB1, TUBB2A, TUBB3, TUBB4A, TUBB8, TUBB2B, TUBB4B, ARHGEF2, ROCK1, ROCK2, FYN, ABL1, BAIAP2L1, BAIAP2, NCK1, NCK2, WIPF2, WIPF1, WIPF3, CTTN, HCLS1, NCL, ITGB1, IL1B, IL1R1, TLR4, TIRAP, MYD88, TLR5, IRAK1, IRAK4, PTPN6, PTPN11, TRAF6, TNF, TNFRSF1A, TRADD, GAPDH, TRAF2, RIPK1, MAP3K7, TAB1, TAB2, TAB3, IKBKG, CHUK, IKBKB, NFKBIA, NFKBIB, NFKB1, RELA, RPS3, MAPK1, MAPK3, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14, FOS, JUN, IL6, CXCL8, TNFSF10, TNFRSF10A, TNFRSF10B, FASLG, FAS, FADD, CASP8, TMBIM6, BAK1, BAX, CYCS, CASP9, CASP3, CASP7, ABCF2, NAIP, NLRP4, NLRP3, PYCARD, CASP1, CASP4, IL18, PAK1, PAK2, PAK3, RAB1A, SEC24B, SEC24A, SEC24C, SEC24D, TMED10, OCLN, CLDN4, CLDN3, CLDN7, CLDN19, CLDN16, CLDN14, CLDN15, CLDN17, CLDN20, CLDN11, CLDN18, CLDN22, CLDN5, CLDN10, CLDN8, CLDN6, CLDN2, CLDN1, CLDN9, CLDN23, CLDN34, CLDN25, CLDN24, TJP1
## 30                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   TNF, TNFRSF1A, BAG4, TRADD, TRAF2, TRAF5, RIPK1, BIRC2, BIRC3, MAP3K7, TAB1, TAB2, TAB3, MAP2K4, MAP2K7, MAPK8, MAPK10, MAPK9, JUN, FOS, ITCH, CFLAR, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, CEBPB, MAP3K5, MAP3K14, IKBKG, IKBKB, CHUK, NFKBIA, RELA, NFKB1, MAP3K8, MAP2K1, MAPK1, MAPK3, RPS6KA5, RPS6KA4, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, ATF2, ATF4, CREB5, ATF6B, RIPK3, MLKL, PGAM5, DNM1L, FADD, CASP8, CASP10, CASP7, CASP3, CCL2, CCL5, CCL20, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL10, CX3CL1, CSF1, CSF2, FAS, IL18R1, JAG1, IL1B, IL6, IL15, LIF, LTA, BCL3, SOCS3, TNFAIP3, TRAF1, JUNB, MMP3, MMP9, MMP14, EDN1, VEGFC, VEGFD, NOD2, ICAM1, SELE, VCAM1, PTGS2, TNFRSF1B, TRAF3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, DAB2IP, IRF1, IFNB1
## 31                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    CD4, BTRC, FBXW11, SKP1, CUL1, RBX1, CXCR4, CCR5, GNAI1, GNAI3, GNAI2, GNAO1, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PTK2, PTK2B, PXN, CRK, CRKL, AKT1, AKT2, AKT3, MTOR, RPS6KB1, RPS6KB2, NFKB1, RELA, FOS, JUN, BAD, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, GNAQ, GNA11, PLCG1, PLCG2, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, NFATC4, PRKCA, PRKCB, PRKCG, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, RAC1, RAC2, RAC3, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, BUB1B-PAK6, LIMK1, LIMK2, CFL1, CFL2, TNF, TNFRSF1B, BCL2L1, TLR2, TLR4, MYD88, IRAK4, IRAK1, TRAF6, TAB1, TAB2, MAP3K7, CHUK, IKBKB, IKBKG, NFKBIA, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, CGAS, STING1, TBK1, IRF3, APOBEC3H, APOBEC3F, APOBEC3A_B, APOBEC3D, APOBEC3A, APOBEC3C, APOBEC3G, APOBEC3B, SAMHD1, TRIM5, BST2, TNFRSF1A, RIPK1, TRADD, TRAF5, TRAF2, MAP2K3, MAP2K6, MAP2K7, FASLG, FAS, FADD, CASP8, BID, BAX, BAK1, BCL2, CYCS, CASP9, CASP3, CD3E, CD3G, CD3D, CD247, TAP1, TAP2, TAPBP, PDIA3, CALR, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G, HLA-E, AP1B1, AP1G1, AP1G2, AP1M1, AP1M2, AP1S1, AP1S2, AP1S3, B2M, ELOB, ELOC, CUL5, RNF7, DCAF1, DDB1, CUL4B, CUL4A, ATM, ATR, CHEK1, CDC25C, WEE1, WEE2, CCNB1, CCNB2, CCNB3, CDK1
## 37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         PDGFRA, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, TSC1, TSC2, RHEB, MTOR, EIF4EBP1, RPS6KB1, RPS6KB2, CHUK, IKBKB, IKBKG, NFKB1, RELA, EGFR, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, ELK1, SP1, ITGAV, ITGB3, SRC, RAC1, RAC2, RAC3, RHOA, CGAS, STING1, TBK1, IRF3, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, TNF, TNFRSF1A, RIPK1, TRADD, TRAF5, TRAF2, IL1B, IL1R1, NFKBIA, CCL2, CCL5, CXCL8, IL6, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, NFATC4, PTGS2, GNAI1, GNAI3, GNAI2, GNAO1, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, CCL3, CCL3L1, CCL3L3, CCL4, CCL4L2, CCL4L1, CX3CL1, GNA12, GNA13, ARHGEF1, ARHGEF11, ARHGEF12, AKAP13, ROCK1, ROCK2, CTNNB1, PTGER1, PTGER2, PTGER3, PTGER4, GNAS, GSK3B, CCND1, MYC, IL6R, JAK1, STAT3, VEGFA, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, CXCL12, CXCR4, PRKCA, PRKCB, PRKCG, PTK2B, PTK2, BCAR1, CRK, CRKL, PXN, IL10RA, IL10RB, CXCR2, CCR1, CCR3, CCR5, TAP1, TAP2, TAPBP, PDIA3, CALR, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G, HLA-E, B2M, CDKN2A, MDM2, TP53, CDKN1A, CDK4, CDK6, RB1, E2F1, E2F2, E2F3, FASLG, FAS, FADD, CASP8, BID, BAX, BAK1, CYCS, CASP9, CASP3
## 45                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                CSF1, CSF1R, GRB2, MAPK1, MAPK3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, IFNG, IFNGR1, IFNGR2, STAT1, IL1A, IL1B, IL1R1, TNF, TNFRSF1A, TGFB1, TGFB2, TGFBR1, TGFBR2, TNFSF11, TNFRSF11A, TNFRSF11B, TRAF2, TRAF6, LCK, FYN, MAP3K14, CHUK, RELB, NFKB2, MAP3K7, TAB1, TAB2, IKBKG, IKBKB, NFKBIA, RELA, NFKB1, NFATC2, NFATC1, IFNB1, MAP2K1, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, MAP2K7, MAPK8, MAPK10, MAPK9, FOS, FOSB, FOSL2, FOSL1, JUN, JUND, JUNB, RAC1, NOX1, CYBA, NCF2, NCF1, NCF4, BTK, TEC, OSCAR, LILRB2, LILRB1, LILRB5, LILRB4, LILRA1, LILRB3, LILRA3, LILRA2, LILRA4, LILRA6, LILRA5, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCGR3B, TREM2, SIRPA, SIRPG, SIRPB1, TYROBP, SYK, BLNK, LCP2, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, CAMK4, CREB1, SPI1, MITF, CTSK, ACP5, CALCR, ITGB3, PPARG, IFNAR1, IFNAR2, JAK1, TYK2, STAT2, IRF9, SOCS1, SOCS3, GAB2, FHL2, CYLD, SQSTM1
## 52                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   APOB, APOA4, APOA1, LDLR, OLR1, ARHGEF1, MMP1, RHOA, ROCK2, NOS3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, BAX, BAD, BCL2L1, BCL2, MAPK8, MAPK10, MAPK9, SOD2, PRKCA, POU2F1, POU2F2, POU2F3, CD40, CD40LG, CYP1A1, CYP2A6, CYP2A7, CYP2B6, CYP2C8, CYP2C9, CYP2J2, AGER, NOX1, CYBB, NCF1, CYBA, NCF2, NCF4, RAC1, SRC, JAK2, STAT3, CDC42, MAP2K4, MAP2K7, FOS, JUN, CCL2, ICAM1, CXCL8, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, HRAS, KRAS, NRAS, MAPK1, MAPK3, RELA, NFKB1, SELE, SELP, VCAM1, MMP3, MMP9, FAS, IL1B, IL6, TNF, HSPD1, HSPA8, HSPA1A, HSPA2, HSPA1L, HSPA1B, HSPA6, HSPA4, HSP90AA1, HSP90AB1, HSP90B1, TLR2, LBP, CD14, LY96, TLR4, TIRAP, MYD88, IRAK4, IRAK1, TRAF6, TAB1, TAB2, MAP3K7, CHUK, IKBKB, IKBKG, NFKBIA, TICAM2, TICAM1, TRAF3, MIB1, MIB2, TANK, IKBKE, TBK1, IRF7, IRF3, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, CD36, PPARG, RXRA, RXRB, RXRG, LYN, PTK2, VAV3, VAV1, VAV2, TLR6, RAP1A, RAP1B, CCL5, CCL3, CCL3L1, CCL3L3, CXCL1, CXCL2, CXCL3, IL12A, IL12B, NLRP3, IL18, HSPA5, ATF6, DDIT3, ERO1A, ITPR1, CAMK2A, CAMK2D, CAMK2B, CAMK2G, EIF2AK3, EIF2S1, ATF4, ERN1, TRAF2, MAP3K5, XBP1, ABCA1, ABCG1, NFE2L2, PYCARD, CASP1, VLDLR, PDPK1, GSK3B, NFATC1, NFATC2, NFATC3, PLCB1, PLCB2, PLCB3, PLCB4, PLCG1, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, TNFSF10, TNFRSF10A, TNFRSF10B, TNFRSF1A, FASLG, CASP8, BID, CYCS, APAF1, CASP9, CASP6, CASP3, CASP7, TP53
## 73                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              C3, TLR3, TICAM1, TRAF3, IKBKE, TBK1, IRF7, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IRF3, CREBBP, EP300, IFNB1, IFNAR1, IFNAR2, JAK1, TYK2, STAT1, STAT2, IRF9, EIF2AK2, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAP2K6, ZFP36, IL6, CSF2, CCR3, CCR5, CCR1, CCR4, CCR8, FAS, FADD, CASP8, BID, BAX, BAK1, CYCS, CASP9, CASP3, TNFRSF1A, TRADD, TRAF2, CHUK, IKBKB, IKBKG, NFKBIA, NFKB1, RELA, TP53, CDKN1A, CDK4, CDK6, RB1, E2F1, E2F2, E2F3, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G, HLA-E, IFNGR1, ICAM1, CD86, MICB, MICA, CLEC2B, UBA52, RPS27A, UBB, UBC, BECN1, BECN2, ATG14, PIK3C3, ATG3, MAP1LC3C, MAP1LC3B, MAP1LC3A, MAP1LC3B2, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, HIF1A, JUN, FOS, PIK3CG, PIK3R5, PIK3R6, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MTOR, PREX1, RAC1, MAPK8, MAPK10, MAPK9, CD200R1L, CD200R1, SYK, SRC, HCK, LYN, MAP2K4, MAP2K7, PLCG2, PLCG1, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, NFATC4, CXCL8, PTGS2, CXCL1, CXCL2, CXCL3, RCAN1, FGF2, VEGFA, PDGFB, ANGPT2, IL6ST, JAK2, STAT3, GSK3B, CTNNB1, TCF7, TCF7L1, TCF7L2, LEF1, CREB1, CCND1, MYC
## 85                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               TNFSF10, TNFRSF10A, TNFRSF10B, FASLG, FAS, FADD, TNF, TNFRSF1A, TRADD, CFLAR, CASP8, CASP10, CASP6, CASP3, CASP7, BID, BAX, BAK1, DIABLO, SEPTIN4, HTRA2, CYCS, APAF1, CASP9, PRF1, GZMB, TUBA1B, TUBA4A, TUBA3C, TUBA1A, TUBA1C, TUBA8, TUBA3E, TUBA3D, TUBAL3, MCL1, ACTG1, ACTB, SPTA1, SPTAN1, LMNA, LMNB1, LMNB2, PARP1, PARP2, PARP3, PARP4, DFFA, DFFB, ENDOG, AIFM1, ERN1, TRAF2, ITPR1, ITPR2, ITPR3, CAPN1, CAPN2, CASP12, EIF2AK3, EIF2S1, ATF4, DDIT3, CTSB, CTSC, CTSD, CTSF, CTSH, CTSK, CTSL, CTSO, CTSS, CTSV, CTSW, CTSZ, BIRC2, BIRC3, XIAP, BIRC5, BCL2L11, BCL2L1, BCL2, DAXX, RIPK1, DAB2IP, MAP3K5, MAPK8, MAPK10, MAPK9, BAD, JUN, FOS, TP53, HRK, MAP3K14, CHUK, IKBKB, IKBKG, NFKBIA, NFKB1, RELA, PTPN13, GADD45A, GADD45B, GADD45G, TRAF1, BCL2A1, ATM, PIDD1, TP53AIP1, BBC3, PMAIP1, CASP2, NGF, NTRK1, IL3, IL3RA, CSF2RB, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PDPK1, AKT1, AKT2, AKT3, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3
## 32                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         LCK, ZAP70, LAT, PLCG1, PRKCQ, IGH, SYK, LYN, BLNK, BTK, PLCG2, PRKCB, CARD10, CARD11, CARD14, BCL10, MALT1, IL1B, IL1R1, MYD88, IRAK1, IRAK4, TRAF6, TNF, TNFRSF1A, RIPK1, TRADD, TRAF2, TRAF5, BIRC2, BIRC3, EDA, EDAR, EDARADD, CYLD, EDA2R, RIGI, TRIM25, LBP, CD14, TLR4, LY96, TIRAP, TICAM2, TICAM1, CD40LG, CD40, TRAF3, TNFSF11, TNFRSF11A, LTA, LTB, TNFSF14, LTBR, MAP3K14, MAP3K7, TAB1, TAB2, TAB3, TNFSF13B, TNFRSF13C, IKBKG, CHUK, IKBKB, PARP1, PIAS4, UBE2I, ATM, PIDD1, ERC1, NFKBIA, NFKB1, RELA, CFLAR, XIAP, BCL2L1, BCL2, GADD45A, GADD45B, GADD45G, TRAF1, BCL2A1, NFKB2, CXCL8, TNFAIP3, PTGS2, CCL4, CCL4L2, CCL4L1, CXCL1, CXCL2, CXCL3, VCAM1, PLAU, CSNK2A1, CSNK2A2, CSNK2A3, CSNK2B, RELB, CCL13, CCL19, CCL21, CXCL12, ICAM1
## 33                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                TH, DDC, SLC18A1, SLC18A2, DRD1, DRD5, CALY, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB, PRKCG, FOS, GNAS, GNAL, ADCY5, PRKACA, PRKACB, PRKACG, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, PPP1R1B, PPP1CA, PPP1CB, PPP1CC, SCN1A, CACNA1C, CACNA1D, CACNA1A, CACNA1B, KCNJ3, KCNJ6, KCNJ9, KCNJ5, DRD3, DRD4, GNAI1, GNAI3, GNAI2, GNAO1, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, DRD2, ARRB1, ARRB2, PPP2CA, PPP2CB, PPP2R1B, PPP2R1A, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, PPP2R3B, PPP2R3C, PPP2R3A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, PPP2R5A, AKT1, AKT2, AKT3, GSK3A, GSK3B, GRIN2A, GRIN2B, GRIA1, GRIA2, GRIA3, GRIA4, KIF5A, KIF5B, KIF5C, CLOCK, BMAL1, SLC6A3, MAOB, MAOA, COMT, LRTOMT
## 55                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        RLN1, RLN2, RXFP1, GNAO1, GNAI1, GNAI3, GNAI2, GNAS, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, ADCY5, PRKACA, PRKACB, PRKACG, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, VEGFA, VEGFB, VEGFC, VEGFD, NFKBIA, NFKB1, RELA, NOS2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PRKCZ, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, MMP2, MMP9, AKT1, AKT2, AKT3, NOS3, NOS1, EDN1, EDNRB, MMP1, MMP13, TGFB1, TGFBR1, TGFBR2, SMAD2, ACTA2, COL1A1, COL1A2, COL3A1, COL4A2, COL4A4, COL4A6, COL4A1, COL4A5, COL4A3, INSL3, RXFP2, RLN3, RXFP3, ADCY1, ADCY2, ADCY3, ADCY4, ADCY6, ADCY7, ADCY8, ADCY9, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, MAP2K4, MAP2K7, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, JUN, FOS, HRAS, KRAS, NRAS, SRC, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, ARRB1, ARRB2, EGFR, GRB2, INSL5, RXFP4, GNA15
## 56                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               TSHB, CGA, TSHR, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, PRKCB, PRKCG, TTF1, TTF2, PAX8, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, TG, HSPA5, HSP90B1, CANX, PDIA4, ASGR1, ASGR2, ITPR1, ITPR2, ITPR3, SLC5A5, SLC26A4, TPO, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, FXYD2, IYD, DUOXA2, DUOX1, DUOX2, GPX6, GPX7, GPX2, GPX3, GPX1, GPX5, GPX8, GSR, ALB, TTR, SERPINA7, LRP2
## 60                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          ADRB1, ADRB2, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, FXYD2, SLC9A1, KCNQ1, KCNE1, KCNE1B, ATP2B1, ATP2B3, ATP2B4, ATP2B2, SLC8A1, SLC8A2, SLC8A3, SCN5A, SCN7A, SCN1B, SCN4B, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CACNB1, CACNB2, CACNB3, CACNB4, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, RYR2, PPP2CA, PPP2CB, PPP2R1B, PPP2R1A, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, PPP2R3B, PPP2R3C, PPP2R3A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, PPP2R5A, PPP1CA, PPP1CB, PPP1CC, TNNC1, TNNI3, TNNT2, TPM1, TPM2, TPM3, TPM4, ACTC1, MYH7, MYH6, MYL2, MYL3, MYL4, PLN, ATP2A1, ATP2A3, ATP2A2, AGT, AGTR1, AGTR2, ADRA1A, ADRA1B, ADRA1D, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, PPP1R1A, MAPK1, MAPK3, RPS6KA5, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, CREM, BCL2, RAPGEF3, RAPGEF4, MAPK11, MAPK12, MAPK13, MAPK14, GNAI1, GNAI3, GNAI2, PIK3CG, PIK3R5, PIK3R6, AKT1, AKT2, AKT3
## 64                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GHRH, GHRHR, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADCY10, SST, SSTR1, SSTR2, SSTR3, SSTR5, GNAI1, GNAI3, GNAI2, PRKACA, PRKACB, PRKACG, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, CREBBP, EP300, POU1F1, FOS, GH1, GH2, CSH1, CSH2, GHRL, GHSR, MRAP2, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, PRKCB, PRKCG, ITPR1, ITPR2, ITPR3, CACNA1S, CACNA1C, CACNA1D, CACNA1F, GHR, JAK2, PLCG1, PLCG2, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, STAT1, STAT3, STAT5A, STAT5B, IRS1, IRS2, IRS4, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, AKT1, AKT2, AKT3, MTOR, GSK3B, IGF1, JUNB, SOCS1, SOCS2, SOCS3, IGFALS, IGFBP3, PTK2, BCAR1, CRK, CRKL, MAP3K1, MAP2K3, MAP2K4, MAP2K6, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14
## 68                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             SLC2A1, SLC2A2, GCK, TRPM4, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ABCC8, KCNJ11, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CAMK2A, CAMK2D, CAMK2B, CAMK2G, KCNMA1, KCNU1, KCNMB1, KCNMB2, KCNMB3, KCNMB4, KCNN1, KCNN2, KCNN3, KCNN4, GCG, GLP1R, GIP, GPR119, ADCYAP1, ADCYAP1R1, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, PDX1, INS, RAPGEF4, RIMS2, PCLO, RAB3A, CCK, CCKAR, CHRM3, FFAR1, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, ITPR3, RYR2, VAMP2, STX1A, SNAP25, PRKCA, PRKCB, PRKCG
## 76                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          CHAT, ACHE, SLC18A3, CHRM1, CHRM3, CHRM5, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, PRKCA, PRKCB, PRKCG, KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5, KCNJ2, KCNJ12, KCNJ18, KCNJ4, KCNJ14, CHRM2, CHRM4, GNAI1, GNAI3, GNAI2, GNAO1, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, KCNJ3, KCNJ6, PIK3CG, PIK3R5, PIK3R6, HRAS, KRAS, NRAS, MAP2K1, MAPK1, MAPK3, FOS, CHRNA7, CHRNA4, CHRNB2, CHRNA3, CHRNB4, CHRNA6, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, CREB1, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, CAMK2A, CAMK2D, CAMK2B, CAMK2G, CAMK4, JAK2, FYN, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, BCL2, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S, SLC5A7
## 82                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               AGT, AGTR1, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, PRKCA, PRKCB, PRKCG, PRKCE, PRKD1, PRKD3, PRKD2, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, ATF1, DAGLA, DAGLB, KCNK3, KCNK9, KCNJ5, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, CACNA1G, CACNA1H, CACNA1I, CACNA1C, CACNA1D, CACNA1F, CACNA1S, ORAI1, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK1D, CAMK1G, CAMK1, CAMK2A, CAMK2D, CAMK2B, CAMK2G, CAMK4, ATP2B1, ATP2B3, ATP2B4, ATP2B2, LIPE, LDLR, SCARB1, POMC, MC2R, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, CYP11B2, STAR, NR4A2, NR4A1, CYP11A1, HSD3B1, HSD3B2, CYP21A2, NPPA, NPR1, PDE2A
## 95                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     CASR, GNAI1, GNAI3, GNAI2, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, GCM1, GCM2, MAFB, GATA3, SP1, VDR, RXRA, RXRB, RXRG, FGF23, FGFR1, KL, MAPK1, MAPK3, EGR1, PTH, PTHLH, PTH1R, ARRB1, ARRB2, ARAF, BRAF, RAF1, MAP2K1, PRKCA, PRKCB, PRKCG, TRPV5, SLC34A1, SLC34A2, SLC34A3, NHERF1, GNAS, PDE4A, PDE4B, PDE4C, PDE4D, PRKACA, PRKACB, PRKACG, CYP27B1, CYP24A1, MEF2A, MEF2C, MEF2D, SOST, NR4A2, NACA, JUND, BGLAP, LRP5, LRP6, CREB1, ATF2, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, ATF4, CREB5, ATF6B, TNFSF11, BCL2, CDKN1A, FOS, RUNX2, MMP13, GNA12, GNA13, ARHGEF1, ARHGEF11, AKAP13, RHOA, PLD1, PLD2, MMP14, MMP15, MMP16, MMP17, MMP24, MMP25, HBEGF, EGFR
## 101                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           ESR1, ESR2, HSP90AA1, HSP90AB1, HSP90B1, FKBP4, FKBP5, HSPA8, HSPA1A, HSPA2, HSPA1L, HSPA1B, HSPA6, NCOA1, NCOA2, NCOA3, BCL2, EBAG9, KRT9, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT40, KRT39, KRT23, KRT25, KRT28, KRT24, KRT27, KRT20, KRT38, KRT37, KRT36, KRT26, CTSD, TFF1, PGR, TGFA, RARA, FOS, JUN, SP1, GPER1, GNAS, SRC, MMP2, MMP9, HBEGF, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, EGFR, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, GABBR1, GABBR2, GNAI1, GNAI3, GNAI2, GNAO1, KCNJ3, KCNJ6, KCNJ9, KCNJ5, POMC, OPRM1, PRKCD, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, NOS3, GRM1
## 111                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         POMC, MC2R, MRAP, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PDE8B, PDE8A, PRKACA, PRKACB, PRKACG, NR0B1, NR5A1, NR4A1, SP1, PBX1, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, CYP11B1, CYP17A1, STAR, NCEH1, AGT, AGTR1, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, KCNK2, CACNA1G, CACNA1H, CACNA1I, CACNA1C, CACNA1D, CACNA1F, CACNA1S, ORAI1, KCNA4, KCNK3, LDLR, SCARB1, CYP11A1, HSD3B1, HSD3B2, CYP21A2
## 121                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             KISS1, KISS1R, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, PRKCB, PRKCG, ITPR1, ITPR2, ITPR3, HCN1, HCN2, HCN3, CACNA1G, CACNA1H, CACNA1I, TRPC1, TRPC4, TRPC5, KCNJ11, KCNJ3, KCNJ6, KCNJ9, KCNJ5, GABBR1, GABBR2, KCNN1, KCNN2, KCNN3, KCNN4, CACNA1S, CACNA1C, CACNA1D, CACNA1F, ARRB1, ARRB2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, AKT1, AKT2, AKT3, GNRH1, GNRH2, ESR2, GPER1, LHB, SPP1, CGA
## 133                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      AGTR1, EDNRA, EDNRB, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, GNAQ, GNA11, GNA12, GNA13, TRPC6, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, MEF2A, BORCS8-MEF2B, MEF2B, MEF2C, MEF2D, NFATC1, NFATC2, NFATC3, NFATC4, SRF, GATA4, MYH7, MYH6, NPPB, NPPA, NPR1, NPPC, NPR2, PRKG1, PRKG2, CACNA1C, CACNA1D, CACNA1F, CACNA1S, KCNMA1, KCNU1, KCNMB1, KCNMB2, KCNMB3, KCNMB4, SLC8A1, SLC8A2, SLC8A3, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ATP2B1, ATP2B3, ATP2B4, ATP2B2, RGS2, GTF2IRD1, GTF2I, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, IRAG1, PLN, ATP2A1, ATP2A3, ATP2A2, RHOA, ROCK1, ROCK2, PPP1R12A, PPP1CA, PPP1CB, PPP1CC, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, MYLK, MYLK2, MYLK3, MYLK4, MYL9, CNGA1, CNGB1, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PDE2A, PDE3A, PDE3B, PDE5A, GUCY1A2, GUCY1A1, GUCY1B1, KNG1, BDKRB2, OPRD1, ADORA1, ADORA3, GNAI1, GNAI3, GNAI2, INS, INSR, IRS1, IRS2, IRS4, PIK3CG, PIK3R5, PIK3R6, AKT1, AKT2, AKT3, NOS3, ADRB1, ADRB2, ADRB3, PRKCE, KCNJ8, VDAC1, VDAC2, VDAC3, SLC25A4, SLC25A5, SLC25A6, SLC25A31, PPIF, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, BAD, VASP, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3
## 34                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          LDLR, SCARB1, CD81, CLDN4, CLDN3, CLDN7, CLDN19, CLDN16, CLDN14, CLDN15, CLDN17, CLDN20, CLDN11, CLDN18, CLDN22, CLDN5, CLDN10, CLDN8, CLDN6, CLDN2, CLDN1, CLDN9, CLDN23, CLDN34, CLDN25, CLDN24, OCLN, OAS1, OAS2, OAS3, RNASEL, RIGI, MAVS, TRAF3, TBK1, IKBKE, IRF3, IRF7, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNG, TLR3, TICAM1, TRAF6, RIPK1, CHUK, IKBKB, IKBKG, NFKBIA, NFKB1, RELA, TNF, CXCL10, EIF2AK1, EIF2AK2, EIF2AK3, EIF2AK4, IFIT1, IFIT1B, EIF3E, EIF2S1, STAT3, SOCS3, IFNAR1, IFNAR2, JAK1, TYK2, STAT1, STAT2, IRF9, MX1, MX2, RSAD2, PPP2R1B, PPP2R1A, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, PPP2CA, PPP2CB, PIAS1, EGF, EGFR, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, BRAF, RAF1, ARAF, YWHAZ, YWHAB, YWHAQ, YWHAE, YWHAH, YWHAG, MAP2K1, MAP2K2, MAPK1, MAPK3, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, AKT1, AKT2, AKT3, GSK3B, CTNNB1, BAD, CDKN1A, TP53, CDK2, CDK4, CDK6, RB1, E2F1, E2F2, E2F3, TNFRSF1A, TRADD, TRAF2, FASLG, FAS, FADD, CASP8, CASP3, CFLAR, BID, BAX, BAK1, CYCS, APAF1, CASP9, PSME3, RXRA, PPARA, NR1H3, CCND1, MYC
## 40                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       HSPG2, SLC10A1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD3, CDKN1A, MAPK8, MAPK10, MAPK9, MYC, EGR2, EGR3, CREBBP, EP300, FASLG, DDB1, DDB2, MAP3K1, YWHAZ, YWHAB, YWHAQ, MAP2K4, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, CHUK, IKBKB, IKBKG, NFKBIA, NFKB1, RELA, MMP9, BCL2, BAD, FAS, FADD, CASP8, CASP10, BID, BAX, APAF1, CYCS, CASP9, CASP3, CASP12, BIRC5, TP53, CCNA2, CCNA1, CDK2, CCNE1, CCNE2, RB1, E2F1, E2F2, E2F3, ATP6AP1, PRKCA, PRKCB, PRKCG, NFATC1, NFATC2, NFATC3, NFATC4, TNF, JAK1, JAK2, JAK3, TYK2, STAT3, STAT1, STAT2, STAT4, STAT5A, STAT5B, STAT6, VDAC3, PTK2B, SRC, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, JUN, SMAD4, ATF2, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, ATF4, CREB5, ATF6B, CXCL8, PCNA, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, FOS, ELK1, TLR2, MYD88, TIRAP, TLR4, IRAK4, IRAK1, TRAF6, TAB1, TAB2, MAP3K7, IL6, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, MAP2K7, TICAM2, TLR3, TICAM1, RIGI, IFIH1, MAVS, TRAF3, IKBKE, TBK1, DDX3X, IRF3, IRF7, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNAR1
## 42                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           CD46, MSN, SLAMF1, CLEC4M, CD209, RIGI, IFIH1, MAVS, TRAF3, IKBKE, TBK1, IRF3, CHUK, IKBKB, IKBKG, NFKBIB, NFKBIA, NFKB1, RELA, TLR7, TLR9, MYD88, IRAK1, IRAK4, IRF7, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, TLR2, TLR4, TRAF6, CSNK2A1, CSNK2A2, CSNK2A3, CSNK2B, TNFAIP3, MAP3K7, TAB2, MAPK8, MAPK10, MAPK9, JUN, FOS, IL1A, IL1B, IL6, IL12A, IL12B, IFNAR1, IFNAR2, RACK1, JAK1, TYK2, STAT1, STAT2, IRF9, OAS1, OAS2, OAS3, ADAR, MX1, MX2, EIF2AK1, EIF2AK2, EIF2AK3, EIF2AK4, RAB9A, RAB9B, HSPA8, HSPA1A, HSPA2, HSPA1L, HSPA1B, HSPA6, EIF3H, EIF2S1, RCHY1, TP53, TP73, BBC3, FASLG, FAS, TRADD, FADD, CASP8, BID, BAX, BAK1, BCL2, BCL2L1, BAD, CYCS, APAF1, CASP9, CASP3, CDKN1B, CCND1, CCND2, CCND3, CCNE1, CCNE2, CDK4, CDK6, CDK2, CD3D, CD3E, CD3G, CD28, IL2, IL2RA, IL2RB, IL2RG, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, CBLB, AKT1, AKT2, AKT3, GSK3B, JAK3, STAT3, STAT5A, STAT5B, FCGR2B
## 43                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            CR2, CD19, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, TLR2, MYD88, IRAK4, IRAK1, TRAF6, TAB1, TAB2, MAP3K7, CHUK, IKBKB, IKBKG, NFKBIA, NFKB1, RELA, TNF, IL6, RIGI, MAVS, TRAF3, TBK1, IKBKE, IRF7, IRF3, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNAR1, IFNAR2, JAK1, TYK2, STAT1, STAT2, IRF9, EIF2AK2, OAS1, OAS2, OAS3, CXCL10, ISG15, FAS, FADD, CASP8, BID, BCL2L11, BCL2, BAX, BAK1, CYCS, APAF1, CASP9, CASP3, CD3E, CD3G, CD3D, CD247, PSMC2, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD2, PSMD1, PSMD3, PSMD12, PSMD11, PSMD6, PSMD7, PSMD13, PSMD4, PSMD14, PSMD8, ADRM1, SEM1, TAP1, TAP2, TAPBP, PDIA3, CALR, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G, HLA-E, B2M, SNW1, SIN3A, HDAC1, HDAC2, NCOR2, SAP30, SAP30L, CIR1, RBPJL, RBPJ, HES1, FCER2, RUNX3, MYC, USP7, MDM2, TP53, CDKN1A, GADD45A, GADD45B, GADD45G, DDB2, POLK, TRAF5, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MAP3K14, RELB, NFKB2, TRADD, NFKBIB, NFKBIE, MAP2K4, MAP2K7, MAPK8, MAPK10, MAPK9, TRAF2, RIPK1, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, JUN, ENTPD3, ENTPD8, ENTPD1, CD40, CD44, ITGAL, CD58, ICAM1, VIM, TNFAIP3, JAK3, STAT3, LYN, SYK, NEDD4, RAC1, IGH, BTK, BLNK, PLCG2, SKP2, CDKN1B, CCND1, CCND2, CCND3, CDK4, CDK6, CCNA2, CCNA1, CCNE1, CCNE2, CDK2, RB1, E2F1, E2F2, E2F3
## 53                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                FHIT, RARB, RXRA, RXRB, RXRG, TP53, CDKN1A, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK, BCL2, CYCS, APAF1, CASP9, CASP3, MYC, MAX, ZBTB17, CDKN2B, CDK4, CDK6, CCND1, CKS1B, CKS2, SKP2, CDKN1B, CDK2, CCNE1, CCNE2, RB1, E2F1, E2F2, E2F3, COL4A2, COL4A4, COL4A6, COL4A1, COL4A5, COL4A3, LAMA1, LAMA2, LAMA3, LAMA5, LAMA4, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, FN1, ITGA2, ITGA2B, ITGA3, ITGA6, ITGAV, ITGB1, PTK2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PTEN, AKT1, AKT2, AKT3, CHUK, IKBKB, IKBKG, NFKBIA, NFKB1, RELA, BIRC2, BIRC3, XIAP, BIRC7, BCL2L1, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, PTGS2, NOS2
## 135                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               TPSD1, TPSAB1, TPSB2, PLG, PRSS3, PRSS2, PRSS1, TMPRSS2, TMPRSS4, TMPRSS11D, PRKCB, OAS1, OAS2, OAS3, RNASEL, DNAJB1, DNAJC3, EIF2AK2, EIF2S1, TRIM25, RIGI, IFIH1, NLRX1, MAVS, CHUK, IKBKB, IKBKG, NFKBIB, NFKBIA, NFKB1, RELA, CALCOCO2, TLR3, TICAM1, TRAF3, TBK1, IKBKE, IRF3, CREBBP, EP300, TLR4, TLR7, MYD88, IRAK4, IRF7, IL1A, IL1B, IL6, IL12A, IL12B, TNF, CXCL8, CCL2, CCL5, CXCL10, ICAM1, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNAR1, IFNAR2, JAK1, TYK2, SOCS3, STAT1, STAT2, IRF9, MX1, MX2, ADAR, PML, IFNG, IFNGR1, IFNGR2, JAK2, CIITA, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, NLRP3, PYCARD, CASP1, IL18, IL33, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, AKT1, AKT2, AKT3, CCND3, CDK4, CDK6, TNFSF10, TNFRSF10A, TNFRSF10B, FASLG, FAS, TNFRSF1A, TRADD, FADD, CASP8, BID, BAX, BAK1, VDAC1, SLC25A4, SLC25A5, SLC25A6, SLC25A31, CYCS, APAF1, CASP9, CASP3, CPSF4, CPSF4L, PABPN1, PABPN1L, BCL2L2-PABPN1, NXF1, NXF2, NXF2B, NXF3, NXT1, NXT2, HNRNPUL1, RAE1, NUP98, RSAD2, FDPS, PRKCA, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, ACTG1, ACTB, RAB11A, RAB11B, XPO1, KPNA1, KPNA2, KPNA7, KPNA6, KPNA5
## 35                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 TLR4, TICAM1, TLR2, TLR6, TLR9, MYD88, IRAK1, IRAK4, TRAF6, MAP2K4, MAPK8, MAPK10, MAPK9, MAPK1, MAPK3, MAPK11, MAPK12, MAPK13, MAPK14, FOS, JUN, IKBKG, CHUK, IKBKB, NFKBIA, NFKB1, RELA, IFNB1, CCL5, CCL2, TNF, IL12A, IL12B, IL6, CXCL8, CCL3, CCL3L1, CCL3L3, IL1B, PPP2R1B, PPP2R1A, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, PPP2CA, PPP2CB, IFNG, IFNGR1, IFNGR2, TNFRSF1A, NOS2, C3, CALR, C1QA, C1QB, C1QC, IL10, TGFB1, TGFB2, TGFB3, ACE, KNG1, BDKRB2, GNAQ, GNA11, GNA14, GNA15, PLCB1, PLCB2, PLCB3, PLCB4, GNAI1, GNAI3, GNAI2, GNAO1, GNAS, GNAL, ADCY1, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, AKT1, AKT2, AKT3, TGFBR2, TGFBR1, SMAD2, SERPINE1, FASLG, FAS, FADD, CASP8, CFLAR, CD3D, CD3E, CD3G, CD247, IL2
## 50                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1, CIITA, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IRGM, NOS2, SOCS1, MYD88, IRAK1, IRAK4, TRAF6, MAP3K7, TAB1, TAB2, MAPK1, MAPK3, MAPK8, MAPK10, MAPK9, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, CHUK, IKBKB, IKBKG, NFKBIA, NFKBIB, NFKB1, RELA, IL12A, IL12B, TNF, BCL2, BCL2L1, BIRC2, BIRC3, XIAP, BIRC7, LY96, TLR4, HSPA8, HSPA1A, HSPA2, HSPA1L, HSPA1B, HSPA6, TLR2, LAMA1, LAMA2, LAMA3, LAMA5, LAMA4, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, ITGA6, ITGB1, LDLR, TNFRSF1A, CASP8, CASP3, CYCS, CASP9, GNAI1, GNAI3, GNAI2, GNAO1, PIK3CG, PIK3R5, PIK3R6, PDPK1, AKT1, AKT2, AKT3, BAD, CD40LG, CD40, PPIF, CCR5, ALOX5, IL10, IL10RA, IL10RB, TYK2, STAT3, TGFB1, TGFB2, TGFB3
## 70                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     TLR1, TLR2, TLR6, LBP, CD14, LY96, TLR3, TLR4, TLR5, TLR7, TLR8, CTSK, TLR9, RAC1, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, TOLLIP, MYD88, TIRAP, FADD, CASP8, IRAK4, IRAK1, TRAF6, TAB1, TAB2, MAP3K7, IKBKG, CHUK, IKBKB, NFKBIA, NFKB1, RELA, MAP3K8, MAP2K1, MAP2K2, MAPK1, MAPK3, MAP2K3, MAP2K6, MAP2K4, MAP2K7, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, JUN, FOS, TNF, IL1B, IL6, IL12A, IL12B, CXCL8, CCL5, CCL3, CCL3L1, CCL3L3, CCL4, CCL4L2, CCL4L1, TICAM2, TICAM1, RIPK1, IRF5, IRF7, SPP1, IKBKE, TBK1, TRAF3, IRF3, CD40, CD80, CD86, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNAR1, IFNAR2, STAT1, CXCL10, CXCL9, CXCL11
## 83                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          TNF, TNFRSF1A, TRADD, FADD, CASP8, CASP10, CASP3, BID, BAX, CYCS, CASP9, APAF1, AKT1, AKT2, AKT3, BAD, BCL2, CAMK2A, CAMK2D, CAMK2B, CAMK2G, IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1, CIITA, RFX5, RFXANK, RFXAP, NFYA, NFYB, NFYC, CREB1, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, CD74, CREBBP, EP300, IL10, IL10RA, IL10RB, CTSS, CLEC4E, FCER1G, CLEC7A, SRC, SYK, CARD9, MALT1, BCL10, NOD2, RIPK2, HSPA9, HSPD1, LBP, TLR2, TLR1, TLR6, TLR4, CD14, TIRAP, MYD88, IRAK4, IRAK1, IRAK2, TRAF6, NFKB1, RELA, MAPK11, MAPK12, MAPK13, MAPK14, MAPK1, MAPK3, MAPK8, MAPK10, MAPK9, NOS2, IL6, IL12A, IL12B, IL18, IL23A, IL1A, IL1B, CEBPB, CEBPG, TLR9, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, CLEC4M, CD209, ARHGEF12, RHOA, LSP1, PLK3, KSR1, RAF1, TGFB1, TGFB2, TGFB3, CYP27B1, VDR, CAMP, C3, CR1, CR1L, ITGAX, ITGB2, ITGAM, PLA2R1, MRC1, MRC2, SPHK1, SPHK2, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PIK3C3, RAB5A, RAB5B, RAB5C, EEA1, RAB7A, CTSD, TCIRG1, ATP6V0A2, ATP6V0A4, ATP6V0A1, ATP6V0D1, ATP6V0D2, ATP6V1H, ATP6AP1, ATP6V0C, ATP6V0B, LAMP1, LAMP2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, CORO1A, IGH, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCGR3B
## 86                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          TMPRSS2, ACE2, NRP1, ACE, MAS1, AGTR1, CYBB, NFKB1, RELA, TNF, IL6, IL1B, IL12A, IL12B, MMP3, MMP1, CCL2, CXCL8, ADAM17, TNFRSF1A, NFKBIA, NFKBIB, HBEGF, EGFR, IL6R, IL6ST, JAK1, TYK2, STAT3, IL2, CSF3, CSF2, CXCL10, RPS2, RPS3, RPS3A, RPS4Y1, RPS4X, RPS4Y2, RPS5, RPS6, RPS7, RPS8, RPS9, RPS10, RPS10-NUDT3, RPS11, RPS12, RPS13, RPS14, RPS15, RPS15A, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS27, RPS27L, RPS27A, RPS28, RPS29, FAU, RPSA, RPL3L, RPL3, RPL4, RPL5, RPL6, RPL7, RPL7A, RPL8, RPL9, RPL10L, RPL10, RPL10A, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL15, RPL17, RPL17-C18orf32, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL22, RPL23, RPL23A, RSL24D1, RPL24, RPL26, RPL26L1, RPL27, RPL27A, RPL28, RPL29, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36, RPL37, RPL37A, RPL38, RPL39, UBA52, RPL41, RPL36AL, RPL36A, RPL36A-HNRNPH2, RPLP0, RPLP1, RPLP2, IGH, FCGR2A, SYK, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PLCG1, PLCG2, PRKCA, PRKCB, PRKCG, MAPK1, MAPK3, MAPK11, MAPK12, MAPK13, MAPK14, TLR2, TLR4, MYD88, TLR7, TLR8, IRAK4, IRAK1, TRAF6, MAP3K7, TAB2, MAPK8, MAPK10, MAPK9, FOS, JUN, CHUK, IKBKB, IKBKG, NLRP3, CASP1, TLR3, RIGI, ISG15, IFIH1, MAVS, TRAF3, IKBKE, TBK1, IRF3, CGAS, STING1, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNAR1, IFNAR2, STAT1, STAT2, IRF9, ADAR, OAS1, OAS2, OAS3, MX1, MX2, EIF2AK2, C5AR1, C3AR1, C3, CFB, CFD, C5, C6, C7, C8A, C8B, C8G, C9, SELP, VWF, C1QA, C1QB, C1QC, C1R, C1S, C2, C4A, C4B, MBL2, MASP1, MASP2, F2, F13A1, F13B, FGA, FGB, FGG
## 99                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      TLR2, TLR4, MYD88, IRAK1, IRAK4, TRAF6, MAP3K7, TAB1, TAB2, NFKBIB, NFKBIA, NFKB1, RELA, IL1A, IL1B, IL12A, IL12B, TNF, IL4, NOS2, IL10, TGFB1, TGFB2, TGFB3, C3, CR1, CR1L, ITGAM, ITGB2, IGH, FCGR1A, FCGR2A, FCGR2C, FCGR3A, FCGR3B, ITGA4, ITGB1, PTGS2, PRKCB, NCF1, NCF2, NCF4, CYBB, CYBA, MAPK1, MAPK3, ELK1, FOS, JUN, MAPK11, MAPK12, MAPK13, MAPK14, IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, MARCKSL1, EEF1A1, EEF1A2, PTPN6
## 112                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            ITGA5, ITGB1, ITGAM, ITGB2, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, RHOA, CFL1, CFL2, CASP3, CASP7, CASP1, PYCARD, NLRP3, IL1B, C1QA, C1QB, C1QC, C1R, C1S, C2, C4A, C4B, C3, C5, SERPING1, C4BPA, C4BPB, LY96, TLR4, CD14, TIRAP, MYD88, IRAK4, IRAK1, TRAF6, NFKB1, RELA, TICAM2, TICAM1, IRF3, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, MAPK1, MAPK3, FOS, JUN, IL6, IL12A, IL12B, IL23A, TNF, IL10, IRF1, IRF8, SFTPA1, SFTPA2, GNAI1, GNAI3, GNAI2, CXCL8, CXCL5, CXCL6, NOD1, IL1A, NOS2
## 130                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           CLEC7A, LSP1, HRAS, KRAS, NRAS, MRAS, RRAS, RRAS2, RAF1, RELA, RELB, IL12A, IL12B, IL1B, SYK, PTPN11, MAP3K14, CHUK, NFKB2, PLCG2, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, NFATC4, IL2, IL10, EGR2, EGR3, PTGS2, PRKCD, MAPK1, MAPK3, NLRP3, PYCARD, CASP1, CARD9, BCL10, MALT1, CASP8, IKBKG, IKBKB, NFKBIA, NFKB1, TNF, IL6, IL23A, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, JUN, CBLB, CLEC6A, FCER1G, CLEC4M, CD209, ARHGEF12, RHOA, PAK1, KSR1, PLK3, SRC, IKBKE, STAT1, IRF9, STAT2, IL17D, CYLD, BCL3, CCL17, CCL22, MAPKAPK2, CLEC4E, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MDM2, IRF1, CLEC4D, CLEC1B
## 36                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      PRKACA, PRKACB, PRKACG, ITGAV, ITGB3, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, STAT1, TP53, ESR1, THRB, NCOR1, SIN3A, HDAC1, HDAC2, HDAC3, THRA, RXRA, RXRB, RXRG, KAT2B, KAT2A, NCOA1, NCOA2, NCOA3, CREBBP, EP300, MED4, MED12L, MED12, MED13L, MED13, MED14, MED16, MED17, MED24, MED27, MED30, MED1, CCND1, GATA4, RCAN1, HIF1A, MYC, MYH7, MYH6, ATP2A1, ATP2A3, ATP2A2, PLN, WNT4, CTNNB1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, BMP4, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB, PRKCG, SLC9A1, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, FXYD2, SLC16A2, SLC16A10, SRC, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PDPK1, AKT1, AKT2, AKT3, GSK3B, MDM2, TSC2, RHEB, MTOR, TBC1D4, PFKFB2, BAD, FOXO1, CASP9, RCAN2, SLC2A1, PFKM, PFKP, PFKL, SLCO1C1, DIO1, DIO2, DIO3, ACTG1, ACTB
## 160                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     FCGR3A, FCGR3B, SYK, MAP3K7, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, SIGLEC9, CYBB, NCF1, CYBA, NCF2, NCF4, RAC1, RAC2, TLR7, TLR8, ELANE, MPO, ACTG1, ACTB, VDAC1, VDAC2, VDAC3, SLC25A4, SLC25A5, SLC25A6, SLC25A31, PPIF, PADI4, IGH, FCGR1A, FCGR2A, ITGAM, ITGB2, ITGAL, CLEC7A, SRC, PLCB1, PLCB2, PLCB3, PLCB4, PLCG1, PLCG2, PRKCA, PRKCB, PRKCG, ATG7, FPR1, FPR3, FPR2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MTOR, NFKB1, RELA, C3, CR1, CR1L, C5, C5AR1, HMGB1, TLR2, TLR4, MAPK11, MAPK12, MAPK13, MAPK14, ITGA2B, ITGB3, FGA, FGB, FGG, GP1BA, VWF, SELP, SELPLG, AGER, CASP4, CASP1, GSDMD, HAT1, H2AX, H2AC20, H2AC12, H2AC1, H2AC25, H2AB3, H2AC8, H2AC4, MACROH2A2, MACROH2A1, H2AC19, H2AJ, H2AB1, H2AC17, H2AC18, H2AC11, H2AC21, H2AZ2, H2AC7, H2AZ1, H2AC15, H2AC6, H2AC13, H2AC14, H2AC16, H2AB2, H2BC15, H2BC9, H2BC14, H2BW1, H2BC1, H2BC18, H2BC17, H2BC3, H2BC8, H2BC13, H2BC4, H2BC5, H2BC6, H2BC10, H2BC21, H2BC11, H2BC12, H2BC26, H2BC7, H2BW2, H2BK1, H2BC12L, H4C16, H4C15, H4C9, H4C4, H4C6, H4C12, H4C11, H4C3, H4C8, H4C2, H4C5, H4C13, H4C14, H4C1, H4C7, H3-5, H3-3B, H3C4, H3C3, H3C1, H3-3A, H3-4, H3C14, H3C15, H3C13, H3C6, H3C11, H3C8, H3C12, H3C10, H3C2, H3C7, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, HDAC10, HDAC11, AZU1, CTSG, CAMP, CLCN3, CLCN4, CLCN5, AQP9
## 38                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        NGF, BDNF, NTF4, NTF3, NTRK1, NTRK2, NTRK3, SH2B2, SH2B1, SH2B3, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, BRAF, MAP2K1, MAP2K2, MAPK1, MAPK3, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, RPS6KA5, ATF4, BCL2, KIDINS220, FRS2, CRK, CRKL, RAPGEF1, RAP1A, RAP1B, MAP3K3, MAP2K5, MAPK7, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, SHC1, SHC2, SHC3, SHC4, GAB1, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, AKT1, AKT2, AKT3, NFKBIB, NFKBIA, NFKBIE, NFKB1, RELA, FOXO3, FASLG, BAD, GSK3B, PDPK1, IRS1, PLCG1, PLCG2, PRKCD, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, CAMK4, ABL1, PTPN11, MATK, NGFR, ARHGDIB, ARHGDIA, ARHGDIG, RHOA, CDC42, RAC1, MAP3K1, MAP3K5, MAP2K7, MAPK8, MAPK10, MAPK9, JUN, TP53, BAX, TP73, TRAF6, ZNF274, PRDM4, MAGED1, BEX3, YWHAE, RIPK2, IRAK1, IRAK2, IRAK3, IRAK4, IKBKB, SORT1, PSEN1, PSEN2
## 63                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               GNRH1, GNRH2, GNRHR, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, ATF4, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, PRKCA, PRKCB, PRKCD, CACNA1C, CACNA1D, CACNA1F, CACNA1S, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, MAPK7, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PLD1, PLD2, SRC, CDC42, MAP2K4, MAP2K7, MAPK8, MAPK10, MAPK9, JUN, LHB, CGA, FSHB, PTK2B, MMP2, MMP14, HBEGF, EGFR, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, ELK1, EGR1
## 98                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            KNG1, BDKRB1, BDKRB2, HTR2A, HTR2B, HTR2C, HRH1, P2RY2, GNAQ, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PLA2G6, ALOX12, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, PRKCE, PPP1CA, PPP1CB, PPP1CC, TRPA1, TRPV1, ASIC1, ASIC2, ASIC3, ASIC4, ASIC5, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, IL1B, IL1R1, IL1RAP, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, NGF, NTRK1, PLCG1, PLCG2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PRKCD, SRC, TRPM8, PTGER2, PTGER4, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, TRPV4, F2RL1, CYP2J2, PRKCA, PRKCB, PRKCG, PRKCH, PRKCQ, IGF1, TRPV2, TRPV3
## 41                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          RIGI, IFIH1, MAVS, DHX58, TRAF3, TANK, AZI2, TBKBP1, IKBKG, TBK1, IKBKE, IRF3, IRF7, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNW1, IFNE, IFNK, TRADD, FADD, RIPK1, CASP8, CASP10, CHUK, IKBKB, NFKBIB, NFKBIA, NFKB1, RELA, TRAF2, MAP3K7, TRAF6, MAP3K1, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14, CXCL8, TNF, IL12A, IL12B, CXCL10, TRIM25, CYLD, RNF125, ISG15, ATG5, ATG12, NLRX1, STING1, OTUD5, SIKE1, DDX3X, PIN1, TKFC
## 48                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             NOD1, RIPK2, IKBKG, CHUK, IKBKB, NFKBIB, NFKBIA, NFKB1, RELA, IL1B, IL18, IL6, TNF, CXCL8, CXCL1, CXCL2, CXCL3, CCL2, CCL5, CAMP, DEFA1, DEFA3, DEFA4, DEFA5, DEFA6, DEFA1B, DEFB4A, DEFB4B, DEFB103A, DEFB103B, NOD2, MAP3K7, TAB1, TAB2, TAB3, MAPK1, MAPK3, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14, JUN, ATG16L1, ATG5, ATG12, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3C, MAP1LC3B, MAP1LC3A, MAP1LC3B2, SUGT1, SHARPIN, RBCK1, RNF31, XIAP, CARD6, TRIP6, ERBIN, BIRC2, BIRC3, TRAF2, TRAF5, TRAF6, CARD9, TNFAIP3, MAVS, TRAF3, TBK1, IKBKE, TANK, IRF3, IRF7, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, NLRX1, ANTXR2, ANTXR1, NLRP1, PYCARD, CASP1, BCL2, BCL2L1, CTSB, NLRP3, PANX1, P2RX7, TRPM2, TRPM7, TRPV2, CASR, GPRC6A, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, VDAC1, VDAC2, VDAC3, MCU, OAS1, OAS2, OAS3, RNASEL, DHX33, MFN1, MFN2, RIPK1, RIPK3, DNM1L, NAMPT, CYBB, CYBA, TXNIP, TXN, TXN2, NEK7, BRCC3, HSP90AA1, HSP90AB1, CARD8, PYDC1, PYDC2, MEFV, PSTPIP1, CASP8, FADD, CASP12, CARD18, CARD16, NLRP6, NLRP7, NLRP12, NAIP, NLRC4, PRKCD, GBP2, GBP5, AIM2, IFI16, TP53BP1, PYDC5, RHOA, PKN1, PKN2, YWHAE, GBP1, GBP3, GBP4, GBP7, CASP5, CASP4, GSDMD, IFNAR1, IFNAR2, JAK1, TYK2, STAT1, STAT2, IRF9, TLR4, TICAM1, MYD88, IRAK4, STING1
## 54                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 IL25, IL17RA, IL17RB, TRADD, FADD, CASP3, CASP8, TRAF3IP2, TRAF6, NFKB1, RELA, FOS, FOSB, JUN, JUND, FOSL1, IL4, IL5, IL13, CCL17, CCL11, IL17A, IL17F, IL17RC, TRAF3, ANAPC5, TNFAIP3, HSP90AA1, HSP90AB1, HSP90B1, TBK1, TAB2, TAB3, MAP3K7, IKBKG, CHUK, IKBKB, NFKBIA, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK15, CEBPB, TRAF4, IKBKE, USP25, TRAF5, TRAF2, SRSF1, ELAVL1, GSK3B, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL8, CXCL10, CCL2, CCL7, CCL20, IL6, TNF, PTGS2, CSF3, CSF2, DEFB4A, DEFB4B, MUC5AC, MUC5B, S100A7, S100A7A, S100A8, S100A9, LCN2, MMP1, MMP3, MMP9, MMP13, IL17C, IL17RE, IL1B, IFNG, IL17B, IL17D
## 44                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        ASPDH, QPRT, NAPRT, PNP, NMRK1, NMRK2, NT5C2, NT5C1A, NT5C1B, NT5C, NT5M, NT5C1B-RDH14, NT5DC4, NT5E, NMNAT3, NMNAT1, NMNAT2, ENPP1, ENPP3, NUDT12, NADSYN1, NAMPT, CD38, BST1, SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7, NADK, NADK2, NNT, NNMT, AOX1
## 51                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             SPTLC1, SPTLC2, SPTLC3, CERS1, CERS2, CERS4, CERS3, CERS6, CERS5, DEGS1, DEGS2, SMPD1, SGMS1, SGMS2, TNF, TNFRSF1A, NSMAF, SMPD2, ASAH1, ASAH2, ACER2, ACER1, TRADD, TRAF2, CTSD, BID, BAX, MAP3K5, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14, PRKCZ, AKT1, AKT2, AKT3, BCL2, PPP2CA, PPP2CB, PPP2R1B, PPP2R1A, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, PPP2R3B, PPP2R3C, PPP2R3A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, PPP2R5A, TP53, FCER1A, MS4A2, FCER1G, FYN, GAB2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PLD1, PLD2, SPHK1, SPHK2, KNG1, ADORA1, ADORA3, BDKRB2, OPRD1, GNAI1, GNAI3, GNAI2, PLCB1, PLCB2, PLCB3, PLCB4, PRKCE, MAPK1, MAPK3, SGPP1, SGPP2, ABCC1, SGPL1, S1PR1, S1PR2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, PDPK1, NOS3, RAC1, RAC2, RAC3, S1PR3, GNAQ, PRKCA, PRKCB, PRKCG, S1PR4, S1PR5, GNA12, GNA13, RHOA, ROCK1, ROCK2, PTEN, NFKB1, RELA
## 59                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADCY10, PRKACA, PRKACB, PRKACG, LIPE, APLN, APELA, APLNR, GNAI1, GNAI3, GNAI2, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, RYR1, RYR2, RYR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, NOS1, NOS2, NOS3, PRKCE, SLC9A1, SLC8A1, SLC8A2, SLC8A3, MYLK, MYLK2, MYLK3, MYLK4, MYL2, MYL3, MYL4, HRAS, KRAS, NRAS, RRAS, RRAS2, MRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, RPS6KB1, RPS6KB2, RPS6, PIK3CG, PIK3R5, PIK3R6, AKT1, AKT2, AKT3, MTOR, EGR1, SPP1, JAG1, NOTCH3, CCND1, PDE3B, PIK3C3, PIK3R4, BECN1, BECN2, MAP1LC3C, MAP1LC3B, MAP1LC3A, MAP1LC3B2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, PLIN1, PPARGC1A, UCP1, NRF1, TFAM, KLF2, SPHK1, SPHK2, GNA13, CAMK4, HDAC4, HDAC5, MEF2A, BORCS8-MEF2B, MEF2B, MEF2C, MEF2D, TGFBR1, SMAD2, SMAD3, SMAD4, ACTA2, CDH1, CCN2, AGTR1, SERPINE1, PLAT
## 127                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  OXT, OXTR, GNAQ, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PTGS2, MAP2K5, MAPK7, JUN, FOS, MEF2C, CCND1, ELK1, RYR1, RYR2, RYR3, CD38, TRPM2, KCNJ2, KCNJ12, KCNJ18, KCNJ4, KCNJ14, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, PRKCB, PRKCG, EEF2K, EEF2, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CACNB1, CACNB2, CACNB3, CACNB4, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, NFATC4, RGS2, RCAN1, CAMKK2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, CAMK1D, CAMK1G, CAMK1, CAMK2A, CAMK2D, CAMK2B, CAMK2G, CAMK4, NOS3, GUCY1A2, GUCY1A1, GUCY1B1, NPPA, NPR1, NPR2, MYLK, MYLK2, MYLK3, MYLK4, MYL6B, MYL6, MYL9, ACTG1, ACTB, RHOA, ROCK1, ROCK2, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PPP1R12C, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, GNAI1, GNAI3, GNAI2, GNAO1, PIK3CG, PIK3R5, PIK3R6, SRC, KCNJ3, KCNJ6, KCNJ9, KCNJ5, EGFR, CDKN1A
## 62                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           GSTP1, CDKN1B, CDK2, CCNE1, CCNE2, RB1, E2F1, E2F2, E2F3, TMPRSS2, ERG, PLAU, PLAT, MMP3, MMP9, ZEB1, IL1R2, SPINT1, ETV5, INS, PDGFA, PDGFB, PDGFC, PDGFD, EGF, TGFA, IGF1, INSRR, PDGFRA, PDGFRB, FGFR1, FGFR2, EGFR, ERBB2, IGF1R, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PTEN, PDPK1, NKX3-1, AKT1, AKT2, AKT3, CASP9, BAD, FOXO1, CDKN1A, MDM2, TP53, GSK3B, CREB1, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, CTNNB1, CREBBP, EP300, TCF7, TCF7L1, TCF7L2, LEF1, CCND1, CHUK, IKBKB, IKBKG, NFKBIA, NFKB1, RELA, BCL2, MTOR, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, SRD5A2, AR, HSP90AA1, HSP90AB1, HSP90B1, KLK3
## 75                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         IGH, FCER1A, MS4A2, FCER1G, SYK, LYN, BTK, INPP5D, PLCG1, PLCG2, PRKCA, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PDPK1, AKT1, AKT2, AKT3, RAC1, RAC2, RAC3, MAP2K4, MAP2K7, MAP2K3, MAP2K6, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14, IL4, IL13, IL3, IL5, CSF2, TNF, LCP2, VAV3, VAV1, VAV2, FYN, GAB2, LAT, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, ALOX5, ALOX5AP
## 79                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             KRAS, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, ARHGEF6, RAC1, RAC2, RAC3, NFKB1, RELA, AKT1, AKT2, AKT3, CHUK, IKBKB, IKBKG, BAD, BCL2L1, CASP9, ARAF, BRAF, RAF1, MAP2K1, MAPK1, MAPK3, MAPK8, MAPK10, MAPK9, RALGDS, RALA, RALB, RALBP1, CDC42, PLD1, PLD2, TGFA, EGF, EGFR, ERBB2, MTOR, RPS6KB1, RPS6KB2, JAK1, STAT3, STAT1, VEGFA, CDKN2A, CDK4, CDK6, CCND1, RB1, E2F1, E2F2, E2F3, TP53, CDKN1A, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD2, SMAD3, SMAD4, BRCA2, RAD51
## 81                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              PRL, PRLR, JAK2, SHC1, SHC2, SHC3, SHC4, SRC, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, FOXO3, GALT, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, FOS, MAPK8, MAPK10, MAPK9, MAPK11, MAPK12, MAPK13, MAPK14, CCND1, GSK3B, CISH, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOCS6, STAT1, STAT3, STAT5A, STAT5B, TNFSF11, TNFRSF11A, NFKB1, RELA, ELF5, CSN2, CGA, LHB, LHCGR, CYP17A1, ESR1, ESR2, IRF1, TH, SLC2A2, GCK, CCND2, INS
## 89                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          FHIT, RARB, RXRA, RXRB, RXRG, CDKN2A, CDK4, CDK6, CCND1, RB1, E2F1, E2F2, E2F3, KRAS, RASSF1, RASSF5, STK4, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PDPK1, AKT1, AKT2, AKT3, BAD, CASP9, FOXO3, EGF, TGFA, EGFR, ERBB2, HGF, MET, GRB2, SOS1, SOS2, HRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PLCG1, PLCG2, PRKCA, PRKCB, PRKCG, TP53, CDKN1A, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK, KIF5A, KIF5B, KIF5C, RET, EML4, ALK, JAK3, STAT3, STAT5A, STAT5B
## 100                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            EGF, TGFA, AREG, EGFR, ERBB2, PLCG1, PLCG2, CAMK2A, CAMK2D, CAMK2B, CAMK2G, PRKCA, PRKCB, PRKCG, CBL, CBLB, STAT5A, STAT5B, SRC, PTK2, CRK, CRKL, ABL1, ABL2, NCK1, NCK2, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, BUB1B-PAK6, MAP2K4, MAP2K7, MAPK8, MAPK10, MAPK9, JUN, ELK1, BTC, HBEGF, EREG, ERBB3, NRG1, NRG2, ERBB4, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, MYC, GAB1, NRG3, NRG4, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MTOR, RPS6KB1, RPS6KB2, EIF4EBP1, BAD, GSK3B, CDKN1B, CDKN1A
## 102                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 VEGFA, KDR, SH2D2A, PLCG1, PLCG2, PRKCA, PRKCB, PRKCG, SPHK1, SPHK2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC2, PTGS2, PTK2, SHC2, PXN, CDC42, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK3, HSPB1, SRC, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, RAC1, RAC2, RAC3, AKT1, AKT2, AKT3, NOS3, CASP9, BAD
## 106                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                KIT, FLT3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, CHUK, IKBKB, IKBKG, NFKB1, RELA, BAD, MTOR, EIF4EBP1, RPS6KB1, RPS6KB2, GRB2, SOS1, SOS2, HRAS, NRAS, KRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, STAT3, STAT5A, STAT5B, PIM1, PIM2, RUNX1, CSF1R, MPO, CSF2, IL3, RUNX1T1, PML, RARA, ZBTB16, CEBPA, PER2, SPI1, CD14, ITGAM, FCGR1A, CEBPE, BCL2A1, CCNA2, CCNA1, MYC, DUSP6, JUP, TCF7, TCF7L1, TCF7L2, LEF1, CCND1, PPARD
## 108                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         FGF1, FGF2, FGF3, FGF4, FGF17, FGF6, FGF7, FGF8, FGF9, FGF10, FGF16, FGF5, FGF18, FGF20, FGF22, FGF19, FGF21, FGF23, HGF, IGF1, PDGFA, PDGFB, PDGFC, PDGFD, EGF, FGFR1, MET, IGF1R, PDGFRA, PDGFRB, EGFR, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, CCND1, CDK4, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, BAD, PTEN, CDKN2A, MDM2, TP53, CDKN1A, CDK6, RB1, E2F1, E2F2, E2F3, CDH1, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK, MITF
## 113                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       BCR, ABL1, CRK, CRKL, CBL, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, BAD, BCL2L1, CHUK, IKBKB, IKBKG, NFKBIA, NFKB1, RELA, MDM2, TP53, CDKN1B, GRB2, GAB2, PTPN11, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, ARAF, BRAF, MAP2K1, MAP2K2, MAPK1, MAPK3, SHC1, SHC2, SHC3, SHC4, MYC, STAT5A, STAT5B, CDKN2A, CDKN1A, CCND1, CDK4, CDK6, RB1, E2F1, E2F2, E2F3, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD3, SMAD4, MECOM, RUNX1, CTBP1, CTBP2, HDAC1, HDAC2
## 115                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  EGF, TGFA, EGFR, PDGFA, PDGFB, PDGFRA, PDGFRB, IGF1, IGF1R, PLCG1, PLCG2, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK1D, CAMK1G, CAMK1, CAMK2A, CAMK2D, CAMK2B, CAMK2G, CAMK4, PRKCA, PRKCB, PRKCG, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MTOR, PTEN, CDKN2A, MDM2, TP53, CDKN1A, CCND1, CDK4, CDK6, RB1, E2F1, E2F2, E2F3, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK
## 119                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GSK3B, AXIN1, AXIN2, CTNNB1, APC, APC2, TCF7, TCF7L1, TCF7L2, LEF1, BIRC5, MYC, CCND1, KRAS, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, BAD, CASP9, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, JUN, FOS, RALGDS, RALA, RALB, RAC1, RAC2, RAC3, RHOA, MAPK8, MAPK10, MAPK9, DCC, CASP3, APPL1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD2, SMAD3, SMAD4, MLH1, MSH2, MSH3, MSH6, BAX, PMAIP1, BCL2L11, BBC3, BCL2, CYCS, TP53, CDKN1A, GADD45A, GADD45B, GADD45G, BAK1, DDB2, POLK, EGF, TGFA, EREG, AREG, EGFR, GRB2, SOS1, SOS2, HRAS, NRAS, MTOR, RPS6KB1, RPS6KB2
## 128                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            EGF, PDGFA, PDGFB, PDGFC, PDGFD, EGFR, PDGFRA, PDGFRB, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, RALGDS, MAPK8, MAPK10, MAPK9, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PDPK1, AKT1, AKT2, AKT3, TSC1, TSC2, RHEB, MTOR, RPS6KB1, RPS6KB2, EIF4EBP1, PIP5K1C, PIP5K1A, PIP5K1B, WAS, RAC1, RAC2, RAC3, WASF1, WASF2, WASF3, SP1, PLD1, PLD2, SLC5A7, SLC44A1, SLC44A4, SLC44A5, SLC44A2, SLC44A3, SLC22A1, SLC22A2, SLC22A3, SLC22A5, SLC22A4, CHKA, CHKB, HIF1A, JUN, FOS, PCYT1B, PCYT1A, CHPT1, PLCG1, PLPP1, PLPP3, PLPP2, DGKZ, DGKD, DGKI, DGKA, DGKE, DGKB, DGKH, DGKG, DGKQ, DGKK, PRKCA, PRKCB, PRKCG, LYPLA1, GPCPD1
## 131                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               EGF, EGFR, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PTEN, PDPK1, ILK, AKT1, AKT2, AKT3, CASP9, BAD, FOXO3, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, ELK1, MLH1, CDH1, CTNNB1, CTNNA3, CTNNA1, CTNNA2, AXIN1, AXIN2, APC, APC2, GSK3B, TCF7, TCF7L1, TCF7L2, LEF1, MYC, CCND1, TP53, CDKN1A, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK, ERBB2
## 134                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             IGH, CD79A, CD79B, LYN, SYK, BTK, DAPP1, BLNK, VAV3, VAV1, VAV2, RAC1, RAC2, RAC3, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, GRB2, SOS1, SOS2, RASGRP3, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, FOS, JUN, PRKCB, CARD11, BCL10, MALT1, CHUK, IKBKB, IKBKG, NFKB1, RELA, NFKBIA, NFKBIB, NFKBIE, IFITM1, CD81, CD19, CR2, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, AKT1, AKT2, AKT3, GSK3B, FCGR2B, INPP5D, INPPL1, LILRB2, LILRB1, LILRB5, LILRB4, LILRA1, LILRB3, LILRA3, LILRA2, LILRA4, LILRA6, LILRA5, CD22, CD72, PTPN6, PIK3AP1
## 140                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              HIF1A, EPAS1, EGLN1, EGLN3, EGLN2, VHL, ELOC, ELOB, RBX1, CUL2, ARNT, ARNT2, CREBBP, EP300, SLC2A1, VEGFA, TGFB1, TGFB2, TGFB3, PDGFB, TGFA, HGF, MET, GAB1, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, BAD, CRK, CRKL, RAPGEF1, RAP1A, RAP1B, PTPN11, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, ETS1, JUN, RAC1, CDC42, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, BUB1B-PAK6, PRCC, TFE3, CDKN1A, FH, FLCN
## 146                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                IGH, FCGR1A, FCGR2A, FCGR3A, FCGR3B, PTPRC, HCK, LYN, SYK, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, RPS6KB1, RPS6KB2, PLCG1, PLCG2, PRKCD, PRKCE, RAF1, MAP2K1, MAPK1, MAPK3, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PLA2G6, MARCKS, MARCKSL1, PLD1, PLD2, PLPP1, PLPP3, PLPP2, SPHK1, SPHK2, PRKCA, PRKCB, PRKCG, NCF1, GSN, SCIN, VAV3, VAV1, VAV2, CDC42, WAS, VASP, ACTR2, ACTR3B, ACTR3C, ACTR3, ARPC1B, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, RAC1, RAC2, WASF1, WASF2, WASF3, PAK1, LIMK1, LIMK2, CFL1, CFL2, PIP5K1C, PIP5K1A, PIP5K1B, ARF6, CRK, CRKL, DOCK1, ASAP1, ASAP3, ASAP2, FCGR2B, INPP5D, INPPL1, GAB2, LAT, DNM2, AMPH, BIN1, MYO10
## 166                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    HLA-A, HLA-B, HLA-C, HLA-G, HLA-E, KIR3DL2, KIR3DL1, KIR3DL3, KIR2DL2, KIR2DL1, KIR2DL3, KIR2DL5A, KLRC1, KLRD1, PTPN6, PTPN11, ICAM1, ICAM2, ITGAL, ITGB2, PTK2B, VAV3, VAV1, VAV2, RAC1, RAC2, RAC3, PAK1, MAP2K1, MAP2K2, MAPK1, MAPK3, TNF, CSF2, IFNG, KIR2DS1, KIR2DS3, KIR2DS4, KIR2DS5, KIR2DS2, KLRC2, KLRC3, NCR2, TYROBP, LCK, IGH, FCGR3A, FCGR3B, NCR1, NCR3, FCER1G, CD247, ZAP70, SYK, LCP2, LAT, PLCG1, PLCG2, SH3BP2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, FYN, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MICB, MICA, ULBP1, ULBP2, ULBP3, KLRK1, KLRC4-KLRK1, HCST, CD48, CD244, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, PRKCA, PRKCB, PRKCG, SH2D1B, SH2D1A, IFNGR1, IFNGR2, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNAR1, IFNAR2, TNFSF10, TNFRSF10A, TNFRSF10B, FASLG, FAS, GZMB, PRF1, CASP3, BID, RAET1G, RAET1L, RAET1E
## 66                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, PPBP, CXCL8, CXCL9, CXCL10, CXCL11, CXCL12, CXCL13, CXCL16, PF4, PF4V1, CXCL14, XCL1, XCL2, CX3CL1, CCL1, CCL2, CCL3, CCL3L1, CCL3L3, CCL4, CCL4L2, CCL4L1, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, CCL15, CCL23, CCL16, CCL17, CCL18, CCL19, CCL20, CCL21, CCL22, CCL24, CCL25, CCL26, CCL27, CCL28, CXCR2, CXCR1, CXCR3, CXCR4, CXCR5, CXCR6, XCR1, CX3CR1, CCR8, CCR6, CCR9, CCR4, CCR7, CCR2, CCR5, CCR1, CCR3, CCR10, JAK2, JAK3, STAT1, STAT2, STAT3, STAT5B, GNAI1, GNAI3, GNAI2, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, LYN, HCK, FGR, SRC, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, BRAF, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PIK3CG, PIK3R5, PIK3R6, PRKCZ, AKT1, AKT2, AKT3, FOXO3, CHUK, IKBKB, IKBKG, NFKBIA, NFKBIB, NFKB1, RELA, BAD, GSK3A, GSK3B, ITK, VAV3, VAV1, VAV2, RAC1, RAC2, RAC3, PAK1, CDC42, WAS, RHOA, ROCK1, ROCK2, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, PREX1, ELMO1, DOCK2, PTK2, PXN, BCAR1, CRK, CRKL, PTK2B, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, PLCG1, PLCG2, RASGRP2, RAP1A, RAP1B, PARD3, TIAM1, PRKCB, PRKCD, NCF1, GRK7, GRK1, GRK2, GRK3, GRK4, GRK5, GRK6, ARRB1, ARRB2
## 67                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     TGFB2, TGFB3, TGFB1, TGFBR1, TGFBR2, SMAD2, SMAD3, SMAD4, CDKN1B, FN1, COL1A1, COL1A2, COL3A1, COL4A2, COL4A4, COL4A6, COL4A1, COL4A5, COL4A3, AGT, AGTR1, AGER, NOX1, CYBB, NOX4, PLCD1, PLCD3, PLCD4, PLCB1, PLCB2, PLCB3, PLCB4, PLCG1, PLCG2, PLCE1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCZ, MAPK1, MAPK3, JUN, VEGFA, VEGFB, VEGFC, VEGFD, CCL2, SERPINE1, SELE, VCAM1, ICAM1, MMP2, IL1A, IL1B, IL6, CXCL8, TNF, F3, EDN1, THBD, MAPK11, MAPK12, MAPK13, MAPK14, RELA, NFKB1, MAPK8, MAPK10, MAPK9, DIAPH1, RAC1, CDC42, HRAS, KRAS, NRAS, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, NOS3, FOXO1, BCL2, BAX, CASP3, JAK2, STAT3, PIM1, NFATC1, STAT1, STAT5A, STAT5B, CCND1, CDK4, EGR1
## 69                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 LPAR1, LPAR2, LPAR4, LPAR5, CXCL12, CXCR4, F2, F2R, INS, EGF, FGF1, FGF2, FGF3, FGF4, FGF17, FGF6, FGF7, FGF8, FGF9, FGF10, FGF16, FGF5, FGF18, FGF20, FGF22, FGF19, FGF21, FGF23, PDGFA, PDGFB, PDGFC, PDGFD, INSRR, EGFR, FGFR1, FGFR2, FGFR3, FGFR4, PDGFRA, PDGFRB, FN1, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGA10, ITGA11, ITGAV, ITGAL, ITGAM, ITGAX, ITGAD, ITGAE, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KNG1, BDKRB1, BDKRB2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, C5, C6, C7, C8A, C8B, C8G, C9, GNA12, GNA13, GNG12, FGD1, FGD3, PTK2, BCAR1, CRK, CRKL, DOCK1, SRC, SOS1, SOS2, HRAS, KRAS, NRAS, RRAS, RRAS2, MRAS, ARHGEF6, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, VAV3, VAV1, VAV2, TIAM1, ARAF, BRAF, RAF1, MOS, MAP2K1, MAP2K2, MAPK1, MAPK3, AKT1, AKT2, AKT3, RGCC, ARHGEF1, ARHGEF12, ARHGAP35, RHOA, RAC1, RAC2, RAC3, CDC42, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, BUB1B-PAK6, ARHGEF7, GIT1, ROCK1, ROCK2, MYLK, MYLK2, MYLK3, MYLK4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PPP1R12C, MYL2, MYL5, MYL7, MYL9, MYL10, MYL12B, MYL12A, MYL11, MYH9, MYH10, MYH11, MYH14, DIAPH1, DIAPH2, SLC9A1, PIP5K1C, PIP5K1A, PIP5K1B, PIP4K2C, PIP4K2A, PIP4K2B, PIKFYVE, LIMK1, LIMK2, DIAPH3, BAIAP2, ENAH, WASL, WASF2, CYFIP1, CYFIP2, NCKAP1, NCKAP1L, ABI2, BRK1, WASF1, ACTR2, ACTR3B, ACTR3C, ACTR3, ARPC1B, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, ACTG1, ACTB, PFN3, PFN1, PFN2, PFN4, PXN, EZR, RDX, MSN, TMSB4X, TMSB4Y, CFL1, CFL2, SSH1, SSH3, SSH2, VCL, IQGAP1, IQGAP2, IQGAP3, GSN, SCIN, ACTN1, ACTN4, APC, APC2, ARHGEF4, SPATA13
## 155                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      COL1A1, COL1A2, COL2A1, COL4A2, COL4A4, COL4A6, COL4A1, COL4A5, COL4A3, COL6A1, COL6A2, COL6A3, COL6A6, COL6A5, COL9A1, COL9A2, COL9A3, LAMA1, LAMA2, LAMA3, LAMA5, LAMA4, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, CHAD, RELN, THBS1, COMP, THBS2, THBS3, THBS4, FN1, SPP1, VTN, TNC, TNN, TNR, TNXB, VWF, IBSP, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGA10, ITGA11, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, PDGFA, PDGFB, PDGFC, PDGFD, EGF, IGF1, VEGFA, VEGFB, PGF, VEGFC, VEGFD, HGF, PDGFRA, PDGFRB, IGF1R, KDR, EGFR, FLT1, FLT4, MET, ERBB2, SRC, ARHGAP35, ARHGAP5, RHOA, DIAPH1, ROCK1, ROCK2, MYL2, MYL5, MYL7, MYL9, MYL10, MYL12B, MYL12A, MYL11, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PPP1R12C, MYLK, MYLK2, MYLK3, MYLK4, PIP5K1C, PIP5K1A, PIP5K1B, ACTG1, ACTB, RASGRF1, CAPN2, ACTN1, ACTN4, TLN1, TLN2, FLNA, FLNC, FLNB, PXN, ILK, ZYX, VASP, VCL, PARVB, PARVA, PARVG, PDPK1, AKT1, AKT2, AKT3, GSK3B, CTNNB1, PRKCA, PRKCB, PRKCG, PTK2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PTEN, VAV3, VAV1, VAV2, RAC1, RAC2, RAC3, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, BUB1B-PAK6, CDC42, BCAR1, CRK, CRKL, DOCK1, RAPGEF1, RAP1A, RAP1B, MAPK8, MAPK10, MAPK9, JUN, BRAF, CAV1, CAV2, CAV3, FYN, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, RAF1, MAP2K1, MAPK1, MAPK3, ELK1, CCND1, CCND2, CCND3, BIRC2, BIRC3, XIAP, BAD, BCL2
## 72                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               CD44, SRC, CTTN, HCLS1, ERBB2, GRB2, VAV3, VAV1, VAV2, HRAS, KRAS, NRAS, RRAS, RRAS2, MRAS, BRAF, RAF1, ARAF, MAP2K1, MAP2K2, MAPK1, MAPK3, RAC1, IQGAP1, CDC42, ELK1, ESR1, CCND1, ACTG1, ACTB, FLNA, FLNC, FLNB, PAK1, TIAM1, ARHGEF1, RHOA, ROCK1, ROCK2, ANK1, ANK2, ANK3, GAB1, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, SLC9A1, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PPP1R12C, ARHGEF12, PLCE1, ITPR1, ITPR2, ITPR3, CAMK2A, CAMK2D, CAMK2B, CAMK2G, NANOG, NANOGP8, DDX5, DROSHA, STAT3, MIR21, TWIST1, TWIST2, MIR10A, MIR10B, HOXD10, DCN, IGF1, IGF1R, MTOR, PDPK1, RPS6KB1, RPS6KB2, EIF4B, RPS6, EGFR, CAV1, CAV2, CAV3, CD63, CDKN1A, CASP3, TGFB1, TLR2, TLR4, PDCD4, TNF, IL12B, ERBB3, ERBB4, MYC, CTNNB1, HIF1A, TFAP4, VEGFA, KDR, MET, CBL, TIMP3, THBS1, MMP2, MMP9, LUM, FASLG, FAS, MDM2, TP53, TGFB2, SMAD2, HPSE, HPSE2, SDC1, PLAU, PLAUR, COL1A1, COL1A2, ITGA2, ITGB1, VTN, ITGAV, ITGB3, FN1, ITGB5, HGF, WNT1, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, ITGA5, SDC2, EZR, RDX, MSN, SDC4, FGF2, FGFR1, FRS2, PTPN11, SOS1, SOS2, PLCG1, PLCG2, PRKCA, PRKCB, PRKCG, NUDT16L1, PXN, PTK2, HBEGF, GPC1, IGF2, GPC3, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, SHH, IHH, PTCH1, SMO, HSPG2, CTSL, PRKACA, PRKACB, PRKACG, MAPK11, MAPK12, MAPK13, MAPK14, HSPB2, PTPN6
## 91                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             POMC, ASIP, MC1R, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, EP300, MITF, WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, GNAO1, GNAQ, DVL3, DVL2, DVL1, GSK3B, CTNNB1, TCF7, TCF7L1, TCF7L2, LEF1, KITLG, KIT, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, TYR, TYRP1, DCT, EDN1, EDNRB, GNAI1, GNAI3, GNAI2, PLCB1, PLCB2, PLCB3, PLCB4, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, PRKCA, PRKCB, PRKCG
## 107                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  LIF, LIFR, IL6ST, JAK1, JAK2, JAK3, STAT3, KLF4, SOX2, MYC, GRB2, MAP2K1, MAP2K2, MAPK1, MAPK3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, TBX3, NANOG, NANOGP8, INHBA, INHBB, INHBC, INHBE, NODAL, ACVR1B, ACVR1C, ACVR2A, ACVR2B, SMAD2, SMAD3, BMP4, BMPR1A, BMPR1B, ACVR1, BMPR2, SMAD1, SMAD5, SMAD9, SMAD4, ID1, ID2, ID3, ID4, DUSP9, MAPK11, MAPK12, MAPK13, MAPK14, WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, DVL3, DVL2, DVL1, GSK3B, AXIN1, AXIN2, APC, APC2, CTNNB1, TCF3, ESRRB, TCF7, POU5F1, POU5F1B, FGF2, FGFR1, FGFR2, FGFR3, FGFR4, HRAS, KRAS, NRAS, RAF1, IGF1, IGF1R, HESX1, ZIC3, LEFTY1, LEFTY2, SKIL, SMARCAD1, KAT6A, SETDB1, JARID2, REST, RIF1, PCGF1, PCGF2, PCGF3, BMI1, COMMD3-BMI1, PCGF5, PCGF6, PAX6, MEIS1, HOXB1, HOXA1, HOXD1, LHX5, OTX1, NEUROG1, HAND1, DLX5, MYF5, ONECUT1, ISL1, ZFHX3, ESX1
## 109                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           ESR1, ESR2, NCOA1, NCOA3, FOS, JUN, SP1, CCND1, MYC, PGR, WNT1, WNT4, TNFSF11, ERBB2, FGF1, FGF2, FGF3, FGF4, FGF17, FGF6, FGF7, FGF8, FGF9, FGF10, FGF16, FGF5, FGF18, FGF20, FGF22, FGF19, FGF21, FGF23, FGFR1, IGF1, IGF1R, EGF, EGFR, KIT, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PTEN, AKT1, AKT2, AKT3, MTOR, RPS6KB1, RPS6KB2, JAG1, JAG2, DLL3, DLL1, DLL4, NOTCH1, NOTCH2, NOTCH3, NOTCH4, HES1, HES5, HEYL, HEY1, HEY2, FLT4, CDKN1A, NFKB2, WNT2, WNT2B, WNT3, WNT3A, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, LRP5, LRP6, DVL3, DVL2, DVL1, FRAT1, FRAT2, GSK3B, AXIN1, AXIN2, APC, APC2, CTNNB1, CSNK1A1L, CSNK1A1, TCF7, TCF7L1, TCF7L2, LEF1, TP53, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK, CDK4, CDK6, RB1, E2F1, E2F2, E2F3, BRCA1, BRCA2
## 110                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       CDX2, MUC2, CDH17, REG4, ABCB1, SHH, TP53, CDKN1A, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK, RARB, RXRA, RXRB, RXRG, WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, LRP5, LRP6, DVL3, DVL2, DVL1, FRAT1, FRAT2, GSK3B, AXIN1, AXIN2, APC, APC2, CTNNB1, CSNK1A1L, CSNK1A1, TCF7, TCF7L1, TCF7L2, LEF1, MYC, CCND1, TERT, TERC, EGF, EGFR, ERBB2, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MTOR, RPS6KB1, RPS6KB2, BCL2, MLH1, CDKN1B, CDK2, CCNE1, CCNE2, RB1, E2F1, E2F2, E2F3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD2, SMAD3, SMAD4, CDKN2B, CDH1, CTNNA3, CTNNA1, CTNNA2, JUP, HGF, MET, FGF1, FGF2, FGF3, FGF4, FGF17, FGF6, FGF7, FGF8, FGF9, FGF10, FGF16, FGF5, FGF18, FGF20, FGF22, FGF19, FGF21, FGF23, FGFR2, GAB1
## 120                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               CRH, CRHR1, CRHR2, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, MEN1, ASH2L, RBBP5, WDR5, WDR5B, KMT2A, KMT2D, CDKN2C, CDKN2B, CDKN2A, CDK4, CDK6, CCND1, RB1, E2F1, E2F2, E2F3, RASD1, GNAI1, GNAI3, GNAI2, AHR, AIPL1, AIP, ARNT, CDKN1B, CDK2, CCNE1, CCNE2, CDKN1A, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CAMK2A, CAMK2D, CAMK2B, CAMK2G, RAP1A, RAP1B, BRAF, MAP2K1, MAP2K2, MAPK1, MAPK3, NR4A1, EGFR, USP8, POMC, MC2R, MRAP, PDE8B, PDE8A, PDE11A, NR5A1, SP1, PBX1, CYP11B1, CYP17A1, STAR, NCEH1, ARMC5, AGT, AGTR1, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, KCNK2, CACNA1G, CACNA1H, CACNA1I, ORAI1, KCNA4, KCNK3, LDLR, SCARB1, CYP11A1, HSD3B1, HSD3B2, CYP21A2, FH, WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, DVL3, DVL2, DVL1, GSK3B, AXIN1, AXIN2, CTNNB1, APC, APC2, TCF7, TCF7L1, TCF7L2, LEF1
## 150                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             SLC7A5, SLC3A2, SLC38A9, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C2, ATP6V1C1, ATP6V1D, ATP6V1E2, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G3, ATP6V1G2, ATP6V1H, LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4, LAMTOR5, FLCN, FNIP1, FNIP2, RRAGA, RRAGB, RRAGC, RRAGD, SESN2, CASTOR1, CASTOR2, MIOS, SEH1L, WDR24, WDR59, SEC13, DEPDC5, NPRL2, NPRL3, SKP2, RNF152, RPTOR, AKT1S1, MTOR, DEPTOR, MLST8, TELO2, TTI1, CLIP1, GRB10, LPIN1, LPIN3, LPIN2, ULK1, ULK2, EIF4EBP1, EIF4E, EIF4E2, EIF4E1B, RPS6KB1, RPS6KB2, EIF4B, RPS6, STRADA, STRADB, STK11, CAB39, CAB39L, PRKAA1, PRKAA2, TSC1, TSC2, TBC1D7, RHEB, DDIT4, WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, LRP5, LRP6, DVL3, DVL2, DVL1, GSK3B, TNF, TNFRSF1A, IKBKB, INS, IGF1, INSR, IGF1R, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, IRS1, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, PTEN, PDPK1, AKT1, AKT2, AKT3, CHUK, MAPKAP1, RICTOR, PRR5, PRR5L, RHOA, PRKCA, PRKCB, PRKCG, SGK1
## 154                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             TGFA, EGFR, IGF2, IGF1R, PLCG1, PLCG2, PRKCA, PRKCB, PRKCG, ELK1, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PTEN, AKT1, AKT2, AKT3, MTOR, RPS6KB1, RPS6KB2, BAD, BCL2L1, MYC, RB1, E2F1, E2F2, E2F3, TERT, TERC, TP53, CDKN1A, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK, CDKN2A, CDK4, CDK6, CCND1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD2, SMAD3, SMAD4, WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, LRP5, LRP6, DVL3, DVL2, DVL1, FRAT1, FRAT2, GSK3B, AXIN1, AXIN2, APC, APC2, CTNNB1, CSNK1A1L, CSNK1A1, TCF7, TCF7L1, TCF7L2, LEF1, KEAP1, NFE2L2, HMOX1, NQO1, GSTA5, GSTA2, GSTA4, GSTO2, GSTM4, GSTT2, GSTT1, GSTM3, MGST1, MGST3, GSTM1, GSTM5, MGST2, GSTA1, GSTM2, GSTA3, GSTO1, GSTT2B, GSTP1, TXNRD1, TXNRD3, TXNRD2, HGF, MET, GAB1, ACTG1, ACTB, ACTL6A, ACTL6B, SMARCD1, SMARCD2, SMARCD3, PHF10, DPF1, DPF3, ARID1B, ARID1A, SMARCE1, SMARCB1, SMARCC1, SMARCC2, SMARCA2, SMARCA4, ARID2, PBRM1, BRD7
## 77                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 INS, IGF1R, IRS1, IRS2, IRS4, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PDPK1, AKT1, AKT2, AKT3, PTEN, HRAS, KRAS, NRAS, MRAS, RRAS, RRAS2, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, HIF1A, DDIT4, TSC2, TSC1, BNIP3, RHEB, RPTOR, DEPTOR, MTOR, AKT1S1, MLST8, RPS6KB1, RPS6KB2, IGBP1, PPP2CA, PPP2CB, ULK1, ULK2, ATG13, ATG101, RB1CC1, ATG2A, ATG2B, WIPI2, WIPI1, ATG9B, ATG9A, SUPT20H, SMCR8, WDR41, C9orf72, RAB8A, RAB39B, SQSTM1, TBK1, TANK, RAB1A, RRAGA, RRAGB, RRAGC, RRAGD, STK11, PRKAA1, PRKAA2, PRKACA, PRKACB, PRKACG, PRKCD, MAPK8, MAPK10, MAPK9, BCL2, BCL2L1, BAD, BECN1, BECN2, NRBF2, PIK3R4, PIK3C3, ATG14, AMBRA1, TRAF6, TP53INP2, VMP1, STX17, UVRAG, SH3GLB1, RUBCN, CAMKK2, MAP3K7, ERN1, ITPR1, DAPK1, DAPK3, DAPK2, HMGB1, PRAP1, EIF2AK3, EIF2AK4, EIF2S1, MTMR3, MTMR4, MTMR14, ZFYVE1, ATG12, ATG5, ATG16L1, ATG16L2, ATG7, ATG10, ATG3, CFLAR, RAB33B, PRKCQ, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3C, MAP1LC3B, MAP1LC3A, MAP1LC3B2, ATG4A, ATG4B, ATG4C, ATG4D, LAMP1, LAMP2, RAB7A, RAB7B, VAMP8, SNAP29, CTSD, CTSL, CTSB
## 78                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   CHRNA7, ARRB1, ARRB2, SRC, RAF1, RB1, E2F1, BIRC5, XIAP, CDC6, CDC25A, JAK2, STAT3, IKBKE, CCND1, CHRNA4, CHRNB2, CHRNA3, CHRNB4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CACNA1B, CACNA1A, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MTOR, NFKB1, RELA, HRAS, KRAS, NRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, FOS, JUN, MYC, BCL2, PRKCA, PRKCB, PRKCG, VEGFA, FGF2, ADRB1, ADRB2, ADRB3, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, GNAI1, GNAI3, GNAI2, BAD, CHRNA9, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, ESR1, ESR2, VDR, CCND3, EGFR, GRB2, SOS1, SOS2, EIF4EBP1, RPS6KB1, RPS6KB2, PAQR7, PAQR8, PAQR5, PGR, TNFSF11, STAT5A, STAT5B, BCL6, KLF5, KLF4, WNT1, NOTCH2, JAG1, MIR141, MIR29A, MIR29B1, MIR29B2, MIR29C, AR, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, EGF, FGF3, FGF4, FGF17, FGF6, FGF7, FGF8, FGF9, FGF10, FGF16, FGF5, FGF18, FGF20, FGF22, DLL3, DLL1, DLL4, PTGES3, AIPL1, AIP, AHR, HSP90AA1, HSP90AB1, HSP90B1, KPNA1, KPNA2, KPNA7, KPNA3, KPNA4, KPNA6, KPNA5, KPNB1, ARNT, CYP1A1, CYP1B1, EPHX1, EPHX2, EPHX3, EPHX4, GSTA5, GSTA2, GSTA4, GSTO2, GSTM4, GSTT2, GSTT1, GSTM3, MGST1, MGST3, GSTM1, GSTM5, MGST2, GSTA1, GSTM2, GSTA3, GSTO1, GSTT2B, UGT2A1, UGT2A3, UGT2B17, UGT2B11, UGT2B28, UGT1A6, UGT1A4, UGT1A1, UGT1A3, UGT2B10, UGT1A9, UGT2B7, UGT1A10, UGT1A8, UGT1A5, UGT2B15, UGT1A7, UGT2B4, UGT2A2, CYP2B6, NR1I3, RXRA, RXRB, RXRG, CYP3A4, CYP1A2, PPARA
## 80                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      SLC2A1, SLC2A2, GCK, PKM, PDHA2, PDHA1, PDHB, PDK1, TP53, SCO2, SLC1A5, SIRT3, SLC16A3, SIRT6, MYC, HIF1A, KIT, MET, RET, EGFR, ERBB2, NTRK1, NTRK3, PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3, FLT3, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, GLS2, GLS, G6PD, HK3, HK1, HK2, HKDC1, PFKM, PFKP, PFKL, PGAM1, PGAM2, PGAM4, LDHAL6A, LDHAL6B, LDHA, LDHB, LDHC, IDH1, IDH2, TIGAR, PTEN, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MTOR, SLC7A5
## 142                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 IL6, IL6R, STAT3, TLR4, IFNG, IFNGR1, IFNGR2, RELA, NFKB1, INS, EGF, IGF1, INSR, EGFR, IGF1R, ERBB2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MTOR, EIF4EBP1, EIF4E, EIF4E2, EIF4E1B, RPS6KB1, RPS6KB2, RPS6, HIF1A, VHL, RBX1, ELOC, ELOB, CUL2, EGLN1, EGLN3, EGLN2, ARNT, CREBBP, EP300, CYBB, PLCG1, PLCG2, PRKCA, PRKCB, PRKCG, CAMK2A, CAMK2D, CAMK2B, CAMK2G, TIMP1, LTBR, EPO, TF, TFRC, VEGFA, FLT1, SERPINE1, ANGPT1, ANGPT2, ANGPT4, TEK, EDN1, NOS2, NOS3, HMOX1, NPPA, SLC2A1, PDK1, HK3, HK1, HK2, HKDC1, PFKM, PFKP, PFKL, GAPDH, ALDOC, ALDOA, ALDOB, ENO3, ENO2, ENO1, ENO4, PGK2, PGK1, PFKFB3, LDHAL6A, LDHAL6B, LDHA, LDHB, LDHC, BCL2, CDKN1A, CDKN1B, PDHA2, PDHA1, PDHB
## 163                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     AMY1C, AMY2A, AMY1A, AMY2B, AMY1B, LCT, MGAM, MGAM2, SI, SLC5A1, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, FXYD2, SLC2A2, HK3, HK1, HK2, HKDC1, SLC37A4, G6PC1, G6PC2, G6PC3, SLC2A5, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, AKT1, AKT2, AKT3, CACNA1D, PRKCB, TAS1R2, TAS1R3, GNAT3, PLCB1, PLCB2, PLCB3, PLCB4
## 84                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            BCL2L13, EIF2AK3, ATF4, MAPK8, MAPK10, MAPK9, JUN, PINK1, TOMM7, PRKN, UBA52, RPS27A, UBB, UBC, MFN1, MFN2, RHOT1, RHOT2, USP8, USP15, USP30, TAX1BP1, SQSTM1, CALCOCO2, OPTN, NBR1, TBK1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3C, MAP1LC3B, MAP1LC3A, MAP1LC3B2, AMBRA1, ATG5, ATG9B, ATG9A, MITF, TFEB, TFE3, BECN1, BECN2, BCL2L1, PGAM5, CSNK2A1, CSNK2A2, CSNK2A3, CSNK2B, SRC, ULK1, FUNDC1, HIF1A, E2F1, RELA, BNIP3, HRAS, KRAS, NRAS, MRAS, RRAS, RRAS2, TP53, BNIP3L, FOXO3, CITED2, SP1, TBC1D15, TBC1D17, RAB7A, RAB7B, FIS1
## 87                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD2, SMAD3, CDKN2B, CDK4, CDK6, CCND1, CCND2, CCND3, RB1, RBL1, RBL2, E2F1, E2F2, E2F3, E2F4, E2F5, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, FOXO1, FOXO3, CDKN1A, CDK2, CCNE1, CCNE2, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G, HLA-E, KIR2DL4, KRAS, NRAS, RRAS, RRAS2, MRAS, HRAS, AKT1, AKT2, AKT3, TSC1, TSC2, RHEB, MTOR, PTEN, SIRT1, CCNA2, CCNA1, MYBL2, LIN9, LIN37, LIN52, LIN54, RBBP4, FOXM1, MYC, CDKN2A, MDM2, TP53, RASSF5, BTRC, FBXW11, HIPK3, HIPK1, HIPK2, HIPK4, PPP1CA, PPP1CB, PPP1CC, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, ETS1, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, GADD45A, GADD45B, GADD45G, CDK1, CCNB1, CCNB2, CCNB3, MRE11, RAD50, NBN, ATM, CHEK2, RAD9A, RAD9B, RAD1, HUS1, ATR, CHEK1, CDC25A, SQSTM1, GATA4, TRAF3IP2, NFKB1, RELA, IL1A, IL6, CXCL8, IGFBP3, SERPINE1, EIF4EBP1, MAPKAPK2, ZFP36L1, ZFP36L2, CACNA1D, TRPV4, TRPM7, CAPN1, CAPN2, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, NFATC4, ITPR1, ITPR2, ITPR3, SLC25A4, SLC25A5, SLC25A6, SLC25A31, PPID, VDAC1, VDAC2, VDAC3, MCU
## 88                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  HIF1A, EGF, EGFR, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, FOS, JUN, EML4, ALK, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, PTEN, AKT1, AKT2, AKT3, MTOR, RPS6KB1, RPS6KB2, CHUK, IKBKB, IKBKG, NFKBIA, NFKBIB, NFKBIE, NFKB1, RELA, IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1, STAT3, TLR2, TLR4, TLR9, TIRAP, MYD88, TRAF6, NFATC1, NFATC2, NFATC3, TICAM1, TICAM2, CD274, PDCD1, PTPN6, PTPN11, BATF3, BATF, BATF2, CSNK2A1, CSNK2A2, CSNK2A3, CSNK2B, CD4, LCK, CD3E, CD3G, CD247, CD3D, ZAP70, MAP3K3, MAP2K3, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, LAT, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, RASGRP1, CD28, PRKCQ
## 96                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       DLL3, DLL1, DLL4, NOTCH3, MAML3, MAML2, MAML1, RBPJL, RBPJ, NFKB1, RELA, IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1, IL12A, IL12B, IL12RB1, IL12RB2, TYK2, STAT4, TBX21, RUNX3, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, CD4, LCK, CD3E, CD3G, CD247, CD3D, ZAP70, LAT, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, PRKCQ, CHUK, IKBKB, IKBKG, NFKBIA, NFKBIB, NFKBIE, MAPK1, MAPK3, FOS, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK10, MAPK9, JUN, IL2, IL2RA, IL2RB, IL2RG, JAK3, STAT5A, STAT5B, IL4, IL4R, STAT6, GATA3, IL5, IL13, MAF, JAG1, JAG2, NOTCH1, NOTCH2
## 103                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      CD3D, CD3E, CD3G, CD247, CD4, CD8A, CD8B, CD8B2, PTPRC, LCK, FYN, ZAP70, LCP2, LAT, ITK, TEC, NCK1, NCK2, VAV3, VAV1, VAV2, GRAP2, GRB2, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, BUB1B-PAK6, RHOA, CDC42, DLG1, MAPK11, MAPK12, MAPK13, MAPK14, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, SOS1, SOS2, RASGRP1, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, FOS, JUN, PRKCQ, CARD11, BCL10, MALT1, MAP3K7, MAP2K7, MAPK8, MAPK10, MAPK9, CHUK, IKBKB, IKBKG, NFKB1, RELA, NFKBIA, NFKBIB, NFKBIE, CD28, ICOS, CD40LG, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, PDPK1, AKT1, AKT2, AKT3, MAP3K8, MAP3K14, GSK3B, PDCD1, CTLA4, PTPN6, CBLB, IL2, IL4, IL5, IL10, IFNG, CSF2, TNF, CDK4
## 132                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        IL1B, IL1R1, IL1RAP, MAPK11, MAPK12, MAPK13, MAPK14, MTOR, IRF4, TGFB1, TGFBR1, TGFBR2, SMAD2, SMAD3, SMAD4, IL21, IL21R, IL2RG, JAK1, JAK3, IL6, IL6R, IL6ST, JAK2, IL23A, IL23R, IL12RB1, TYK2, STAT3, RORC, RORA, HIF1A, HSP90AA1, HSP90AB1, AHR, IL17A, IL17F, IL22, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, CD4, LCK, CD3E, CD3G, CD247, CD3D, ZAP70, LAT, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC1, NFATC2, NFATC3, PRKCQ, CHUK, IKBKB, IKBKG, NFKBIA, NFKBIB, NFKBIE, NFKB1, RELA, MAPK1, MAPK3, FOS, MAPK8, MAPK10, MAPK9, JUN, IL4, IL4R, STAT6, GATA3, RUNX1, IL27, EBI3, IL27RA, IFNG, IFNGR1, IFNGR2, STAT1, TBX21, IL2, IL2RA, IL2RB, STAT5A, STAT5B, FOXP3, RARA, RXRA, RXRB, RXRG
## 90                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  TBXA2R, F2, F2R, F2RL3, GNA13, ARHGEF1, ARHGEF12, RHOA, ROCK1, ROCK2, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, MYL12B, MYL12A, P2RX1, ORAI1, ITPR1, ITPR2, ITPR3, STIM1, MYLK, MYLK2, MYLK3, MYLK4, P2RY1, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, PRKCZ, PRKCI, RASGRP1, RASGRP2, RAP1A, RAP1B, APBB1IP, TLN1, TLN2, ITGA2B, ITGB3, FERMT3, FGA, FGB, FGG, P2RY12, GNAI1, GNAI3, GNAI2, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PTGIR, GNAS, PIK3CG, PIK3R5, PIK3R6, PRKACA, PRKACB, PRKACG, VASP, ACTG1, ACTB, SRC, ARHGAP35, FCGR2A, SYK, COL1A1, COL1A2, COL3A1, GP6, FCER1G, LYN, FYN, ITGA2, ITGB1, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, LCP2, PLCG2, BTK, VWF, GP5, GP1BA, GP1BB, GP9, AKT1, AKT2, AKT3, NOS3, GUCY1A2, GUCY1A1, GUCY1B1, PRKG1, PRKG2, MAPK11, MAPK12, MAPK13, MAPK14, MAPK1, MAPK3, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PTGS1, TBXAS1, SNAP23, VAMP8
## 92                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              TH, DDC, SLC18A1, SLC18A2, MAOB, MAOA, SLC6A3, DRD1, GNAS, GRM2, GRM3, GNAI1, GNAI3, GNAI2, DRD2, ADCY5, PRKACA, PRKACB, PRKACG, GPSM1, RGS9, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, PDYN, BDNF, JUN, FOSB, NFKB1, RELA, CDK5, CDK5R1, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, DLG4, PPP1R1B, GRIA2
## 116                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          TH, DDC, SLC18A1, SLC18A2, MAOB, MAOA, SLC6A3, CACNA1C, CACNA1D, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRIA1, GRIA2, GRIA3, GRIA4, DRD1, PRKCA, PRKCB, PRKCG, STX1A, CAMK2A, CAMK2D, CAMK2B, CAMK2G, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK4, GNAS, ADCY5, PRKACA, PRKACB, PRKACG, PPP1R1B, PPP1CA, PPP1CB, PPP1CC, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, PDYN, ARC, FOS, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, JUN, FOSB, SIRT1, HDAC1, HDAC2
## 145                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   TH, DDC, SLC18A1, SLC18A2, MAOB, MAOA, SLC6A3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, HDAC10, HDAC11, H2AX, H2AC20, H2AC12, H2AC1, H2AC25, H2AB3, H2AC8, H2AC4, MACROH2A2, MACROH2A1, H2AC19, H2AJ, H2AB1, H2AC17, H2AC18, H2AC11, H2AC21, H2AZ2, H2AC7, H2AZ1, H2AC15, H2AC6, H2AC13, H2AC14, H2AC16, H2AB2, H2BC15, H2BC9, H2BC14, H2BW1, H2BC1, H2BC18, H2BC17, H2BC3, H2BC8, H2BC13, H2BC4, H2BC5, H2BC6, H2BC10, H2BC21, H2BC11, H2BC12, H2BC26, H2BC7, H2BW2, H2BK1, H2BC12L, H3-5, H3-3B, H3C4, H3C3, H3C1, H3-3A, H3-4, H3C14, H3C15, H3C13, H3C6, H3C11, H3C8, H3C12, H3C10, H3C2, H3C7, H4C16, H4C15, H4C9, H4C4, H4C6, H4C12, H4C11, H4C3, H4C8, H4C2, H4C5, H4C13, H4C14, H4C1, H4C7, HAT1, DRD1, GNAS, DRD2, GNAI1, GNAI3, GNAI2, GNAO1, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, SLC29A3, SLC29A1, SLC29A2, ADORA2A, ADORA2B, ADCY5, PRKACA, PRKACB, PRKACG, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, CRH, NPY, BDNF, NTRK2, SHC1, SHC2, SHC3, SHC4, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAPK1, MAPK3, PDYN, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMKK1, CAMKK2, CAMK4, FOSB, PPP1R1B, PPP1CA, PPP1CB, PPP1CC, PKIA
## 93                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               ADRB1, ADRB2, ADRB3, ADCYAP1, ADCYAP1R1, AQP1, PTGER2, PTGER4, GNAS, ADCY5, ADCY6, PRKACA, PRKACB, PRKACG, CREB1, KCNMA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B, REN, ADORA1, GNAI1, GNAI3, GNAI2, ORAI1, CLCA1, CLCA2, CLCA4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, KCNJ2, EDN1, EDN2, EDN3, EDNRA, AGTR1, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, GUCY1A2, GUCY1A1, GUCY1B1, NPPA, NPR1, PRKG2, CTSB, AGT, ACE
## 97                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, NOS1, MAPK1, MAPK3, RPS6KA5, CREB1, ITPR1, ITPR3, RYR1, RYR2, RYR3, NOS1AP, RASD1, GNAI1, GNAI3, GNAI2, GNAO1, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, GRIA1, GRIA2, GRIA3, GRIA4, CACNA1G, CACNA1H, CACNA1I, ADCYAP1, ADCYAP1R1, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADCY10, PRKACA, PRKACB, PRKACG, GUCY1A2, GUCY1A1, GUCY1B1, PRKG1, PRKG2, CACNA1C, CACNA1D, MTNR1B, MTNR1A, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, PRKCB, PRKCG, KCNJ3, KCNJ5, KCNJ6, KCNJ9, PER1, PER2, PER3, FOS
## 122                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      SLC38A1, SLC38A2, GLS2, GLS, SLC17A6, SLC17A8, SLC17A7, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, DLG4, DLGAP1, SHANK3, SHANK1, SHANK2, TRPC1, GRM1, GRM5, HOMER1, HOMER2, HOMER3, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, PRKCB, PRKCG, ITPR1, ITPR2, ITPR3, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PLD1, PLD2, MAPK1, MAPK3, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, GRM2, GRM3, GRM4, GRM6, GRM7, GRM8, GNAI1, GNAI3, GNAI2, GNAO1, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, GRK2, GRK3, KCNJ3, CACNA1A, SLC1A2, SLC1A7, SLC1A1, SLC1A6, CACNA1C, CACNA1D, SLC1A3, GLUL, SLC38A3
## 124                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   GRIA1, GRIA2, ADCY1, ADCY8, PRKACA, PRKACB, PRKACG, PPP1R1A, PPP1CA, PPP1CB, PPP1CC, CAMK2A, CAMK2D, CAMK2B, CAMK2G, RAPGEF3, RAP1A, RAP1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, CACNA1C, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CREBBP, EP300, ATF4, CAMK4, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, ITPR1, ITPR2, ITPR3, PRKCA, PRKCB, PRKCG, GRM1, GRM5, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4
## 129                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         ADRB1, ADRB2, ADRB3, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, VAMP2, ADRA1A, ADRA1B, ADRA1D, CHRM3, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, PRKCB, PRKCG, ITPR1, ITPR2, ITPR3, RYR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, NOS1, GUCY1A2, GUCY1A1, GUCY1B1, PRKG1, PRKG2, CD38, BST1, BEST2, AQP5, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, FXYD2, ATP2B1, ATP2B3, ATP2B4, ATP2B2, SLC12A2, KCNN4, KCNMA1, SLC4A2, SLC9A1, TRPV6, MUC5B, MUC7, AMY1C, AMY2A, AMY1A, AMY2B, AMY1B, PRH2, PRH1, PRB1, PRB2, DMBT1, CST1, CST2, CST3, CST4, CST5, HTN1, HTN3, STATH, LYZ, LPO, CAMP
## 139                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GJA1, GJD2, LPAR1, GNAI1, GNAI3, GNAI2, PDGFA, PDGFB, PDGFC, PDGFD, EGF, PDGFRA, PDGFRB, EGFR, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, SRC, MAP3K2, MAP2K5, MAPK7, TUBA1B, TUBA4A, TUBA3C, TUBA1A, TUBA1C, TUBA8, TUBA3E, TUBA3D, TUBAL3, TUBB6, TUBB, TUBB1, TUBB2A, TUBB3, TUBB4A, TUBB8, TUBB2B, TUBB4B, CSNK1D, CDK1, TJP1, ADRB1, DRD1, GNAS, DRD2, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, HTR2A, HTR2B, HTR2C, GRM1, GRM5, GNA11, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, PRKCA, PRKCB, PRKCG, GUCY1A2, GUCY1A1, GUCY1B1, PRKG1, PRKG2
## 141                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             NOS1, GUCY1A2, GUCY1A1, GUCY1B1, PRKG1, PRKG2, PPP1R17, PPP2R1B, PPP2R1A, PPP2CA, PPP2CB, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, GRID2, GRM1, GNAI1, GNAI3, GNAI2, GNAO1, GNAZ, GNAS, GNA12, GNA13, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PRKCA, PRKCB, PRKCG, GNAQ, GNA11, PLCB1, PLCB2, PLCB3, PLCB4, GRIA1, GRIA2, GRIA3, LYN, CACNA1A, ITPR1, ITPR2, ITPR3, RYR1, CRH, CRHR1, IGF1, IGF1R
## 149                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               TPH2, TPH1, DDC, SLC18A1, SLC18A2, CACNA1C, CACNA1D, CACNA1F, CACNA1S, HTR2A, HTR2B, HTR2C, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, PRKCA, PRKCB, PRKCG, MAPK1, MAPK3, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2D7, CYP2J2, CYP4X1, ALOX5, ALOX12, ALOX12B, ALOX15, ALOX15B, PTGS1, PTGS2, HTR3A, HTR3E, HTR3D, HTR3C, HTR3B, HTR4, HTR6, HTR7, GNAS, ADCY5, PRKACA, PRKACB, PRKACG, KCNN2, KCND2, GABRB1, GABRB3, GABRB2, RAPGEF3, APP, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR5A, GNAI1, GNAI3, GNAI2, GNAO1, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, CASP3, DUSP1, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, CACNA1A, CACNA1B, KCNJ3, KCNJ6, KCNJ9, KCNJ5, TRPC1, SLC6A4, MAOB, MAOA
## 151                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   CHRM3, GAST, CCKBR, GNAQ, PLCB1, PLCB2, PLCB3, PLCB4, PRKCA, PRKCB, PRKCG, EZR, ACTG1, ACTB, ITPR1, ITPR2, ITPR3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, MYLK, MYLK2, MYLK3, MYLK4, HRH2, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, SST, SSTR2, GNAI1, GNAI3, GNAI2, PRKACA, PRKACB, PRKACG, ATP4A, ATP4B, KCNE2, KCNQ1, KCNJ1, KCNJ2, KCNJ10, KCNJ15, KCNJ16, CFTR, KCNK2, KCNK10, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, SLC9A1, SLC9A4, CA2, SLC26A7, SLC4A2
## 157                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             ADRA1A, ADRA1B, ADRA1D, AGT, AGTR1, EDN1, EDN2, EDN3, EDNRA, AVP, AVPR1A, AVPR1B, GNAQ, GNA11, PLA2G10, PLA2G2D, PLA2G2E, PLA2G3, PLA2G2F, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G5, PLA2G2A, PLA2G2C, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, PLA2G6, KCNMA1, KCNU1, KCNMB1, KCNMB2, KCNMB3, KCNMB4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, MYLK, MYLK2, MYLK3, MYLK4, MYL6B, MYL6, MYL9, MYH9, MYH10, MYH11, MYH14, PLCB1, PLCB2, PLCB3, PLCB4, ITPR1, ITPR2, ITPR3, PRKCA, PRKCB, PRKCG, PRKCD, PRKCE, PRKCH, PRKCQ, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, CALD1, ACTA2, ACTG2, PPP1R14A, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PPP1R12C, GNA12, GNA13, ARHGEF12, ARHGEF1, ARHGEF11, RHOA, ROCK1, ROCK2, ADORA2A, ADORA2B, PTGIR, CALCA, CALCB, ADM, ADM2, CALCRL, RAMP1, RAMP2, RAMP3, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, NPPA, NPPB, NPR1, NPPC, NPR2, PRKG1, IRAG1, GUCY1A2, GUCY1A1, GUCY1B1
## 94                                                                                                                                                                                                                                                                                                                                                                                                                                                 SLC8A1, SLC8A2, SLC8A3, ATP2B1, ATP2B3, ATP2B4, ATP2B2, CHRM1, CHRM3, CHRM5, ADORA2A, ADORA2B, ADRB1, ADRB2, ADRB3, DRD1, DRD5, HRH2, HTR4, HTR5A, HTR6, HTR7, GNAS, GNAL, ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, PLN, ATP2A1, ATP2A3, ATP2A2, HRC, STIM1, STIM2, ORAI1, ORAI2, ORAI3, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CACNA1A, CACNA1B, CACNA1E, CACNA1G, CACNA1H, CACNA1I, CHRNA7, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RX6, GRIN1, GRIN2A, GRIN2C, GRIN2D, RYR1, RYR2, RYR3, TRDN, CASQ1, CASQ2, ASPH, CYSLTR1, CYSLTR2, CHRM2, ADRA1A, ADRA1B, ADRA1D, AGTR1, EDNRA, EDNRB, F2R, GRM1, GRM5, GRPR, HRH1, HTR2A, HTR2B, HTR2C, LHCGR, NTSR1, OXTR, AVPR1A, AVPR1B, LTB4R2, PTAFR, PTGER1, PTGER3, PTGFR, BDKRB1, BDKRB2, TACR1, TACR2, TACR3, TBXA2R, TRHR, CCKAR, CCKBR, CXCR4, GNAQ, GNA11, GNA14, GNA15, EGF, PDGFA, PDGFB, PDGFC, PDGFD, FGF1, FGF2, FGF3, FGF4, FGF17, FGF6, FGF7, FGF8, FGF9, FGF10, FGF16, FGF5, FGF18, FGF20, FGF22, FGF19, FGF21, FGF23, VEGFA, VEGFB, VEGFC, VEGFD, NGF, HGF, MST1, GDNF, EGFR, ERBB2, ERBB3, ERBB4, PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT4, KDR, NTRK1, NTRK2, NTRK3, MET, MST1R, RET, IGH, PLCD1, PLCD3, PLCD4, PLCB1, PLCB2, PLCB3, PLCB4, PLCG1, PLCG2, PLCE1, PLCZ1, ITPR1, ITPR2, ITPR3, CD38, TPCN1, TPCN2, MCOLN1, MCOLN2, MCOLN3, SPHK1, SPHK2, MCU, VDAC1, VDAC2, VDAC3, SLC25A4, SLC25A5, SLC25A6, SLC25A31, PPIF, TNNC1, TNNC2, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, PHKG1, PHKG2, PHKB, PHKA2, PHKA1, MYLK, MYLK2, MYLK3, MYLK4, CAMK1D, CAMK1G, CAMK1, CAMK2A, CAMK2D, CAMK2B, CAMK2G, CAMK4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NOS1, NOS2, NOS3, PDE1A, PDE1B, PDE1C, PTK2B, ITPKB, ITPKA, ITPKC, PRKCA, PRKCB, PRKCG
## 104                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 HSP90AA1, HSP90AB1, HSP90B1, NOS3, CAV1, CAV2, CAV3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, GPC1, SDC1, SDC2, SDC4, TRPV4, KEAP1, NFE2L2, HMOX1, GSTA5, GSTA2, GSTA4, GSTO2, GSTM4, GSTT2, GSTT1, GSTM3, MGST1, MGST3, GSTM1, GSTM5, MGST2, GSTA1, GSTM2, GSTA3, GSTO1, GSTT2B, GSTP1, NQO1, SQSTM1, TXN, TXN2, NPPC, ASS1, THBD, PLAT, CDH5, KDR, CTNNB1, PRKAA1, PRKAA2, PECAM1, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, MAP2K5, MAPK7, MEF2A, MEF2C, KLF2, ITGA2B, ITGAV, ITGB3, SRC, PTK2, ARHGEF2, RHOA, ACTG1, ACTB, DUSP1, MIR10A, TNFRSF1A, IL1R1, IL1R2, MAP3K7, IKBKG, CHUK, IKBKB, NFKB1, RELA, MAP3K5, MAP2K4, MAP2K7, MAPK8, MAPK10, MAPK9, MAP2K6, MAPK11, MAPK12, MAPK13, MAPK14, FOS, JUN, MMP2, MMP9, CTSL, CCL2, VCAM1, ICAM1, SELE, TNF, IL1A, IL1B, IFNG, PDGFA, PDGFB, EDN1, VEGFA, BMP4, BMPR2, ACVR2A, ACVR2B, ACVR1, BMPR1A, BMPR1B, NOX1, CYBA, NCF1, NCF2, RAC1, RAC2, RAC3, PRKCZ, PIAS4, TP53, SUMO3, SUMO2, SUMO1, SUMO4, BCL2
## 105                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          FGFR3, HRAS, KRAS, NRAS, ARAF, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, RPS6KA5, MYC, RASSF1, DAPK1, DAPK3, DAPK2, CDKN2A, MDM2, TP53, CDKN1A, CCND1, CDK4, RB1, E2F1, E2F2, E2F3, THBS1, HBEGF, MMP2, MMP9, UPK3A, SRC, EGF, ERBB2, EGFR, TYMP, VEGFA, MMP1, CXCL8, CDH1
## 159                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 RET, CCDC6, NCOA4, NTRK1, TPM3, TPR, TFG, HRAS, NRAS, KRAS, BRAF, MAP2K1, MAP2K2, MAPK1, MAPK3, PAX8, PPARG, RXRA, RXRB, RXRG, TP53, CDKN1A, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK, CDH1, CTNNB1, TCF7, TCF7L1, TCF7L2, LEF1, MYC, CCND1
## 114                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  TNF, TNFRSF1A, TRADD, TRAF2, TRAF5, RIPK1, BIRC2, BIRC3, XIAP, RBCK1, RNF31, SHARPIN, SPATA2L, SPATA2, CYLD, FADD, CASP8, CFLAR, RIPK3, CYBB, CAMK2A, CAMK2D, CAMK2B, CAMK2G, SLC25A4, SLC25A5, SLC25A6, SLC25A31, PPID, VDAC1, VDAC2, VDAC3, GLUD2, GLUD1, GLUL, PYGL, PYGM, PYGB, MAPK8, MAPK10, MAPK9, FTH1, FTL, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, ALOX15, CAPN1, CAPN2, SMPD1, MLKL, PGAM5, DNM1L, NLRP3, PYCARD, CASP1, IL1B, CHMP2A, CHMP2B, CHMP3, RNF103-CHMP3, CHMP4B, CHMP4A, CHMP4C, CHMP6, VPS4B, VPS4A, CHMP1B, CHMP1A, CHMP5, CHMP7, TRPM7, IL1A, IL33, HMGB1, TNFSF10, TNFRSF10A, TNFRSF10B, FASLG, FAS, FAF1, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNG, IFNAR1, IFNAR2, IFNGR1, IFNGR2, JAK1, JAK2, JAK3, TYK2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, IRF9, EIF2AK2, TLR4, TICAM2, TICAM1, TLR3, ZBP1, USP21, SQSTM1, HSP90AA1, HSP90AB1, TNFAIP3, PARP1, BID, BAX, AIFM1, H2AX, H2AC20, H2AC12, H2AC1, H2AC25, H2AB3, H2AC8, H2AC4, MACROH2A2, MACROH2A1, H2AC19, H2AJ, H2AB1, H2AC17, H2AC18, H2AC11, H2AC21, H2AZ2, H2AC7, H2AZ1, H2AC15, H2AC6, H2AC13, H2AC14, H2AC16, H2AB2, PPIA, BCL2
## 117                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        TNFRSF1A, FADD, CASP8, CASP7, CASP3, BID, BCL2L11, PMAIP1, BBC3, BCL2, BCL2L1, BAX, BAK1, CYCS, APAF1, CASP9, DIABLO, HTRA2, SEPTIN4, BIRC2, BIRC3, XIAP, BIRC5, MAPK8, MAPK10, MAPK9, BOK, BIRC7, NGFR, BECN1, BECN2, BIRC6
## 118                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              EGF, PDGFA, PDGFB, PDGFC, PDGFD, KITLG, INS, EGFR, PDGFRA, PDGFRB, KIT, INSR, GRB2, GAB1, GAB2, SHC1, SHC2, SHC3, SHC4, PTPN11, SOS1, SOS2, HRAS, KRAS, NRAS, MRAS, RRAS, RRAS2, RALGDS, RALA, RALB, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, TSC1, TSC2, RHEB, MTOR, RHOA, ARF1, ARF6, PLCG1, PLCG2, IGH, FCER1A, MS4A2, FCER1G, FYN, SYK, PRKCA, PLD1, PLD2, PLA2G4E, PLA2G4A, JMJD7-PLA2G4B, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4F, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT5, SPHK1, SPHK2, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PIP5K1C, PIP5K1A, PIP5K1B, DGKZ, DGKD, DGKI, DGKA, DGKE, DGKB, DGKH, DGKG, DGKQ, DGKK, PLPP1, PLPP3, PLPP2, F2, AGT, AVP, CXCL8, AGTR1, F2R, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, AVPR1A, AVPR1B, AVPR2, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, LPAR6, PTGFR, CXCR1, CXCR2, PLCB1, PLCB2, PLCB3, PLCB4, GNA12, PTK2B, GNA13, PIK3CG, PIK3R5, PIK3R6, CYTH3, CYTH4, CYTH2, CYTH1, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, RAPGEF3, RAPGEF4, DNM1, DNM3, DNM2
## 123                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 CRB3, CLDN4, CLDN3, CLDN7, CLDN19, CLDN16, CLDN14, CLDN15, CLDN17, CLDN20, CLDN11, CLDN18, CLDN22, CLDN5, CLDN10, CLDN8, CLDN6, CLDN2, CLDN1, CLDN9, CLDN23, CLDN34, CLDN25, CLDN24, OCLN, F11R, JAM2, JAM3, BVES, CDC42, PARD6A, PARD6G, PARD6B, PALS1, MPP4, TJP3, PATJ, MPDZ, PRKCZ, PRKCI, AMOT, AMOTL1, AMOTL2, ARHGAP17, RAC1, NF2, LLGL2, LLGL1, DLG1, SCRIB, PPP2CA, PPP2CB, PPP2R1B, PPP2R1A, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, PARD3, TIAM1, TJP1, TJAP1, DLG2, DLG3, NEDD4, NEDD4L, CGN, CGNL1, ARHGEF2, RHOA, GATA4, MARVELD3, MAP3K1, MAPK8, MAPK10, MAPK9, JUN, CD1A, CD1B, CD1C, CD1D, CD1E, CFTR, CDK4, YBX3, SYMPK, PCNA, CCND1, ERBB2, RUNX1, HSPA4, NHERF1, EZR, RDX, MSN, PRKCE, ACTG1, ACTB, CACNA1D, MAP3K5, MAP2K7, SRC, CTTN, HCLS1, ACTR2, ACTR3B, ACTR3C, ACTR3, ARPC1B, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, WHAMM, WAS, VASP, PRKACA, PRKACB, PRKACG, RAB13, ARHGEF18, ROCK1, ROCK2, MYL2, EPB41L4B, STK11, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, MYH9, MYH10, MYH11, MYH14, MYL6B, MYL6, MYL9, MYL12B, MYL12A, IGSF5, MAGI1, SYNPO, ACTN1, ACTN4, MICALL2, RAB8A, RAB8B, RAPGEF6, RAP1A, ITGB1, AFDN, TJP2, RAPGEF2, RAP2C, MARVELD2, TUBA1B, TUBA4A, TUBA3C, TUBA1A, TUBA1C, TUBA8, TUBA3E, TUBA3D, TUBAL3
## 125                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           CHRD, NOG, NBL1, MICOS10-NBL1, GREM1, GREM2, THBS1, DCN, FMOD, LEFTY1, LEFTY2, FST, BMP2, BMP4, BMP6, INHBB, BMP5, BMP7, BMP8B, BMP8A, GDF5, GDF6, GDF7, AMH, THSD4, FBN1, LTBP1, TGFB1, TGFB2, TGFB3, INHBA, INHBC, INHBE, NODAL, NEO1, HJV, BMPR1A, BMPR1B, ACVR1, BMPR2, ACVR2A, RGMA, RGMB, AMHR2, TGFBR1, TGFBR2, ACVR1B, ACVR2B, ACVR1C, IGSF1, BAMBI, SMAD1, SMAD5, SMAD9, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMURF1, SMURF2, ZFYVE9, ZFYVE16, HAMP, ID1, ID2, ID3, ID4, RBL1, E2F4, E2F5, TFDP1, CREBBP, EP300, SP1, TGIF1, TGIF2, MYC, CDKN2B, PITX2, RBX1, CUL1, SKP1, MAPK1, MAPK3, IFNG, TNF, RHOA, ROCK1, PPP2R1B, PPP2R1A, PPP2CA, PPP2CB, RPS6KB1, RPS6KB2
## 126                                                                                                                                                                                                                                                                                                                                            ARF6, PIP5K1C, PIP5K1A, PIP5K1B, PIP5KL1, PLD1, PLD2, DNM1, DNM3, DNM2, CLTA, CLTB, CLTC, CLTCL1, AP2A2, AP2A1, AP2B1, AP2M1, AP2S1, EHD2, TGFBR1, TGFBR2, ZFYVE9, ZFYVE16, PML, SMAD2, SMAD3, TFRC, EGFR, PDGFRA, FGFR2, FGFR3, FGFR4, IGF1R, CBL, CBLB, CBLC, SH3KBP1, SH3GL3, SH3GL2, SH3GL1, SH3GLB1, SH3GLB2, AMPH, BIN1, EPN1, EPN3, EPN2, EPS15, EPS15L1, SPART, NEDD4, NEDD4L, MDM2, TRAF6, RNF41, ITCH, SMURF1, SMURF2, WWP1, LDLR, LDLRAP1, DAB2, CCR5, CXCR1, CXCR2, CXCR4, GRK7, GRK1, GRK2, GRK3, GRK4, GRK5, GRK6, ARRB1, ARRB2, WASL, ACTR2, ACTR3B, ACTR3C, ACTR3, ARPC1B, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, WIPF2, WIPF1, WIPF3, HSPA8, HSPA1A, HSPA2, HSPA1L, HSPA1B, HSPA6, DNAJC6, WASHC4, WASHC5, WASHC2C, WASHC2A, WASHC1, WASHC3, CAPZA1, CAPZA2, CAPZA3, CAPZB, VPS29, VPS26B, VPS26A, VPS35, SNX12, SNX3, USP8, STAMBP, RAB7A, HGS, STAM2, STAM, TSG101, MVB12A, MVB12B, VPS28, VPS37D, VPS37A, VPS37B, VPS37C, SNF8, VPS36, VPS25, CHMP6, CHMP4B, CHMP4A, CHMP4C, CHMP3, RNF103-CHMP3, CHMP2A, CHMP2B, CHMP7, VPS4B, VPS4A, VTA1, CHMP1B, CHMP1A, CHMP5, IST1, PDCD6IP, SPG21, IGF2R, SNX1, SNX2, SNX32, SNX5, SNX6, SRC, HRAS, IL2RA, IL2RB, IL2RG, RHOA, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G, HLA-E, FOLR1, FOLR2, FOLR3, CAV1, CAV2, CAV3, EHD3, EHD4, EEA1, RAB5A, RAB5B, RAB5C, RABEP1, RBSN, RAB4A, RUFY1, RUFY2, EHD1, VPS45, SNX4, RAB22A, RAB31, RAB10, RAB8A, RAB35, RAB11A, RAB11B, RAB11FIP2, RAB11FIP1, RAB11FIP5, ZFYVE27, KIF5A, KIF5B, KIF5C, RAB11FIP4, RAB11FIP3, PARD3, PARD6A, PARD6G, PARD6B, PRKCZ, PRKCI, CDC42, SMAP2, SMAP1, GIT1, GIT2, ASAP1, ASAP3, ASAP2, ACAP3, ACAP2, ACAP1, ARAP1, ARAP2, ARAP3, AGAP1, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, AGAP2, ARFGAP1, ARFGAP3, ARFGAP2, PSD3, PSD4, PSD, PSD2, IQSEC2, IQSEC1, IQSEC3, CYTH3, CYTH4, CYTH2, CYTH1, ARFGEF2, ARFGEF1, GBF1, ARF1, ARF3, ARF4, ARF5
## 136                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     CACNA1C, CACNA1D, CACNA1F, CACNA1S, CACNB1, CACNB2, CACNB3, CACNB4, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, RYR2, ASPH, CASQ2, TRDN, HRC, ATP2A1, ATP2A3, ATP2A2, TNNC1, TNNI3, TNNT2, TPM1, TPM2, TPM3, TPM4, ACTC1, MYH7, MYH6, MYL2, MYL3, MYL4, UQCRFS1, CYTB, CYC1, UQCRC1, UQCRC2, UQCRH, UQCRHL, UQCRB, UQCRQ, UQCR10, UQCR11, COX3, COX1, COX2, COX4I2, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8C, COX8A, SLC8A1, SLC8A2, SLC8A3, SLC9A6, SLC9A7, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, FXYD2, SLC9A1
## 137                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   NTNG1, NTNG2, LRRC4C, LRRC4, NTN1, NTN3, NTN4, DCC, PLCG1, PLCG2, TRPC1, TRPC3, TRPC4, TRPC5, TRPC6, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, NFATC2, NFATC3, NFATC4, PTK2, FYN, SRC, RAC1, RAC2, RAC3, CDC42, ABLIM1, ABLIM3, ABLIM2, NCK1, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, BUB1B-PAK6, RHOA, ROCK1, ROCK2, UNC5A, UNC5B, UNC5C, UNC5D, PTPN11, RGMA, NEO1, MYL5, MYL9, MYL12B, MYL12A, ARHGEF12, LRIG2, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, ABL1, ENAH, RASA1, NGEF, HRAS, KRAS, NRAS, MAPK1, MAPK3, NCK2, RGS3, CXCL12, CXCR4, GNAI1, GNAI3, GNAI2, SLIT1, SLIT2, SLIT3, ROBO1, ROBO2, ROBO3, SRGAP2, SRGAP1, SRGAP3, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, PLXNA2, PLXNA3, PLXNA1, PLXNA4, NRP1, L1CAM, LIMK1, LIMK2, CFL1, CFL2, RHOD, RND1, FES, DPYSL5, DPYSL2, CDK5, GSK3B, SEMA4F, SEMA4D, SEMA4B, SEMA4C, SEMA4G, SEMA4A, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, PLXNB1, PLXNB2, PLXNB3, MET, RAF1, RRAS, SEMA7A, PLXNC1, ITGB1, SHH, PTCH1, SMO, PRKCA, ILK, BOC, WNT5A, WNT5B, FZD3, RYK, CAMK2A, CAMK2D, CAMK2B, CAMK2G, WNT4, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, PDPK1, PARD3, PRKCZ, PARD6A, PARD6G, PARD6B, SSH1, SSH3, SSH2, BMP7, GDF7, BMPR2, BMPR1B
## 138                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              TLR2, TLR4, TLR5, NFKB1, RELA, NOD2, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IFNG, IFNGR1, IFNGR2, STAT1, TBX21, IL4, IL5, IL12A, IL12B, IL12RB2, IL12RB1, STAT4, IL2, IL18, IL18R1, IL18RAP, JUN, TNF, IL6, IL1A, IL1B, TGFB1, TGFB2, TGFB3, SMAD2, SMAD3, STAT3, IL21, IL21R, IL23A, IL23R, RORC, RORA, FOXP3, IL17A, IL17F, IL22, IL4R, IL2RG, STAT6, GATA3, IL10, IL13, MAF, NFATC1
## 143                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                RORA, RORB, RORC, NR1D1, NR1D2, NFIL3, BMAL1, DBP, BHLHE40, BHLHE41, CSNK1D, CSNK1E, TPTEP2-CSNK1E, PER1, PER2, PER3, CRY1, CRY2, CLOCK, NPAS2, CREB1, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, RBX1, CUL1, SKP1, BTRC, FBXW11, FBXL3
## 156                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGA10, ITGA11, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, SGCD, SGCG, SGCA, SGCB, LAMA1, LAMA2, DAG1, DES, DMD, ACTG1, ACTB, TTN, TNNT2, TNNC1, TNNI3, ACTC1, TPM1, TPM2, TPM3, TPM4, MYBPC3, MYL3, MYL2, MYH7, MYH6, EMD, LMNA, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CACNB1, CACNB2, CACNB3, CACNB4, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, RYR2, ATP2A1, ATP2A3, ATP2A2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG3, PRKAG2, ACE, IGF1, TGFB1, TGFB2, TGFB3, TNF, IL6, EDN1, AGT, SLC8A1, SLC8A2, SLC8A3
## 144                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      PTPN11, MET, PLCG1, PLCG2, TJP1, F11R, JAM2, JAM3, IGSF5, ADAM17, HBEGF, EGFR, CXCL8, CXCR1, CXCR2, ADAM10, SRC, LYN, CSK, RAC1, CDC42, MAPK11, MAPK12, MAPK13, MAPK14, PAK1, MAP2K4, MAPK8, MAPK10, MAPK9, JUN, MAP3K14, CHUK, IKBKB, IKBKG, NFKBIA, NFKB1, RELA, NOD1, CXCL1, CXCL2, CXCL3, CCL5, PTPRZ1, GIT1, CASP3, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C2, ATP6V1C1, ATP6V1D, ATP6V1E2, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G3, ATP6V1G2, ATP6V0E1, ATP6V0E2, TCIRG1, ATP6V0A2, ATP6V0A4, ATP6V0A1, ATP6V0D1, ATP6V0D2, ATP6V1H, ATP6AP1, ATP6V0C, ATP6V0B
## 152                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C2, ATP6V1C1, ATP6V1D, ATP6V1E2, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G3, ATP6V1G2, ATP6V0E1, ATP6V0E2, TCIRG1, ATP6V0A2, ATP6V0A4, ATP6V0A1, ATP6V0D1, ATP6V0D2, ATP6V1H, ATP6AP1, ATP6V0C, ATP6V0B, KDELR1, KDELR2, KDELR3, PDIA4, ERO1A, SEC61A1, SEC61A2, SEC61B, SEC61G, ARF1, GNAS, ADCY3, ADCY9, PRKACA, PRKACB, PRKACG, CFTR, KCNQ1, SLC12A2, ACTG1, ACTB, PLCG1, PLCG2, PRKCA, TJP1, TJP2
## 148                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       PORCN, WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, CER1, NOTUM, WIF1, SOST, DKK1, DKK2, DKK4, SERPINF1, SFRP1, SFRP2, FRZB, SFRP4, SFRP5, RSPO1, RSPO2, RSPO3, RSPO4, LGR4, LGR5, LGR6, RNF43, ZNRF3, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, LRP5, LRP6, BAMBI, APCDD1, APCDD1L, CSNK1E, TPTEP2-CSNK1E, CCDC88C, DVL3, DVL2, DVL1, FRAT1, FRAT2, CSNK2A1, CSNK2A2, CSNK2A3, CSNK2B, NKD1, NKD2, CXXC4, SENP2, GSK3B, CTNNB1, AXIN1, AXIN2, APC, APC2, CSNK1A1L, CSNK1A1, TCF7, TCF7L1, TCF7L2, LEF1, CTNNBIP1, CBY1, CHD8, SOX17, CTBP1, CTBP2, TLE7, TLE1, TLE2, TLE3, TLE4, TLE6, CTNND2, CREBBP, EP300, RUVBL1, SMAD4, SMAD3, MAP3K7, NLK, MYC, JUN, FOSL1, CCND1, CCND2, CCND3, CCN4, PPARD, MMP7, PSEN1, PRKACA, PRKACB, PRKACG, TP53, SIAH1, CACYBP, SKP1, TBL1X, TBL1Y, TBL1XR1, BTRC, FBXW11, CUL1, RBX1, GPC4, ROR1, ROR2, RYK, VANGL2, VANGL1, PRICKLE1, PRICKLE2, PRICKLE4, PRICKLE3, INVS, DAAM1, DAAM2, RHOA, ROCK2, RAC1, RAC2, RAC3, MAPK8, MAPK10, MAPK9, PLCB1, PLCB2, PLCB3, PLCB4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB, PRKCG, NFATC1, NFATC2, NFATC3, NFATC4
## 162                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             CRB2, CRB1, PARD3, PARD6A, PARD6G, PARD6B, PRKCZ, PRKCI, PATJ, PALS1, AMOT, YAP1, WWTR1, CDH1, LIMD1, AJUBA, WTIP, NF2, WWC1, FRMD1, FRMD6, SAV1, STK3, RASSF6, RASSF1, PPP2CA, PPP2CB, PPP2R1B, PPP2R1A, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, LATS2, LATS1, MOB1A, MOB1B, PPP1CA, PPP1CB, PPP1CC, TP53BP2, LLGL2, LLGL1, SCRIB, DLG1, DLG2, DLG3, DLG4, DLG5, CSNK1D, CSNK1E, TPTEP2-CSNK1E, BTRC, FBXW11, TP73, BBC3, TEAD1, TEAD4, TEAD3, TEAD2, CCN2, GLI2, AREG, BIRC5, AFP, ITGB2, FGF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD7, SMAD2, SMAD3, SMAD4, SERPINE1, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8B, BMP8A, GDF5, GDF6, GDF7, AMH, BMPR1A, BMPR1B, BMPR2, SMAD1, ID1, ID2, WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, DVL3, DVL2, DVL1, YWHAZ, YWHAB, YWHAQ, YWHAE, YWHAH, YWHAG, GSK3B, CTNNB1, APC, APC2, AXIN1, AXIN2, NKD1, NKD2, TCF7, TCF7L1, TCF7L2, LEF1, MYC, CCND1, CCND2, CCND3, SOX2, SNAI2, BIRC2, BIRC3, ACTG1, ACTB, CTNNA3, CTNNA1, CTNNA2
## 153                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 VIP, CRH, CGA, LHB, GPHA2, GPHB5, TSHB, POMC, GCG, GIP, FSHB, NPPA, ADCYAP1, ADRB1, ADRB2, DRD1, DRD5, ADORA2A, HTR4, HTR6, PTGER2, ADCYAP1R1, VIPR2, CRHR1, CRHR2, LHCGR, TSHR, MC2R, GLP1R, GIPR, GPR119, FSHR, NPR1, GNAS, EDN1, EDN2, EDN3, SST, NPY, GHRL, OXT, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, CHRM1, CHRM2, DRD2, GABBR1, GABBR2, ADORA1, EDNRA, NPY1R, SSTR1, SSTR2, SSTR5, HCAR1, HCAR2, HCAR3, FFAR2, SUCNR1, PTGER3, OXTR, GHSR, GNAI1, GNAI3, GNAI2, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADCY10, HCN2, HCN4, CNGA1, CNGA2, CNGA3, CNGA4, CNGB1, CNGB3, CALML3, CALM2, CALM3, CALM1, CALML6, CALML5, CALML4, CAMK2A, CAMK2D, CAMK2B, CAMK2G, CAMK4, ABCC4, RAPGEF3, RAPGEF4, RRAS, RRAS2, PLD1, PLD2, PLCE1, MAPK8, MAPK10, MAPK9, RAP1A, RAP1B, TIAM1, VAV3, VAV1, VAV2, RAC1, RAC2, RAC3, PAK1, ARAP3, RHOA, AFDN, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, PRKACA, PRKACB, PRKACG, PPP1R1B, PPP1CA, PPP1CB, PPP1CC, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, CREBBP, EP300, BDNF, FOS, JUN, GLI3, GLI1, PTCH1, HHIP, NFKBIA, NFKB1, RELA, SOX9, AMH, PPARA, ACOX3, ACOX1, NFATC1, F2R, BAD, LIPE, ROCK1, ROCK2, PPP1R12A, MYL9, TNNI3, PLN, ATP2A1, ATP2A3, ATP2A2, RYR2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRIA1, GRIA2, GRIA3, GRIA4, CFTR, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B4, ATP1B1, ATP1B2, ATP1B3, FXYD2, FXYD1, SLC9A1, ORAI1, ATP2B1, ATP2B3, ATP2B4, ATP2B2, CACNA1C, CACNA1D, CACNA1F, CACNA1S, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE10A
## 158                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     JAM3, ITGAM, ITGB2, JAM2, ITGA4, ITGB1, PECAM1, CD99, CD99L2, ITGAL, F11R, CDH5, CLDN4, CLDN3, CLDN7, CLDN19, CLDN16, CLDN14, CLDN15, CLDN17, CLDN20, CLDN11, CLDN18, CLDN22, CLDN5, CLDN10, CLDN8, CLDN6, CLDN2, CLDN1, CLDN9, CLDN23, CLDN34, CLDN25, CLDN24, OCLN, ESAM, VCAM1, EZR, MSN, ACTG1, ACTB, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, RAC1, CYBB, CYBA, NCF2, NCF1, NCF4, CTNNB1, CTNND1, CTNNA3, CTNNA1, CTNNA2, PTPN11, MMP2, MMP9, MAPK11, MAPK12, MAPK13, MAPK14, ICAM1, PLCG1, PLCG2, PRKCA, PRKCB, PRKCG, PTK2, PXN, BCAR1, THY1, ARHGAP35, ARHGAP5, RHOA, ROCK1, ROCK2, MYL2, MYL5, MYL7, MYL9, MYL10, MYL12B, MYL12A, MYL11, AFDN, RAP1A, RAP1B, SIPA1, VASP, ACTN1, ACTN4, VCL, CXCL12, CXCR4, GNAI1, GNAI3, GNAI2, RAPGEF3, RAPGEF4, RASSF5, PTK2B, ITK, TXK, VAV3, VAV1, VAV2, RAC2, CDC42, RHOH
## 161                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       TSHB, CGA, TSHR, ADRB1, ADRB2, ADRB3, GNAS, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, PRKACA, PRKACB, PRKACG, NPPA, NPR1, PRKG1, PRKG2, PLIN1, CIDEC, LIPE, PNPLA2, ABHD5, MGLL, FABP4, AQP7, AQP7B, INS, INSR, IRS1, IRS2, IRS4, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3, PDE3B, PLAAT3, PLAAT2, PTGS1, PTGS2, ADORA1, PTGER3, NPY, NPY1R, GNAI1, GNAI3, GNAI2
## 164                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 MRPS2, MRPS5, MRPS6, MRPS7, MRPS9, MRPS10, MRPS11, MRPS12, MRPS14, MRPS15, MRPS16, MRPS17, MRPS18C, MRPS18A, MRPS21, RPS2, RPS3, RPS3A, RPS4Y1, RPS4X, RPS4Y2, RPS5, RPS6, RPS7, RPS8, RPS9, RPS10, RPS10-NUDT3, RPS11, RPS12, RPS13, RPS14, RPS15, RPS15A, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS27, RPS27L, RPS27A, RPS28, RPS29, FAU, RPSA, MRPL1, MRPL2, MRPL3, MRPL4, MRPL12, MRPL9, MRPL10, MRPL11, MRPL13, MRPL14, MRPL15, MRPL16, MRPL17, MRPL18, MRPL19, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL30, MRPL32, MRPL33, MRPL34, MRPL35, MRPL36, RPL3L, RPL3, RPL4, RPL5, RPL6, RPL7, RPL7A, RPL8, RPL9, RPL10L, RPL10, RPL10A, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL15, RPL17, RPL17-C18orf32, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL22, RPL23, RPL23A, RSL24D1, RPL24, RPL26, RPL26L1, RPL27, RPL27A, RPL28, RPL29, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36, RPL37, RPL37A, RPL38, RPL39, UBA52, RPL41, RPL36AL, RPL36A, RPL36A-HNRNPH2, RPLP0, RPLP1, RPLP2, RNA18SN1, RNA18SN4, RNA18SN5, RNA18SN2, RNA18SN3, RNA28SN5, RNA28SN2, RNA28SN4, RNA28SN3, RNA28SN1, RNA5S1, RNA5S16, RNA5S6, RNA5S11, RNA5S5, RNA5S13, RNA5S4, RNA5S3, RNA5S2, RNA5S10, RNA5S12, RNA5S8, RNA5S7, RNA5S14, RNA5S15, RNA5S17, RNA5S9, RNA5-8SN5, RNA5-8SN1, RNA5-8SN2, RNA5-8SN3, RNA5-8SN4
## 165                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            SCNN1A, SCNN1B, SCNN1G, ENTPD2, TAS1R2, TAS1R3, GNAT3, GNB3, GNG13, ADCY4, ADCY6, ADCY8, PRKACA, PRKACB, PRKACG, PLCB1, PLCB2, PLCB3, PLCB4, ITPR3, TRPM5, SCN2A, SCN3A, SCN9A, CALHM1, P2RX2, P2RX3, P2RY1, P2RY4, CHRM3, TAS1R1, GRM1, GRM4, TAS2R39, TAS2R40, TAS2R41, TAS2R43, TAS2R31, TAS2R45, TAS2R46, TAS2R19, TAS2R20, TAS2R50, TAS2R60, TAS2R42, TAS2R3, TAS2R4, TAS2R16, TAS2R1, TAS2R9, TAS2R8, TAS2R7, TAS2R13, TAS2R10, TAS2R14, TAS2R5, TAS2R38, TAS2R30, PDE1A, PDE1B, PDE1C, PKD2L1, PKD1L3, KCNK5, HCN4, CACNA1A, CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABBR1, GABBR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR3A, HTR3E, HTR3D, HTR3C, HTR3B, ASIC2
## 167                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    KITLG, IL7, IL4, CSF2, FLT3LG, IL5, CSF3, IL3, IL6, IL11, IL1A, IL1B, TNF, CSF1, EPO, THPO, CD34, FLT3, DNTT, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, CD44, KIT, IL2RA, IL7R, TFRC, CD38, CD7, CD2, CD5, CD1A, CD1B, CD1C, CD1D, CD1E, CD4, CD8A, CD8B, CD8B2, CD3D, CD3E, CD3G, MME, CD9, CD19, CD22, CD24, MS4A1, CR2, CD37, IGH, FCER2, CR1, CR1L, CSF2RA, IL3RA, CD33, IL4R, IL6R, FCGR1A, CSF1R, ANPEP, ITGAM, CD14, IL9R, IL1R1, IL1R2, CSF3R, IL5RA, EPOR, CD36, GYPA, CD55, CD59, IL11RA, ITGB3, ITGA2B, GP9, GP1BA, GP1BB, GP5, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6
## 168                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          RUNX1, CSF1R, MPO, CSF2, IL3, RUNX1T1, HDAC1, HDAC2, SIN3A, NCOR1, CEBPA, PER2, SPI1, CD14, ITGAM, FCGR1A, JUP, PML, RARA, CCNA2, CCNA1, CEBPE, BCL2A1, ZBTB16, MYC, DUSP6, TCF3, PBX1, WNT16, ETV6, ETV7, DEFA1, DEFA3, DEFA4, DEFA5, DEFA6, DEFA1B, ELANE, GZMB, KMT2A, AFF1, CDK9, CCNT1, CCNT2, MLLT1, MLLT3, DOT1L, LMO2, PBX3, RUNX2, SMAD1, KLF3, MEF2C, HOXA9, HOXA10, JMJD1C, HMGA2, KDM6A, SUPT3H, PROM1, FLT3, BMP2K, IGF1R, CDKN1B, CDK14, MEIS1, HOXA11, SIX1, SIX4, EYA1, CDKN2C, HPGD, GRIA3, FUT8, TLX3, TLX1, BCL11B, LDB1, LYL1, HHEX, PTCRA, REL, CCND2, BIRC2, BIRC3, TRAF1, BCL2L1, CD86, CD40, BCL6, IGH, MAF, ITGB7, NSD2, H3-5, H3-3B, H3C4, H3C3, H3C1, H3-3A, H3-4, H3C14, H3C15, H3C13, H3C6, H3C11, H3C8, H3C12, H3C10, H3C2, H3C7, PAX5, PAX8, PPARG, RXRA, RXRB, RXRG, PRCC, TFE3, CDKN1A, TMPRSS2, ERG, PLAU, PLAT, MMP3, MMP9, ZEB1, IL1R2, SPINT1, ETV1, ETV4, ETV5, SLC45A3, ELK4, DDX5, MYCN, MAX, MDM2, PTK2, TP53, BMI1, COMMD3-BMI1, SP1, ZBTB17, NTRK1, NGFR, MEN1, EWSR1, FLI1, IGF1, ID2, TGFBR2, IGFBP3, FEV, ATF1, ARNT2, ATM, MITF, WT1, PDGFA, IL2RB, BAIAP3, TSPAN7, MLF1, NR4A3, TAF15, FUS, DDIT3, CEBPB, IL6, NFKBIZ, NFKB1, RELA, CXCL8, PAX7, PAX3, FOXO1, FLT1, SS18L1, SS18, SSX1, SSX2, SSX2B, NUPR1, ASPSCR1, MET, GADD45A, GADD45B, GADD45G, BAX, BAK1, DDB2, POLK
##     num_genes_in_path num_up_reg_genes_in_path num_down_reg_genes_in_path
## 1                 266                       51                         25
## 2                 273                       50                         27
## 8                 155                       30                         19
## 9                 148                       14                         15
## 12                232                       34                         25
## 14                134                       24                         15
## 18                203                       21                         25
## 21                223                       28                         26
## 3                 131                       24                         12
## 4                  46                       19                          2
## 15                143                       26                         10
## 5                 127                       43                         11
## 7                 131                       23                          9
## 11                102                       18                         10
## 24                142                       19                          7
## 6                  73                       17                          7
## 10                 73                       13                         10
## 13                 97                        9                         13
## 16                128                       13                         11
## 23                 58                        7                          8
## 17                166                       10                         17
## 19                236                       20                         26
## 39                294                       27                         22
## 58                210                       15                         22
## 20                 89                       10                         12
## 25                108                       12                         11
## 27                121                       21                         13
## 29                107                       11                         14
## 46                137                       15                         17
## 47                 62                        7                          4
## 61                142                       17                         17
## 71                 69                       11                          6
## 22                222                       32                         24
## 65                203                       17                         19
## 26                 75                        7                          4
## 147                43                        7                          4
## 28                249                       35                         26
## 49                247                       21                         31
## 57                137                       16                         20
## 74                197                       18                         18
## 30                112                       12                         19
## 31                212                       19                         26
## 37                225                       11                         28
## 45                127                       11                         14
## 52                215                       17                         22
## 73                194                       12                         21
## 85                136                       16                         13
## 32                104                        8                         17
## 33                132                       10                         12
## 55                129                        4                         15
## 56                 75                        4                          9
## 60                150                        9                         13
## 64                120                        7                         14
## 68                 86                        3                          9
## 76                113                        6                         10
## 82                 98                        3                          8
## 95                106                        7                          9
## 101               137                        4                         12
## 111                65                        2                          9
## 121                64                        4                          7
## 133               167                        8                         18
## 34                157                       17                         15
## 40                162                       19                         18
## 42                139                       14                         18
## 43                202                       26                         25
## 53                 92                       18                          9
## 135               171                        9                         17
## 35                102                        8                         12
## 50                112                       10                         10
## 70                104                        6                         13
## 83                180                       13                         14
## 86                232                       10                         16
## 99                 77                        5                          5
## 112                76                        6                          6
## 130               104                        8                         12
## 36                121                        8                         16
## 160               189                        9                         13
## 38                119                        6                         15
## 63                 93                        5                          9
## 98                 98                        4                         12
## 41                 70                        9                          8
## 48                184                        9                         19
## 54                 94                        8                         14
## 44                 36                        4                          4
## 51                119                       14                         19
## 59                139                       14                         11
## 127               154                       11                          7
## 62                 97                       11                          7
## 75                 68                        4                         10
## 79                 76                       10                          8
## 81                 70                        7                          8
## 89                 72                        5                          7
## 100                85                        5                         10
## 102                59                        4                          8
## 106                67                        6                          8
## 108                72                        7                          5
## 113                76                        7                          8
## 115                75                        5                          7
## 119                86                        7                          5
## 128                98                        5                          9
## 131                58                        4                          3
## 134                81                        5                         10
## 140                69                        5                          4
## 146                97                        6                         12
## 166               131                        5                          9
## 66                192                        7                         27
## 67                100                       10                         12
## 69                229                       19                         21
## 155               201                       15                         15
## 72                205                       16                         20
## 91                101                        5                          9
## 107               143                       11                         14
## 109               147                       16                         17
## 110               149                       15                         11
## 120               155                       16                         16
## 150               155                       20                         17
## 154               168                       21                         16
## 77                141                       24                         17
## 78                212                       13                         24
## 80                 70                        4                          8
## 142               109                        7                         10
## 163                47                        3                          5
## 84                 72                        9                         15
## 87                156                       22                         16
## 88                 89                        4                         14
## 96                 92                        3                         16
## 103               104                        7                         15
## 132               108                        3                         12
## 90                124                        9                         19
## 92                 49                        3                          4
## 116                69                        3                          5
## 145               186                        9                         12
## 93                 69                        2                         11
## 97                 97                        2                          9
## 122               114                        1                          6
## 124                67                        2                          7
## 129                92                        1                          9
## 139                88                        5                          7
## 141                60                        2                          5
## 149               113                        4                          8
## 151                76                        1                          5
## 157               134                        4                         10
## 94                240                       16                         19
## 104               139                       16                         16
## 105                41                        3                          4
## 159                37                        4                          1
## 114               159                       11                         15
## 117                32                        5                          3
## 118               148                        8                         11
## 123               169                       18                         14
## 125                95                       13                          7
## 126               251                       19                         12
## 136                87                        7                          5
## 137               182                       14                         13
## 138                65                        1                          7
## 143                34                       10                          1
## 156                90                        7                          5
## 144                70                        5                          6
## 152                50                        3                          2
## 148               170                       14                         19
## 162               157                       17                         13
## 153               221                       10                         13
## 158               114                        2                         11
## 161                58                        2                          7
## 164               166                        1                          2
## 165                86                        2                          5
## 167                99                        6                          9
## 168               193                       13                          7
##     percent_up_or_down_genes_pathway Cluster         Status
## 1                         0.28571429       1 Representative
## 2                         0.28205128       1         Member
## 8                         0.31612903       1         Member
## 9                         0.19594595       1         Member
## 12                        0.25431034       1         Member
## 14                        0.29104478       1         Member
## 18                        0.22660099       1         Member
## 21                        0.24215247       1         Member
## 3                         0.27480916       2 Representative
## 4                         0.45652174       3 Representative
## 15                        0.25174825       3         Member
## 5                         0.42519685       4 Representative
## 7                         0.24427481       4         Member
## 11                        0.27450980       4         Member
## 24                        0.18309859       4         Member
## 6                         0.32876712       5 Representative
## 10                        0.31506849       6 Representative
## 13                        0.22680412       6         Member
## 16                        0.18750000       7 Representative
## 23                        0.25862069       7         Member
## 17                        0.16265060       8 Representative
## 19                        0.19491525       9 Representative
## 39                        0.16666667       9         Member
## 58                        0.17619048       9         Member
## 20                        0.24719101      10 Representative
## 25                        0.21296296      10         Member
## 27                        0.28099174      10         Member
## 29                        0.23364486      10         Member
## 46                        0.23357664      10         Member
## 47                        0.17741935      10         Member
## 61                        0.23943662      10         Member
## 71                        0.24637681      10         Member
## 22                        0.25225225      11 Representative
## 65                        0.17733990      11         Member
## 26                        0.14666667      12 Representative
## 147                       0.25581395      12         Member
## 28                        0.24497992      13 Representative
## 49                        0.21052632      13         Member
## 57                        0.26277372      13         Member
## 74                        0.18274112      13         Member
## 30                        0.27678571      14 Representative
## 31                        0.21226415      14         Member
## 37                        0.17333333      14         Member
## 45                        0.19685039      14         Member
## 52                        0.18139535      14         Member
## 73                        0.17010309      14         Member
## 85                        0.21323529      14         Member
## 32                        0.24038462      15 Representative
## 33                        0.16666667      16 Representative
## 55                        0.14728682      16         Member
## 56                        0.17333333      16         Member
## 60                        0.14666667      16         Member
## 64                        0.17500000      16         Member
## 68                        0.13953488      16         Member
## 76                        0.14159292      16         Member
## 82                        0.11224490      16         Member
## 95                        0.15094340      16         Member
## 101                       0.11678832      16         Member
## 111                       0.16923077      16         Member
## 121                       0.17187500      16         Member
## 133                       0.15568862      16         Member
## 34                        0.20382166      17 Representative
## 40                        0.22839506      17         Member
## 42                        0.23021583      17         Member
## 43                        0.25247525      17         Member
## 53                        0.29347826      17         Member
## 135                       0.15204678      17         Member
## 35                        0.19607843      18 Representative
## 50                        0.17857143      18         Member
## 70                        0.18269231      18         Member
## 83                        0.15000000      18         Member
## 86                        0.11206897      18         Member
## 99                        0.12987013      18         Member
## 112                       0.15789474      18         Member
## 130                       0.19230769      18         Member
## 36                        0.19834711      19 Representative
## 160                       0.11640212      19         Member
## 38                        0.17647059      20 Representative
## 63                        0.15053763      20         Member
## 98                        0.16326531      20         Member
## 41                        0.24285714      21 Representative
## 48                        0.15217391      21         Member
## 54                        0.23404255      21         Member
## 44                        0.22222222      22 Representative
## 51                        0.27731092      23 Representative
## 59                        0.17985612      24 Representative
## 127                       0.11688312      24         Member
## 62                        0.18556701      25 Representative
## 75                        0.20588235      25         Member
## 79                        0.23684211      25         Member
## 81                        0.21428571      25         Member
## 89                        0.16666667      25         Member
## 100                       0.17647059      25         Member
## 102                       0.20338983      25         Member
## 106                       0.20895522      25         Member
## 108                       0.16666667      25         Member
## 113                       0.19736842      25         Member
## 115                       0.16000000      25         Member
## 119                       0.13953488      25         Member
## 128                       0.14285714      25         Member
## 131                       0.12068966      25         Member
## 134                       0.18518519      25         Member
## 140                       0.13043478      25         Member
## 146                       0.18556701      25         Member
## 166                       0.10687023      25         Member
## 66                        0.17708333      26 Representative
## 67                        0.22000000      27 Representative
## 69                        0.17467249      28 Representative
## 155                       0.14925373      28         Member
## 72                        0.17560976      29 Representative
## 91                        0.13861386      29         Member
## 107                       0.17482517      29         Member
## 109                       0.22448980      29         Member
## 110                       0.17449664      29         Member
## 120                       0.20645161      29         Member
## 150                       0.23870968      29         Member
## 154                       0.22023810      29         Member
## 77                        0.29078014      30 Representative
## 78                        0.17452830      31 Representative
## 80                        0.17142857      32 Representative
## 142                       0.15596330      32         Member
## 163                       0.17021277      32         Member
## 84                        0.33333333      33 Representative
## 87                        0.24358974      34 Representative
## 88                        0.20224719      35 Representative
## 96                        0.20652174      35         Member
## 103                       0.21153846      35         Member
## 132                       0.13888889      35         Member
## 90                        0.22580645      36 Representative
## 92                        0.14285714      37 Representative
## 116                       0.11594203      37         Member
## 145                       0.11290323      37         Member
## 93                        0.18840580      38 Representative
## 97                        0.11340206      38         Member
## 122                       0.06140351      38         Member
## 124                       0.13432836      38         Member
## 129                       0.10869565      38         Member
## 139                       0.13636364      38         Member
## 141                       0.11666667      38         Member
## 149                       0.10619469      38         Member
## 151                       0.07894737      38         Member
## 157                       0.10447761      38         Member
## 94                        0.14583333      39 Representative
## 104                       0.23021583      40 Representative
## 105                       0.17073171      41 Representative
## 159                       0.13513514      41         Member
## 114                       0.16352201      42 Representative
## 117                       0.25000000      43 Representative
## 118                       0.12837838      44 Representative
## 123                       0.18934911      45 Representative
## 125                       0.21052632      46 Representative
## 126                       0.12350598      47 Representative
## 136                       0.13793103      48 Representative
## 137                       0.14835165      49 Representative
## 138                       0.12307692      50 Representative
## 143                       0.32352941      51 Representative
## 156                       0.13333333      51         Member
## 144                       0.15714286      52 Representative
## 152                       0.10000000      52         Member
## 148                       0.19411765      53 Representative
## 162                       0.19108280      53         Member
## 153                       0.10407240      54 Representative
## 158                       0.11403509      55 Representative
## 161                       0.15517241      56 Representative
## 164                       0.01807229      57 Representative
## 165                       0.08139535      58 Representative
## 167                       0.15151515      59 Representative
## 168                       0.10362694      60 Representative
dev.off()
## quartz_off_screen 
##                 2
output_pin_clustered <- cluster_enriched_terms(output_df_pin, plot_dend = TRUE, plot_clusters_graph = TRUE)
## The maximum average silhouette width was 0.14 for k = 60

selected_clusters <- subset(output_pin_clustered, Cluster %in% 1:5)


pdf(file = paste0(outdir,"/Enrichment_with_", pin, "_clusters_1-5.pdf"))

enrichment_chart(selected_clusters, plot_by_cluster = TRUE)
## Plotting the enrichment bubble chart
dev.off()
## quartz_off_screen 
##                 2
enrichment_chart(selected_clusters, plot_by_cluster = TRUE)
## Plotting the enrichment bubble chart

selected_clusters <- subset(output_pin_clustered, Cluster %in% 6:10)

pdf(file = paste0(outdir,"/Enrichment_with_", pin, "_clusters_6-10.pdf"))
enrichment_chart(selected_clusters, plot_by_cluster = TRUE)
## Plotting the enrichment bubble chart
dev.off()
## quartz_off_screen 
##                 2
enrichment_chart(selected_clusters, plot_by_cluster = TRUE)
## Plotting the enrichment bubble chart

Make heatmap of enriched pathways vs differentially expressed genes

pdf(file = paste0(outdir,"/Enrichment_heatmap_", pin, "_up_or_down_10_terms.pdf"))
term_gene_heatmap(result_df = output_df_pin, num_terms = 10)
dev.off()
## quartz_off_screen 
##                 2
#pdf(file = paste0(outdir,"/Enrichment_heatmap_", pin, "_fold_change_10_terms.pdf"))
#term_gene_heatmap(result_df = output_df_pin, genes_df = datPF, num_terms = 10)
#dev.off()

term_gene_heatmap(result_df = output_df_pin, num_terms = 10)

#term_gene_heatmap(result_df = output_df_pin, genes_df = datPF, num_terms = 10)

Term gene graph of top enriched terms.

pdf(file=paste0(outdir,"/Enrichment_Term-Gene_Graph_", pin, "_top_5_terms.pdf"), width=11, height=8.5)

term_gene_graph(result_df = output_df_pin, use_description = TRUE, num_terms = 5)
dev.off()
## quartz_off_screen 
##                 2
term_gene_graph(result_df = output_df_pin, use_description = TRUE, num_terms = 3)

pdf(file=paste0(outdir,"/Enrichment_Term-Gene_Graph_", pin, "_top_10_terms.pdf"), width=11, height=8.5)
term_gene_graph(result_df = output_df_pin, use_description = TRUE, num_terms = 10)
dev.off()
## quartz_off_screen 
##                 2
term_gene_graph(result_df = output_df_pin, use_description = TRUE, num_terms = 10)
## Warning: ggrepel: 43 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps

Make an UpSet heatmap of enriched pathways vs differentially expressed genes

pdf(file = paste0(outdir,"/Enrichment_UpSet_plot_", pin, "_up_or_down_10_terms.pdf"))
UpSet_plot(result_df = output_df_pin)
dev.off()
## quartz_off_screen 
##                 2
pdf(file = paste0(outdir,"/Enrichment_UpSet_plot_", pin, "_fold_change_10_terms.pdf"))
UpSet_plot(result_df = output_df_pin, genes_df = datPF, num_terms = 10)
## ## Processing input. Converting gene symbols,
##           if necessary (and if human gene symbols provided)
## Number of genes provided in input: 10881
## Number of genes in input after p-value filtering: 10881
## pathfindR cannot handle p values < 1e-13. These were changed to 1e-13
## Could not find any interactions for 7105 (65.3%) genes in the PIN
## Final number of genes in input: 3776
dev.off()
## quartz_off_screen 
##                 2
UpSet_plot(result_df = output_df_pin)

UpSet_plot(result_df = output_df_pin, genes_df = datPF, num_terms = 10)
## ## Processing input. Converting gene symbols,
##           if necessary (and if human gene symbols provided)
## Number of genes provided in input: 10881
## Number of genes in input after p-value filtering: 10881
## pathfindR cannot handle p values < 1e-13. These were changed to 1e-13
## Could not find any interactions for 7105 (65.3%) genes in the PIN
## Final number of genes in input: 3776

# make a score matrix of enriched pathways by sample.

“calculate the agglomerated z score of each enriched term per sample. This allows the user to individually examine the scores and infer how a term is overall altered (activated or repressed) in a given sample or a group of samples.”

representative_df <- output_pin_clustered[output_pin_clustered$Status == "Representative", ]

representative_df <- as.data.frame(representative_df)

dat.m <- as.matrix(dat)


pdf(file=paste0(outdir,"/Enrichment_Score_Matrix_rep_terms_", pin, "_by_sample.pdf"))
score_matrix <- score_terms(
  enrichment_table = representative_df,
  exp_mat = dat.m,
  cases = cases,
  use_description = TRUE, # default FALSE
  label_samples = TRUE, # default = TRUE
  #case_title = "R", # default = "Case"
  #control_title = "", # default = "Control",
  low = "#f7797d", # default = "green"
  mid = "#fffde4", # default = "black"
  high = "#1f4037" # default = "red"
)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
dev.off()
## quartz_off_screen 
##                 2
pdf(file=paste0(outdir,"/Enrichment_Score_Matrix_all_terms_", pin, "_by_sample.pdf"))
score_matrix <- score_terms(
  enrichment_table = output_pin_clustered,
  exp_mat = dat.m,
  cases=cases,
  use_description = TRUE, # default FALSE
  label_samples = TRUE, # default = TRUE
  #case_title = "RA", # default = "Case"
  #control_title = "Healthy", # default = "Control"
  low = "#f7797d", # default = "green"
  mid = "#fffde4", # default = "black"
  high = "#1f4037" # default = "red"
)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
dev.off()
## quartz_off_screen 
##                 2
score_matrix <- score_terms(
  enrichment_table = representative_df,
  exp_mat = dat.m,
  cases = cases,
  use_description = TRUE, # default FALSE
  label_samples = TRUE, # default = TRUE
  #case_title = "R", # default = "Case"
  #control_title = "", # default = "Control",
  low = "#f7797d", # default = "green"
  mid = "#fffde4", # default = "black"
  high = "#1f4037" # default = "red"
)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

score_matrix <- score_terms(
  enrichment_table = output_pin_clustered,
  exp_mat = dat.m,
  cases=cases,
  use_description = TRUE, # default FALSE
  label_samples = TRUE, # default = TRUE
  #case_title = "RA", # default = "Case"
  #control_title = "Healthy", # default = "Control"
  low = "#f7797d", # default = "green"
  mid = "#fffde4", # default = "black"
  high = "#1f4037" # default = "red"
)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(all_scores_matrix, current_term_scores): number of columns of
## result is not a multiple of vector length (arg 2)
## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

## Warning in rbind(current_term_score_matrix, gene_scores): number of columns of
## result is not a multiple of vector length (arg 2)

Save data!

write.csv(output_pin_clustered, file=paste0(outdir,"/PathfindR_output_", pin, ".csv"))